Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03094:Tmem225'

418483

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem225

Ensembl Gene

ENSMUSG00000040541

Gene Name

transmembrane protein 225

Synonyms

1700030E15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL03094

Quality Score

Status

Chromosome

Chromosomal Location

40059418-40062170 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 40059682 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 21 (I21L)

Ref Sequence

ENSEMBL: ENSMUSP00000036816 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046333]

AlphaFold

Q9D9S2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000046333
AA Change: I21L

PolyPhen 2 Score 0.455 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000036816
Gene: ENSMUSG00000040541
AA Change: I21L

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
transmembrane domain	97	119	N/A	INTRINSIC
transmembrane domain	139	161	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,074,938 (GRCm39)	N1375S	probably benign	Het
Adamts15	A	T	9: 30,815,768 (GRCm39)		probably benign	Het
Ahnak	G	A	19: 8,980,911 (GRCm39)	V732M	possibly damaging	Het
Akr1c19	G	A	13: 4,286,184 (GRCm39)	V61I	probably benign	Het
BC025920	C	A	10: 81,444,906 (GRCm39)	R10S	probably benign	Het
Cdh11	T	C	8: 103,385,035 (GRCm39)	I347V	probably benign	Het
Cyp11b2	A	G	15: 74,724,886 (GRCm39)		probably null	Het
Cyp4a31	T	A	4: 115,435,305 (GRCm39)		probably benign	Het
Emilin3	G	A	2: 160,750,649 (GRCm39)	Q320*	probably null	Het
Glra3	C	A	8: 56,578,207 (GRCm39)	H421Q	probably benign	Het
Gtf2f1	T	C	17: 57,314,049 (GRCm39)	N145S	probably damaging	Het
Hsd17b12	A	T	2: 93,864,339 (GRCm39)	V256E	probably damaging	Het
Ighv1-34	C	T	12: 114,814,958 (GRCm39)	G68E	probably damaging	Het
Ipo5	T	C	14: 121,181,089 (GRCm39)		probably benign	Het
Knop1	T	A	7: 118,452,374 (GRCm39)	D63V	possibly damaging	Het
Krt39	T	C	11: 99,411,628 (GRCm39)		probably benign	Het
Ldhb	T	C	6: 142,451,253 (GRCm39)	K5R	probably benign	Het
Loxhd1	A	T	18: 77,518,809 (GRCm39)	I1872F	possibly damaging	Het
Lrfn5	A	G	12: 61,886,532 (GRCm39)	N107D	probably benign	Het
Mks1	A	G	11: 87,746,291 (GRCm39)		probably benign	Het
Nup93	C	T	8: 95,023,130 (GRCm39)	T236I	probably benign	Het
Olig3	T	C	10: 19,232,878 (GRCm39)	S168P	probably benign	Het
Or1i2	A	G	10: 78,447,953 (GRCm39)	I174T	possibly damaging	Het
Pcna	C	T	2: 132,093,673 (GRCm39)	E109K	probably benign	Het
Per3	A	C	4: 151,093,755 (GRCm39)	I1020R	probably damaging	Het
Plbd2	T	C	5: 120,624,845 (GRCm39)	N441S	probably damaging	Het
Plec	A	G	15: 76,075,519 (GRCm39)	S398P	probably damaging	Het
Ppm1m	T	G	9: 106,073,610 (GRCm39)	K314T	probably damaging	Het
Prmt2	T	A	10: 76,046,224 (GRCm39)		probably benign	Het
Rbm19	T	C	5: 120,261,023 (GRCm39)	S216P	probably damaging	Het
Sart1	A	G	19: 5,434,109 (GRCm39)		probably benign	Het
Tnnt2	T	C	1: 135,777,200 (GRCm39)		probably null	Het
Trappc10	A	T	10: 78,064,754 (GRCm39)		probably benign	Het
Trip13	A	G	13: 74,081,075 (GRCm39)	L97P	probably benign	Het
Zmat2	T	G	18: 36,929,119 (GRCm39)	V89G	probably damaging	Het

Other mutations in Tmem225

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01833:Tmem225	APN	9	40,059,725 (GRCm39)	missense	probably damaging	0.98
R0599:Tmem225	UTSW	9	40,061,043 (GRCm39)	missense	possibly damaging	0.46
R1134:Tmem225	UTSW	9	40,061,143 (GRCm39)	missense	possibly damaging	0.92
R2842:Tmem225	UTSW	9	40,061,097 (GRCm39)	missense	probably damaging	0.99
R4556:Tmem225	UTSW	9	40,060,762 (GRCm39)	missense	probably damaging	0.96
R5024:Tmem225	UTSW	9	40,060,639 (GRCm39)	missense	probably benign	0.01
R5526:Tmem225	UTSW	9	40,062,002 (GRCm39)	missense	possibly damaging	0.92
R5540:Tmem225	UTSW	9	40,060,681 (GRCm39)	missense	probably damaging	0.99
R5597:Tmem225	UTSW	9	40,060,726 (GRCm39)	missense	possibly damaging	0.94
R6267:Tmem225	UTSW	9	40,059,731 (GRCm39)	missense	probably damaging	0.97
R6314:Tmem225	UTSW	9	40,062,016 (GRCm39)	missense	probably benign
R7153:Tmem225	UTSW	9	40,059,664 (GRCm39)	missense	probably benign	0.01
R8031:Tmem225	UTSW	9	40,060,689 (GRCm39)	missense	possibly damaging	0.46
R8245:Tmem225	UTSW	9	40,061,955 (GRCm39)	missense	probably damaging	0.99
X0064:Tmem225	UTSW	9	40,061,082 (GRCm39)	missense	possibly damaging	0.85

Posted On

2016-08-02