Incidental Mutation 'IGL02721:Ifna1'
ID304990
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna1
Ensembl Gene ENSMUSG00000095498
Gene Nameinterferon alpha 1
SynonymsIfa1
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02721
Quality Score
Status
Chromosome4
Chromosomal Location88850087-88850656 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88850286 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 67 (D67G)
Ref Sequence ENSEMBL: ENSMUSP00000092580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094972]
Predicted Effect probably benign
Transcript: ENSMUST00000094972
AA Change: D67G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000092580
Gene: ENSMUSG00000095498
AA Change: D67G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.84e-76 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik T A 9: 55,980,840 I398L probably benign Het
4931414P19Rik A G 14: 54,585,745 S332P probably damaging Het
Abca7 T C 10: 80,013,635 S1877P possibly damaging Het
Adora2b G T 11: 62,265,105 A127S probably damaging Het
Ahnak A G 19: 9,009,707 K2785R probably benign Het
Anapc2 G A 2: 25,274,668 W21* probably null Het
Atp7b A G 8: 22,022,477 S457P probably benign Het
Catsperb A G 12: 101,625,297 Q1046R probably null Het
Comp A T 8: 70,376,081 N188Y probably damaging Het
Crnkl1 A T 2: 145,923,881 I423K possibly damaging Het
Crtap A T 9: 114,381,639 V289E probably damaging Het
Ctnna2 T C 6: 76,981,869 N454S probably damaging Het
Dnah5 A T 15: 28,234,243 probably null Het
Dstyk T G 1: 132,449,316 V220G probably benign Het
E230025N22Rik C T 18: 36,695,611 V5M probably damaging Het
Fam111a T G 19: 12,586,972 N28K probably benign Het
Fbxo32 A G 15: 58,182,962 I284T possibly damaging Het
Fgb A C 3: 83,043,367 V360G possibly damaging Het
Gm3404 A T 5: 146,526,928 R128* probably null Het
Gm5152 T C 5: 10,243,916 K106E probably damaging Het
Hal G T 10: 93,507,498 G535* probably null Het
Igsf5 T A 16: 96,391,022 S274T probably damaging Het
Kdm7a C T 6: 39,173,437 A134T possibly damaging Het
Klhl25 G T 7: 75,866,900 W518L probably damaging Het
Map1a A T 2: 121,304,037 D1778V probably benign Het
Nif3l1 A G 1: 58,457,849 D311G probably damaging Het
Numa1 A G 7: 101,999,911 T950A probably benign Het
Nup54 A T 5: 92,417,857 I406N possibly damaging Het
Olfr1389 T A 11: 49,430,641 L55* probably null Het
Olfr509 G T 7: 108,646,375 S67* probably null Het
Olfr800 C T 10: 129,659,955 P50S probably benign Het
Olfr801 A T 10: 129,670,123 I132N probably benign Het
Pcdhb18 T A 18: 37,490,031 M138K probably benign Het
Pik3c2g A G 6: 139,736,973 T27A probably benign Het
Plekhb2 A G 1: 34,869,364 N163S probably benign Het
Ros1 G A 10: 52,172,831 probably benign Het
Sh3gl1 A G 17: 56,017,577 L357P possibly damaging Het
Skint5 T A 4: 113,942,549 D141V probably damaging Het
Slc10a5 A G 3: 10,334,535 V355A probably benign Het
Ssh2 G T 11: 77,454,725 G1179* probably null Het
Syde2 A G 3: 146,002,004 N566S probably damaging Het
Sytl1 T C 4: 133,258,878 R149G probably benign Het
Tnpo2 A G 8: 85,054,690 probably null Het
Top2b T C 14: 16,409,236 L793P probably damaging Het
U2surp T A 9: 95,474,435 E789D probably benign Het
Vps13c G A 9: 67,964,149 probably benign Het
Zbtb34 C T 2: 33,411,258 G424R probably damaging Het
Zfhx4 A G 3: 5,243,307 D531G possibly damaging Het
Zfp787 C T 7: 6,132,464 probably null Het
Other mutations in Ifna1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02630:Ifna1 APN 4 88850259 missense possibly damaging 0.47
IGL02675:Ifna1 APN 4 88850433 missense probably damaging 1.00
IGL02680:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02681:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02709:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02710:Ifna1 APN 4 88850286 missense probably benign 0.01
IGL02712:Ifna1 APN 4 88850286 missense probably benign 0.01
R1630:Ifna1 UTSW 4 88850329 missense probably benign 0.00
R2897:Ifna1 UTSW 4 88850213 missense probably benign
R6150:Ifna1 UTSW 4 88850112 missense probably null 0.34
Posted On2015-04-16