Incidental Mutation 'IGL03026:Fam133b'
ID408182
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam133b
Ensembl Gene ENSMUSG00000058503
Gene Namefamily with sequence similarity 133, member B
Synonyms
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.547) question?
Stock #IGL03026
Quality Score
Status
Chromosome5
Chromosomal Location3543833-3570238 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) G to T at 3559646 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115527] [ENSMUST00000197082] [ENSMUST00000199666]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083110
Predicted Effect unknown
Transcript: ENSMUST00000115527
AA Change: R138L
SMART Domains Protein: ENSMUSP00000111189
Gene: ENSMUSG00000058503
AA Change: R138L

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 85 141 N/A INTRINSIC
low complexity region 145 166 N/A INTRINSIC
low complexity region 218 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196499
Predicted Effect unknown
Transcript: ENSMUST00000197082
AA Change: R138L
SMART Domains Protein: ENSMUSP00000142744
Gene: ENSMUSG00000058503
AA Change: R138L

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 85 158 N/A INTRINSIC
low complexity region 201 227 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198598
Predicted Effect probably benign
Transcript: ENSMUST00000199666
SMART Domains Protein: ENSMUSP00000143004
Gene: ENSMUSG00000058503

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 86 109 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly A G 11: 100,519,690 V154A possibly damaging Het
Adcy4 T C 14: 55,778,010 Y481C probably damaging Het
Adcy5 T C 16: 35,157,042 V315A probably benign Het
Atf7ip G A 6: 136,605,382 S1130N possibly damaging Het
Ctss A G 3: 95,538,830 D87G probably benign Het
Cwf19l2 A T 9: 3,428,777 K254N probably benign Het
Dnajc10 A G 2: 80,349,303 D727G probably damaging Het
Dsg3 G A 18: 20,536,972 probably null Het
Ehmt1 T C 2: 24,852,734 M478V probably benign Het
Enam A T 5: 88,503,299 N889I probably benign Het
Exo1 G T 1: 175,908,437 *148L probably null Het
Foxj2 G A 6: 122,838,180 A392T probably benign Het
Gbp4 G T 5: 105,120,000 A460E possibly damaging Het
Has3 A T 8: 106,878,610 I483F probably benign Het
Hist1h1b G A 13: 21,779,947 probably benign Het
Irak2 T A 6: 113,676,651 V260E probably damaging Het
Kcnj8 T C 6: 142,566,473 probably null Het
Lama5 A G 2: 180,195,967 V936A probably benign Het
Lmo7 C T 14: 101,929,333 probably benign Het
Morc3 T A 16: 93,862,724 probably benign Het
Muc6 T C 7: 141,640,147 probably benign Het
Nkx2-2 T C 2: 147,185,822 Y66C probably damaging Het
Oaz1 G A 10: 80,828,800 probably benign Het
Olfr1392 A T 11: 49,293,458 I46F probably damaging Het
Olfr768 G A 10: 129,093,188 A262V possibly damaging Het
Olfr808 A T 10: 129,768,041 M182L probably benign Het
Pkd2 A T 5: 104,494,887 probably benign Het
Plcb4 A G 2: 135,950,429 probably benign Het
Ralgapa2 C A 2: 146,460,775 probably benign Het
Rfx7 T C 9: 72,619,685 S1386P probably damaging Het
Ric1 T G 19: 29,599,833 W1046G probably benign Het
Rrp12 C A 19: 41,872,997 R957L probably damaging Het
Scn7a T C 2: 66,676,098 I1482M probably damaging Het
Sema3b T C 9: 107,602,063 N236S probably damaging Het
Skint6 T A 4: 112,991,244 probably null Het
Slfn5 T C 11: 82,956,561 Y91H probably benign Het
Sptbn2 T A 19: 4,724,233 probably null Het
Szt2 A G 4: 118,391,849 L546P probably benign Het
Tas1r3 A G 4: 155,861,843 probably benign Het
Trim75 A G 8: 64,983,786 V4A probably benign Het
Usp19 T C 9: 108,493,145 L56P probably damaging Het
Vmn1r181 T G 7: 23,984,575 I155S possibly damaging Het
Vmn2r43 G T 7: 8,255,097 D372E probably benign Het
Vstm2b C A 7: 40,902,521 S99* probably null Het
Wdr11 A G 7: 129,624,336 D735G probably damaging Het
Wee2 T A 6: 40,461,981 M346K probably benign Het
Zap70 A G 1: 36,779,717 K371R possibly damaging Het
Zfp990 A T 4: 145,537,110 H226L possibly damaging Het
Other mutations in Fam133b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01861:Fam133b APN 5 3564242 splice site probably benign
IGL03218:Fam133b APN 5 3554684 nonsense probably null
R0433:Fam133b UTSW 5 3558560 splice site probably benign
R1299:Fam133b UTSW 5 3554626 splice site probably benign
R3176:Fam133b UTSW 5 3558522 missense probably damaging 1.00
R3276:Fam133b UTSW 5 3558522 missense probably damaging 1.00
R3705:Fam133b UTSW 5 3561034 splice site probably benign
R4722:Fam133b UTSW 5 3543949 critical splice donor site probably null
R4799:Fam133b UTSW 5 3557815 missense probably damaging 0.99
R6151:Fam133b UTSW 5 3559133 missense probably null
R6709:Fam133b UTSW 5 3569059 utr 3 prime probably benign
R6835:Fam133b UTSW 5 3554732 missense possibly damaging 0.94
Posted On2016-08-02