Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02653:Ptgr3'

302250

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ptgr3

Ensembl Gene

ENSMUSG00000049090

Gene Name

prostaglandin reductase 3

Synonyms

C530046K17Rik, Pthr3, Zadh2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.189) question?

Stock #

IGL02653

Quality Score

Status

Chromosome

Chromosomal Location

84106250-84115579 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 84113443 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 373 (V373A)

Ref Sequence

ENSEMBL: ENSMUSP00000052544 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060223]

AlphaFold

Q8BGC4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060223
AA Change: V373A

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000052544
Gene: ENSMUSG00000049090
AA Change: V373A

Domain	Start	End	E-Value	Type
Pfam:ADH_N_2	42	183	1.5e-14	PFAM
Pfam:ADH_N	62	126	4e-8	PFAM
Pfam:ADH_zinc_N	184	321	9e-30	PFAM
Pfam:ADH_zinc_N_2	216	367	1.7e-16	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc8	T	C	7: 45,765,191 (GRCm39)		probably benign	Het
Alox5	T	A	6: 116,392,438 (GRCm39)	H361L	probably benign	Het
Arid2	A	G	15: 96,185,583 (GRCm39)	N3S	probably damaging	Het
Atp1a4	T	A	1: 172,078,973 (GRCm39)	I182F	possibly damaging	Het
Cby2	T	C	14: 75,820,597 (GRCm39)	D385G	probably damaging	Het
Ctnna2	A	T	6: 76,957,760 (GRCm39)	D496E	probably benign	Het
Cyp3a25	G	T	5: 145,939,920 (GRCm39)	S29Y	possibly damaging	Het
Dglucy	G	A	12: 100,837,690 (GRCm39)	G611D	probably benign	Het
Efcab5	T	C	11: 77,022,848 (GRCm39)	K622E	probably damaging	Het
Esyt1	T	A	10: 128,346,877 (GRCm39)	I1071L	probably benign	Het
Fbn2	T	C	18: 58,209,777 (GRCm39)	K1035E	probably benign	Het
Frem1	T	G	4: 82,877,571 (GRCm39)	E1335D	probably benign	Het
Gm5900	A	G	7: 104,599,340 (GRCm39)		noncoding transcript	Het
Ikbke	T	A	1: 131,199,572 (GRCm39)	Q283L	possibly damaging	Het
Lepr	A	T	4: 101,622,141 (GRCm39)	I358F	probably benign	Het
Lnpk	A	G	2: 74,378,392 (GRCm39)	V123A	probably damaging	Het
Mis12	A	G	11: 70,916,357 (GRCm39)	K130R	probably damaging	Het
Ncapg2	T	A	12: 116,389,526 (GRCm39)		probably null	Het
Npy6r	T	C	18: 44,409,694 (GRCm39)	*372Q	probably null	Het
Polr3d	T	C	14: 70,677,557 (GRCm39)	D273G	probably damaging	Het
Ppp2r3d	A	G	9: 101,088,892 (GRCm39)	V477A	probably benign	Het
Prpf19	T	A	19: 10,880,328 (GRCm39)		probably benign	Het
Pwwp2a	A	G	11: 43,596,862 (GRCm39)	T676A	possibly damaging	Het
Ralgapb	T	A	2: 158,285,229 (GRCm39)	I242N	probably damaging	Het
Scn3a	A	T	2: 65,291,531 (GRCm39)	S1738R	probably damaging	Het
Snapc1	C	A	12: 74,029,261 (GRCm39)	P348Q	probably benign	Het
Tbc1d7	T	C	13: 43,318,874 (GRCm39)	I88V	probably benign	Het
Tnks2	T	C	19: 36,849,851 (GRCm39)	S220P	probably damaging	Het
Trim56	A	T	5: 137,141,760 (GRCm39)	S585R	probably damaging	Het
Trpm2	T	G	10: 77,748,503 (GRCm39)	E1389A	probably benign	Het
Tspear	T	A	10: 77,542,799 (GRCm39)		probably benign	Het
Vmn1r180	T	C	7: 23,652,500 (GRCm39)	I221T	probably damaging	Het
Vmn1r204	A	C	13: 22,740,800 (GRCm39)	I144L	probably benign	Het
Vmn2r20	A	T	6: 123,362,324 (GRCm39)	I820N	probably damaging	Het
Vwa3b	T	A	1: 37,214,646 (GRCm39)		probably benign	Het
Wnt1	G	A	15: 98,690,336 (GRCm39)	G222R	probably damaging	Het

Other mutations in Ptgr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02063:Ptgr3	APN	18	84,113,390 (GRCm39)	nonsense	probably null
R0678:Ptgr3	UTSW	18	84,113,287 (GRCm39)	missense	probably benign
R0905:Ptgr3	UTSW	18	84,113,332 (GRCm39)	missense	probably benign	0.00
R1434:Ptgr3	UTSW	18	84,112,596 (GRCm39)	missense	probably benign	0.42
R1524:Ptgr3	UTSW	18	84,112,831 (GRCm39)	missense	probably benign
R1862:Ptgr3	UTSW	18	84,113,443 (GRCm39)	missense	possibly damaging	0.82
R2141:Ptgr3	UTSW	18	84,112,668 (GRCm39)	missense	probably benign	0.00
R4299:Ptgr3	UTSW	18	84,112,626 (GRCm39)	missense	possibly damaging	0.94
R5378:Ptgr3	UTSW	18	84,112,803 (GRCm39)	missense	probably damaging	1.00
R7322:Ptgr3	UTSW	18	84,113,260 (GRCm39)	missense	probably damaging	1.00
R7394:Ptgr3	UTSW	18	84,106,315 (GRCm39)	missense	probably benign	0.00
R8141:Ptgr3	UTSW	18	84,112,651 (GRCm39)	missense	probably benign	0.01
R9731:Ptgr3	UTSW	18	84,113,128 (GRCm39)	missense	probably damaging	1.00
Z1088:Ptgr3	UTSW	18	84,113,052 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16