Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02632:Or51m1'

301347

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or51m1

Ensembl Gene

ENSMUSG00000042219

Gene Name

olfactory receptor family 51 subfamily M member 1

Synonyms

Olfr631, MOR3-1, GA_x6K02T2PBJ9-6662699-6663658

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

IGL02632

Quality Score

Status

Chromosome

Chromosomal Location

103578032-103578991 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 103578914 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 295 (I295V)

Ref Sequence

ENSEMBL: ENSMUSP00000102476 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106863] [ENSMUST00000214711]

AlphaFold

F8VPJ9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000106863
AA Change: I295V

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000102476
Gene: ENSMUSG00000042219
AA Change: I295V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	311	2e-114	PFAM
Pfam:7TM_GPCR_Srsx	36	308	6.6e-8	PFAM
Pfam:7tm_1	42	293	4.8e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214509

Predicted Effect

probably benign
Transcript: ENSMUST00000214711

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam25	T	C	8: 41,208,237 (GRCm39)	V501A	possibly damaging	Het
Alpl	T	G	4: 137,481,217 (GRCm39)	N145T	probably damaging	Het
Aqp5	T	A	15: 99,491,216 (GRCm39)		probably benign	Het
Atp1a2	T	A	1: 172,108,181 (GRCm39)	D640V	possibly damaging	Het
Atp5po	T	C	16: 91,725,830 (GRCm39)	E49G	probably benign	Het
Card14	A	G	11: 119,229,730 (GRCm39)	D747G	probably benign	Het
Cfap47	A	T	X: 78,540,279 (GRCm39)	L553H	probably damaging	Het
Cpz	A	T	5: 35,669,155 (GRCm39)	D325E	possibly damaging	Het
Crim1	T	C	17: 78,680,103 (GRCm39)	I948T	probably benign	Het
Dpysl3	A	T	18: 43,526,090 (GRCm39)	S2T	possibly damaging	Het
Fat4	T	C	3: 39,056,913 (GRCm39)	V4203A	probably benign	Het
Gapvd1	G	A	2: 34,574,186 (GRCm39)		probably benign	Het
Gpatch2	A	G	1: 186,958,178 (GRCm39)	R155G	probably damaging	Het
Grpr	A	T	X: 162,298,090 (GRCm39)	V318E	probably damaging	Het
Hipk1	T	C	3: 103,667,861 (GRCm39)	T569A	probably benign	Het
Il3ra	G	A	14: 14,350,807 (GRCm38)		probably null	Het
Llgl2	A	G	11: 115,735,698 (GRCm39)	H98R	probably damaging	Het
Loxhd1	A	G	18: 77,493,628 (GRCm39)	D663G	probably damaging	Het
Lrrc71	T	C	3: 87,650,647 (GRCm39)	N205S	probably damaging	Het
Mamdc2	C	T	19: 23,308,340 (GRCm39)	E521K	probably benign	Het
Mapre2	A	G	18: 23,991,217 (GRCm39)	M162V	probably benign	Het
Mettl22	T	C	16: 8,302,117 (GRCm39)		probably benign	Het
Mib2	T	C	4: 155,740,036 (GRCm39)	D739G	probably damaging	Het
Mroh2b	T	C	15: 4,960,583 (GRCm39)	F772S	probably damaging	Het
Mtss1	C	T	15: 58,815,864 (GRCm39)	M565I	probably damaging	Het
Myt1l	T	G	12: 29,964,292 (GRCm39)	S1077A	unknown	Het
Nalcn	T	C	14: 123,555,265 (GRCm39)	T873A	probably benign	Het
Nwd1	T	A	8: 73,394,082 (GRCm39)	H448Q	possibly damaging	Het
Odad2	A	G	18: 7,214,727 (GRCm39)		probably benign	Het
Or14j3	T	C	17: 37,901,232 (GRCm39)	E4G	probably benign	Het
Or5j3	T	C	2: 86,128,904 (GRCm39)	V248A	probably damaging	Het
Palld	C	T	8: 61,968,279 (GRCm39)	E1096K	probably damaging	Het
Pdcd2	A	G	17: 15,742,054 (GRCm39)	V292A	probably damaging	Het
Pde2a	A	G	7: 101,153,863 (GRCm39)	Y477C	probably damaging	Het
Pramel16	A	G	4: 143,676,507 (GRCm39)	I199T	possibly damaging	Het
Rcbtb1	T	C	14: 59,462,131 (GRCm39)	L254P	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Rsl1	A	C	13: 67,330,227 (GRCm39)	H225P	probably damaging	Het
Sec14l2	T	C	11: 4,061,222 (GRCm39)	I80V	probably benign	Het
Sema6a	G	T	18: 47,423,222 (GRCm39)	D261E	probably damaging	Het
Serpinb9b	T	A	13: 33,223,806 (GRCm39)	S333T	probably benign	Het
Slc24a4	T	C	12: 102,200,941 (GRCm39)	V277A	probably benign	Het
Snap91	T	A	9: 86,721,575 (GRCm39)	H88L	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tmprss15	T	A	16: 78,782,790 (GRCm39)	N758I	probably damaging	Het
Ube3b	C	T	5: 114,536,902 (GRCm39)	A300V	probably benign	Het
Vmn2r82	G	A	10: 79,192,542 (GRCm39)	V40I	probably benign	Het
Vsig4	G	T	X: 95,291,378 (GRCm39)	Q265K	probably benign	Het
Wdr91	T	C	6: 34,865,977 (GRCm39)	D525G	probably damaging	Het

Other mutations in Or51m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02732:Or51m1	APN	7	103,578,336 (GRCm39)	missense	probably damaging	1.00
IGL02834:Or51m1	APN	7	103,578,601 (GRCm39)	nonsense	probably null
IGL03089:Or51m1	APN	7	103,578,329 (GRCm39)	missense	probably benign	0.01
IGL03137:Or51m1	APN	7	103,578,801 (GRCm39)	missense	probably benign
IGL03407:Or51m1	APN	7	103,578,158 (GRCm39)	missense	probably damaging	1.00
R0034:Or51m1	UTSW	7	103,578,708 (GRCm39)	missense	probably benign	0.04
R1768:Or51m1	UTSW	7	103,578,932 (GRCm39)	nonsense	probably null
R1779:Or51m1	UTSW	7	103,578,668 (GRCm39)	missense	probably benign	0.39
R1933:Or51m1	UTSW	7	103,578,337 (GRCm39)	missense	probably damaging	0.99
R4976:Or51m1	UTSW	7	103,578,944 (GRCm39)	missense	probably benign
R5783:Or51m1	UTSW	7	103,578,149 (GRCm39)	missense	probably damaging	1.00
R5888:Or51m1	UTSW	7	103,578,239 (GRCm39)	missense	possibly damaging	0.47
R6051:Or51m1	UTSW	7	103,578,084 (GRCm39)	missense	probably damaging	0.98
R7016:Or51m1	UTSW	7	103,578,737 (GRCm39)	missense	probably benign	0.01
R7605:Or51m1	UTSW	7	103,578,075 (GRCm39)	missense	probably damaging	1.00
R8247:Or51m1	UTSW	7	103,578,783 (GRCm39)	missense	possibly damaging	0.46
R9420:Or51m1	UTSW	7	103,578,980 (GRCm39)	missense	possibly damaging	0.93
Z1176:Or51m1	UTSW	7	103,578,984 (GRCm39)	nonsense	probably null

Posted On

2015-04-16