Incidental Mutation 'IGL03026:Olfr808'
ID408161
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr808
Ensembl Gene ENSMUSG00000049894
Gene Nameolfactory receptor 808
SynonymsGA_x6K02T2PULF-11446184-11447122, MOR112-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL03026
Quality Score
Status
Chromosome10
Chromosomal Location129765482-129771713 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 129768041 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 182 (M182L)
Ref Sequence ENSEMBL: ENSMUSP00000145315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060636] [ENSMUST00000203236]
Predicted Effect probably benign
Transcript: ENSMUST00000060636
AA Change: M182L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000059714
Gene: ENSMUSG00000049894
AA Change: M182L

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 1.8e-53 PFAM
Pfam:7tm_1 39 288 7.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203236
AA Change: M182L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000145315
Gene: ENSMUSG00000049894
AA Change: M182L

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 1.8e-53 PFAM
Pfam:7tm_1 39 288 7.7e-25 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly A G 11: 100,519,690 V154A possibly damaging Het
Adcy4 T C 14: 55,778,010 Y481C probably damaging Het
Adcy5 T C 16: 35,157,042 V315A probably benign Het
Atf7ip G A 6: 136,605,382 S1130N possibly damaging Het
Ctss A G 3: 95,538,830 D87G probably benign Het
Cwf19l2 A T 9: 3,428,777 K254N probably benign Het
Dnajc10 A G 2: 80,349,303 D727G probably damaging Het
Dsg3 G A 18: 20,536,972 probably null Het
Ehmt1 T C 2: 24,852,734 M478V probably benign Het
Enam A T 5: 88,503,299 N889I probably benign Het
Exo1 G T 1: 175,908,437 *148L probably null Het
Fam133b G T 5: 3,559,646 probably benign Het
Foxj2 G A 6: 122,838,180 A392T probably benign Het
Gbp4 G T 5: 105,120,000 A460E possibly damaging Het
Has3 A T 8: 106,878,610 I483F probably benign Het
Hist1h1b G A 13: 21,779,947 probably benign Het
Irak2 T A 6: 113,676,651 V260E probably damaging Het
Kcnj8 T C 6: 142,566,473 probably null Het
Lama5 A G 2: 180,195,967 V936A probably benign Het
Lmo7 C T 14: 101,929,333 probably benign Het
Morc3 T A 16: 93,862,724 probably benign Het
Muc6 T C 7: 141,640,147 probably benign Het
Nkx2-2 T C 2: 147,185,822 Y66C probably damaging Het
Oaz1 G A 10: 80,828,800 probably benign Het
Olfr1392 A T 11: 49,293,458 I46F probably damaging Het
Olfr768 G A 10: 129,093,188 A262V possibly damaging Het
Pkd2 A T 5: 104,494,887 probably benign Het
Plcb4 A G 2: 135,950,429 probably benign Het
Ralgapa2 C A 2: 146,460,775 probably benign Het
Rfx7 T C 9: 72,619,685 S1386P probably damaging Het
Ric1 T G 19: 29,599,833 W1046G probably benign Het
Rrp12 C A 19: 41,872,997 R957L probably damaging Het
Scn7a T C 2: 66,676,098 I1482M probably damaging Het
Sema3b T C 9: 107,602,063 N236S probably damaging Het
Skint6 T A 4: 112,991,244 probably null Het
Slfn5 T C 11: 82,956,561 Y91H probably benign Het
Sptbn2 T A 19: 4,724,233 probably null Het
Szt2 A G 4: 118,391,849 L546P probably benign Het
Tas1r3 A G 4: 155,861,843 probably benign Het
Trim75 A G 8: 64,983,786 V4A probably benign Het
Usp19 T C 9: 108,493,145 L56P probably damaging Het
Vmn1r181 T G 7: 23,984,575 I155S possibly damaging Het
Vmn2r43 G T 7: 8,255,097 D372E probably benign Het
Vstm2b C A 7: 40,902,521 S99* probably null Het
Wdr11 A G 7: 129,624,336 D735G probably damaging Het
Wee2 T A 6: 40,461,981 M346K probably benign Het
Zap70 A G 1: 36,779,717 K371R possibly damaging Het
Zfp990 A T 4: 145,537,110 H226L possibly damaging Het
Other mutations in Olfr808
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Olfr808 APN 10 129767586 missense probably null 0.99
IGL01313:Olfr808 APN 10 129767595 missense probably damaging 1.00
IGL01923:Olfr808 APN 10 129768104 missense probably benign 0.01
IGL02010:Olfr808 APN 10 129768267 missense probably benign 0.07
IGL02393:Olfr808 APN 10 129767793 missense probably benign 0.06
R1181:Olfr808 UTSW 10 129768164 missense probably benign 0.09
R1760:Olfr808 UTSW 10 129767548 missense probably benign 0.06
R1844:Olfr808 UTSW 10 129767856 missense probably benign 0.03
R2697:Olfr808 UTSW 10 129767924 missense probably benign 0.09
R3025:Olfr808 UTSW 10 129767673 missense probably damaging 1.00
R3414:Olfr808 UTSW 10 129768432 missense probably benign
R5824:Olfr808 UTSW 10 129768381 missense probably damaging 1.00
R6260:Olfr808 UTSW 10 129767520 missense probably benign 0.00
R6723:Olfr808 UTSW 10 129768415 missense probably benign 0.38
R6758:Olfr808 UTSW 10 129768051 missense probably damaging 0.97
R7305:Olfr808 UTSW 10 129767851 nonsense probably null
R7422:Olfr808 UTSW 10 129768267 missense possibly damaging 0.95
Posted On2016-08-02