Incidental Mutation 'IGL03221:Lilrb4b'
| ID |
413666 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lilrb4b
|
| Ensembl Gene |
ENSMUSG00000112023 |
| Gene Name |
leukocyte immunoglobulin-like receptor, subfamily B, member 4B |
| Synonyms |
gp49, Lilr4b, Gp49a |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
IGL03221
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
51356757-51362417 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 51357524 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151563
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102894]
[ENSMUST00000217706]
[ENSMUST00000218123]
[ENSMUST00000218704]
[ENSMUST00000219696]
[ENSMUST00000219960]
[ENSMUST00000219661]
|
| AlphaFold |
Q61450 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102894
|
| SMART Domains |
Protein: ENSMUSP00000099958
Gene: ENSMUSG00000112023
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
SCOP:d1nkr_2
|
24 |
118 |
3e-14 |
SMART |
|
Blast:IG_like
|
28 |
118 |
5e-49 |
BLAST |
|
Pfam:Ig_3
|
123 |
200 |
6.5e-8 |
PFAM |
|
Pfam:Ig_2
|
123 |
218 |
5.9e-8 |
PFAM |
|
Pfam:ig
|
127 |
211 |
8.4e-9 |
PFAM |
|
transmembrane domain
|
239 |
261 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139982
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000217706
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000218123
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218179
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218649
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000218704
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219262
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218900
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219717
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000219696
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000219960
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000219661
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219598
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219053
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219151
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp2b2 |
C |
T |
6: 113,737,820 (GRCm39) |
|
probably benign |
Het |
| BC051665 |
T |
A |
13: 60,932,242 (GRCm39) |
K116* |
probably null |
Het |
| Birc6 |
A |
T |
17: 74,934,002 (GRCm39) |
T2538S |
probably benign |
Het |
| Btn2a2 |
A |
G |
13: 23,662,619 (GRCm39) |
S435P |
probably damaging |
Het |
| Efhb |
A |
G |
17: 53,706,014 (GRCm39) |
L841P |
probably damaging |
Het |
| Etv4 |
C |
T |
11: 101,664,988 (GRCm39) |
R155K |
probably damaging |
Het |
| Fnbp4 |
T |
A |
2: 90,608,062 (GRCm39) |
M928K |
possibly damaging |
Het |
| Grin2c |
A |
G |
11: 115,144,870 (GRCm39) |
|
probably benign |
Het |
| Grip1 |
A |
T |
10: 119,822,299 (GRCm39) |
M342L |
probably benign |
Het |
| H60c |
T |
A |
10: 3,209,799 (GRCm39) |
K163* |
probably null |
Het |
| Hycc2 |
C |
A |
1: 58,579,345 (GRCm39) |
V231L |
probably benign |
Het |
| Lyl1 |
C |
T |
8: 85,429,300 (GRCm39) |
P3L |
possibly damaging |
Het |
| Mast4 |
A |
G |
13: 102,890,764 (GRCm39) |
V838A |
possibly damaging |
Het |
| Mypn |
C |
A |
10: 62,966,902 (GRCm39) |
D925Y |
probably damaging |
Het |
| Nol6 |
T |
C |
4: 41,124,166 (GRCm39) |
D27G |
probably benign |
Het |
| Or4c105 |
T |
C |
2: 88,647,781 (GRCm39) |
S89P |
possibly damaging |
Het |
| Or5b97 |
G |
T |
19: 12,878,905 (GRCm39) |
P80T |
probably damaging |
Het |
| Or8b51 |
A |
T |
9: 38,569,661 (GRCm39) |
V9E |
probably damaging |
Het |
| Pik3c2g |
A |
G |
6: 139,718,133 (GRCm39) |
|
probably null |
Het |
| Pik3c3 |
G |
T |
18: 30,435,984 (GRCm39) |
M394I |
probably benign |
Het |
| Rfx7 |
C |
T |
9: 72,526,088 (GRCm39) |
R1093C |
probably damaging |
Het |
| Scin |
A |
G |
12: 40,126,973 (GRCm39) |
V458A |
probably benign |
Het |
| Slc34a1 |
T |
C |
13: 55,548,591 (GRCm39) |
V39A |
probably benign |
Het |
| Slc6a4 |
A |
G |
11: 76,917,931 (GRCm39) |
M558V |
probably benign |
Het |
| Smpx |
T |
C |
X: 156,503,994 (GRCm39) |
V65A |
probably damaging |
Het |
| Tmem200a |
A |
T |
10: 25,869,922 (GRCm39) |
F116I |
possibly damaging |
Het |
| Tnfrsf19 |
A |
T |
14: 61,262,227 (GRCm39) |
V12E |
probably benign |
Het |
| Trpc1 |
C |
T |
9: 95,588,953 (GRCm39) |
R757H |
probably damaging |
Het |
| Ttc38 |
T |
A |
15: 85,718,742 (GRCm39) |
S51T |
probably benign |
Het |
| Wee1 |
G |
A |
7: 109,726,024 (GRCm39) |
C378Y |
probably damaging |
Het |
|
| Other mutations in Lilrb4b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00323:Lilrb4b
|
APN |
10 |
51,357,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02457:Lilrb4b
|
APN |
10 |
51,357,334 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03396:Lilrb4b
|
APN |
10 |
51,357,253 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0145:Lilrb4b
|
UTSW |
10 |
51,360,614 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Lilrb4b
|
UTSW |
10 |
51,357,389 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1313:Lilrb4b
|
UTSW |
10 |
51,356,832 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1543:Lilrb4b
|
UTSW |
10 |
51,357,517 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1984:Lilrb4b
|
UTSW |
10 |
51,357,831 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1985:Lilrb4b
|
UTSW |
10 |
51,357,831 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2243:Lilrb4b
|
UTSW |
10 |
51,357,704 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4094:Lilrb4b
|
UTSW |
10 |
51,357,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4887:Lilrb4b
|
UTSW |
10 |
51,360,616 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5588:Lilrb4b
|
UTSW |
10 |
51,357,422 (GRCm39) |
missense |
probably benign |
|
|
R6404:Lilrb4b
|
UTSW |
10 |
51,361,825 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8347:Lilrb4b
|
UTSW |
10 |
51,357,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9158:Lilrb4b
|
UTSW |
10 |
51,357,829 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9253:Lilrb4b
|
UTSW |
10 |
51,357,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Lilrb4b
|
UTSW |
10 |
51,356,801 (GRCm39) |
start gained |
probably benign |
|
|
R9400:Lilrb4b
|
UTSW |
10 |
51,357,319 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9673:Lilrb4b
|
UTSW |
10 |
51,357,753 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Lilrb4b
|
UTSW |
10 |
51,357,445 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation