Incidental Mutation 'IGL03291:Megf9'
ID415919
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Megf9
Ensembl Gene ENSMUSG00000039270
Gene Namemultiple EGF-like-domains 9
SynonymsEgfl5, 4933405H16Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock #IGL03291
Quality Score
Status
Chromosome4
Chromosomal Location70427065-70534995 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 70488150 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 260 (V260I)
Ref Sequence ENSEMBL: ENSMUSP00000040801 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037881] [ENSMUST00000107359]
Predicted Effect probably benign
Transcript: ENSMUST00000037881
AA Change: V260I

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000040801
Gene: ENSMUSG00000039270
AA Change: V260I

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
low complexity region 150 166 N/A INTRINSIC
low complexity region 183 199 N/A INTRINSIC
EGF_Lam 202 252 3.97e-9 SMART
TNFR 236 271 3.38e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107359
AA Change: V260I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000102982
Gene: ENSMUSG00000039270
AA Change: V260I

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
low complexity region 150 166 N/A INTRINSIC
low complexity region 183 199 N/A INTRINSIC
EGF_Lam 202 249 2.8e-9 SMART
TNFR 236 272 1.26e-1 SMART
EGF_Lam 252 296 2.13e-9 SMART
EGF_Lam 299 344 1.42e-10 SMART
EGF_Lam 347 395 6.3e-3 SMART
EGF_Lam 398 447 3.05e-10 SMART
transmembrane domain 513 535 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano1 T A 7: 144,621,675 E502V probably damaging Het
Atic T C 1: 71,570,922 V364A probably benign Het
Cfap44 A T 16: 44,407,311 H125L possibly damaging Het
Ctnna2 T A 6: 76,973,712 E227V probably damaging Het
Ctsf A G 19: 4,859,634 I378V probably benign Het
Eya1 C T 1: 14,184,348 probably null Het
Fat2 C T 11: 55,262,595 R3597H probably benign Het
Gdpd5 T C 7: 99,460,121 probably benign Het
Glcci1 T A 6: 8,579,678 I293K probably damaging Het
Gm16503 T A 4: 147,541,078 Y10N unknown Het
Gm5930 A T 14: 44,331,448 I239N possibly damaging Het
Grm5 T C 7: 88,130,796 L1148P probably damaging Het
Kmt2e T A 5: 23,499,291 L1161I probably damaging Het
Mme T A 3: 63,346,104 D456E probably benign Het
Mup8 T A 4: 60,221,950 E61V probably damaging Het
Olfml1 A G 7: 107,590,229 D167G probably damaging Het
Olfr615 T A 7: 103,560,912 M145K possibly damaging Het
Piezo2 T C 18: 63,021,308 K2467E probably damaging Het
Plscr1 T A 9: 92,266,870 F254L probably damaging Het
Prol1 A T 5: 88,328,520 K256N unknown Het
Rapgef4 A T 2: 72,195,703 L339F probably damaging Het
Slc27a2 T C 2: 126,564,750 I118T probably benign Het
Smim7 A T 8: 72,569,994 F19L possibly damaging Het
Svil T A 18: 5,056,150 L428* probably null Het
Tcof1 T C 18: 60,829,061 T699A possibly damaging Het
Thsd7b T A 1: 129,760,355 S668T possibly damaging Het
Tmprss7 T C 16: 45,680,748 D230G probably benign Het
Tyw1 A G 5: 130,299,993 D540G probably damaging Het
Zfp763 A G 17: 33,019,886 V95A probably damaging Het
Other mutations in Megf9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01604:Megf9 APN 4 70448791 missense probably null 1.00
IGL01697:Megf9 APN 4 70433472 missense possibly damaging 0.65
R0020:Megf9 UTSW 4 70488149 missense probably benign 0.45
R0325:Megf9 UTSW 4 70455941 missense probably damaging 1.00
R0542:Megf9 UTSW 4 70435348 missense probably benign
R1144:Megf9 UTSW 4 70534624 missense probably benign 0.10
R1843:Megf9 UTSW 4 70534785 missense probably damaging 1.00
R2085:Megf9 UTSW 4 70448767 missense probably damaging 1.00
R2168:Megf9 UTSW 4 70433442 missense probably damaging 0.99
R4656:Megf9 UTSW 4 70448767 missense probably damaging 1.00
R4718:Megf9 UTSW 4 70448778 missense possibly damaging 0.49
R4832:Megf9 UTSW 4 70534428 missense probably damaging 0.99
R6573:Megf9 UTSW 4 70488172 nonsense probably null
R6978:Megf9 UTSW 4 70433529 missense probably benign 0.12
R7243:Megf9 UTSW 4 70435471 missense probably benign 0.03
R7481:Megf9 UTSW 4 70433442 missense probably damaging 0.99
R8063:Megf9 UTSW 4 70488258 missense probably damaging 1.00
R8460:Megf9 UTSW 4 70455971 missense probably damaging 1.00
Posted On2016-08-02