Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02803:Gpr65'

360300

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr65

Ensembl Gene

ENSMUSG00000021886

Gene Name

G-protein coupled receptor 65

Synonyms

TDAG8, Gpcr25, Dig1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02803

Quality Score

Status

Chromosome

Chromosomal Location

98268635-98276644 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 98275210 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 41 (S41P)

Ref Sequence

ENSEMBL: ENSMUSP00000074581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075072]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000075072
AA Change: S41P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000074581
Gene: ENSMUSG00000021886
AA Change: S41P

Domain	Start	End	E-Value	Type
Pfam:7tm_1	33	290	1.9e-41	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218404

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219320

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agmo	C	T	12: 37,252,481	L106F	probably benign	Het
Appl1	A	G	14: 26,951,516	I208T	possibly damaging	Het
Arap2	G	T	5: 62,749,109	A189D	probably benign	Het
Arhgef12	T	C	9: 42,972,028	K1402E	possibly damaging	Het
C7	A	C	15: 5,049,560	F89V	probably damaging	Het
Camsap2	G	A	1: 136,281,123	T877I	probably damaging	Het
Cpt2	T	C	4: 107,907,386	T394A	probably benign	Het
Csnk2a1	G	T	2: 152,274,085		probably benign	Het
Dnah10	C	A	5: 124,798,014	T2528N	probably damaging	Het
Entpd8	G	T	2: 25,085,139	W494L	probably damaging	Het
Fam114a1	T	A	5: 65,005,792		probably benign	Het
Fat4	T	C	3: 38,889,295	V779A	probably damaging	Het
Gckr	T	C	5: 31,298,204	S34P	probably damaging	Het
Golga4	T	C	9: 118,535,460	V297A	probably benign	Het
Gps1	G	T	11: 120,786,823	A221S	probably damaging	Het
Heatr1	T	A	13: 12,433,986	S1861T	probably damaging	Het
Hmces	A	G	6: 87,925,729	E184G	probably damaging	Het
Itfg1	T	C	8: 85,725,511		probably null	Het
Mkl2	C	T	16: 13,403,156	T743I	possibly damaging	Het
Nfe2l3	A	G	6: 51,457,311	S284G	possibly damaging	Het
Nlrp2	C	A	7: 5,328,318	A360S	probably damaging	Het
Nop9	A	G	14: 55,750,076	H298R	probably benign	Het
Olfr1434	A	T	19: 12,283,983	S312C	possibly damaging	Het
Olfr183	T	A	16: 58,999,958	V91E	probably benign	Het
Olfr522	T	C	7: 140,162,374	D192G	possibly damaging	Het
Osgin1	A	G	8: 119,443,267	M158V	probably benign	Het
Patj	C	A	4: 98,426,064	Q374K	probably damaging	Het
Pck1	G	T	2: 173,156,004	G289W	probably damaging	Het
Phkg1	T	G	5: 129,866,054	I219L	possibly damaging	Het
Ppp1r15b	G	A	1: 133,133,343	A533T	probably damaging	Het
Ppwd1	T	C	13: 104,213,684	I398V	probably benign	Het
Prkdc	A	G	16: 15,833,666		probably benign	Het
Psg25	G	A	7: 18,526,287	L229F	possibly damaging	Het
Rps6ka1	T	A	4: 133,880,954	Q24L	probably benign	Het
Sgk3	T	C	1: 9,879,048	I147T	possibly damaging	Het
Slc25a24	T	A	3: 109,155,071	I159N	probably damaging	Het
Slc26a4	T	C	12: 31,522,527		probably null	Het
Slc35f4	T	C	14: 49,304,257	I347V	probably benign	Het
Spag17	A	T	3: 100,109,397	M2163L	probably benign	Het
Stab2	C	T	10: 86,950,269		probably benign	Het
Sult2a8	G	A	7: 14,411,705		probably benign	Het
Syne2	T	C	12: 76,031,546	L4718P	probably damaging	Het
Timd4	G	T	11: 46,815,694	G108W	probably damaging	Het
Timm9	T	C	12: 71,126,374		probably benign	Het
Vmn2r98	G	A	17: 19,066,013	V258I	probably benign	Het
Zcchc9	C	T	13: 91,800,881	V174I	probably benign	Het
Zdbf2	T	C	1: 63,303,077	V205A	possibly damaging	Het

Other mutations in Gpr65

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00435:Gpr65	APN	12	98275556	missense	probably damaging	1.00
IGL00717:Gpr65	APN	12	98276055	missense	probably benign	0.09
IGL01643:Gpr65	APN	12	98275754	missense	probably damaging	1.00
IGL01942:Gpr65	APN	12	98275715	missense	possibly damaging	0.93
IGL02023:Gpr65	APN	12	98275868	missense	probably benign	0.25
R1343:Gpr65	UTSW	12	98275629	missense	probably benign	0.00
R1520:Gpr65	UTSW	12	98275175	missense	probably benign	0.01
R1771:Gpr65	UTSW	12	98276000	missense	probably damaging	0.96
R1812:Gpr65	UTSW	12	98275742	missense	probably damaging	1.00
R2261:Gpr65	UTSW	12	98275235	missense	probably damaging	1.00
R2263:Gpr65	UTSW	12	98275235	missense	probably damaging	1.00
R5720:Gpr65	UTSW	12	98275102	missense	probably damaging	1.00
R7458:Gpr65	UTSW	12	98276065	missense	probably damaging	0.99
R8136:Gpr65	UTSW	12	98275156	missense	probably damaging	1.00
R9376:Gpr65	UTSW	12	98275264	missense	probably damaging	1.00

Posted On

2015-12-18