Mutagenetix > Incidental Mutation

Incidental Mutation 'R8670:Armh2'

661118

Institutional Source

Beutler Lab

Gene Symbol

Armh2

Ensembl Gene

ENSMUSG00000085861

Gene Name

armadillo-like helical domain containing 2

Synonyms

1700016G14Rik

MMRRC Submission

068525-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R8670 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

24925215-24930575 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 24930240 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 162 (E162G)

Ref Sequence

ENSEMBL: ENSMUSP00000153199 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000136906]

AlphaFold

A0A286YCZ6

Predicted Effect

probably benign
Transcript: ENSMUST00000136906
AA Change: E162G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 96.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	A	T	11: 109,966,424 (GRCm39)	L403Q	probably damaging	Het
Actl11	T	C	9: 107,805,959 (GRCm39)	F94S	possibly damaging	Het
Adam34	C	T	8: 44,105,126 (GRCm39)	C173Y	possibly damaging	Het
Ankrd24	C	T	10: 81,465,526 (GRCm39)		probably benign	Het
Atp12a	A	T	14: 56,617,546 (GRCm39)	D612V	probably damaging	Het
Cacna2d1	T	C	5: 16,140,013 (GRCm39)	M1T	probably null	Het
Ccdc178	T	C	18: 22,230,719 (GRCm39)	E384G	possibly damaging	Het
Cd82	T	A	2: 93,250,905 (GRCm39)	T212S	probably benign	Het
Cdk17	T	A	10: 93,061,958 (GRCm39)	L263*	probably null	Het
Cfap57	T	G	4: 118,472,122 (GRCm39)	I86L	possibly damaging	Het
Chd5	T	C	4: 152,469,953 (GRCm39)	M1842T	possibly damaging	Het
Clcn7	T	C	17: 25,378,588 (GRCm39)	F691S	probably damaging	Het
Cpvl	A	T	6: 53,951,780 (GRCm39)	M1K	probably null	Het
Cym	T	C	3: 107,118,812 (GRCm39)		probably null	Het
Diaph3	T	C	14: 86,893,835 (GRCm39)	E1147G	probably benign	Het
Eif4g3	T	G	4: 137,885,823 (GRCm39)		probably null	Het
Esp3	A	G	17: 40,943,040 (GRCm39)	D11G	probably benign	Het
Exoc1	A	G	5: 76,717,505 (GRCm39)	Y865C	probably damaging	Het
Flg2	A	T	3: 93,108,791 (GRCm39)	Q273L	probably damaging	Het
Fuca1	G	A	4: 135,650,282 (GRCm39)	V118I	possibly damaging	Het
Gga3	T	C	11: 115,478,542 (GRCm39)	N417D	probably benign	Het
Il1rl1	A	T	1: 40,480,559 (GRCm39)	I63F	probably damaging	Het
Kif26b	A	G	1: 178,741,349 (GRCm39)	Y785C	probably damaging	Het
Kif5b	A	C	18: 6,214,631 (GRCm39)	S599A	probably benign	Het
Klhl22	T	A	16: 17,594,327 (GRCm39)	I152N	probably damaging	Het
Mex3c	GC	G	18: 73,722,776 (GRCm39)		probably null	Het
Muc21	T	A	17: 35,932,540 (GRCm39)	T549S	unknown	Het
Or52n2c	A	T	7: 104,574,419 (GRCm39)	M184K	probably damaging	Het
Or8g2	A	G	9: 39,821,719 (GRCm39)	I207V	probably benign	Het
Orc3	A	T	4: 34,572,529 (GRCm39)	I633N	probably damaging	Het
Pclo	G	A	5: 14,732,061 (GRCm39)	R3521H	unknown	Het
Plec	A	G	15: 76,061,726 (GRCm39)	L2737P	probably damaging	Het
Prom1	T	A	5: 44,159,186 (GRCm39)	I813F	probably benign	Het
Prpf40b	T	A	15: 99,207,621 (GRCm39)	M517K	probably damaging	Het
Rab8a	TA	TAA	8: 72,925,130 (GRCm39)		probably null	Het
Rnf213	T	C	11: 119,349,563 (GRCm39)	L3808P		Het
Scnn1b	A	G	7: 121,498,472 (GRCm39)	K4R	probably benign	Het
Siglec1	A	G	2: 130,923,387 (GRCm39)	S453P	probably damaging	Het
Sim1	A	G	10: 50,784,849 (GRCm39)	K165E	probably damaging	Het
Slc49a4	G	T	16: 35,556,005 (GRCm39)	Q152K	possibly damaging	Het
Slco1a7	G	A	6: 141,711,468 (GRCm39)	T81I	possibly damaging	Het
Smarce1	T	C	11: 99,101,098 (GRCm39)	T345A	possibly damaging	Het
Spty2d1	T	C	7: 46,647,519 (GRCm39)	N470S	probably benign	Het
Stab2	T	A	10: 86,776,587 (GRCm39)	D763V	probably damaging	Het
Tbl1xr1	A	T	3: 22,245,164 (GRCm39)	E171D	probably damaging	Het
Tenm4	C	T	7: 96,555,148 (GRCm39)	P2618S	probably benign	Het
Tex15	T	A	8: 34,064,746 (GRCm39)	I1392K	probably benign	Het
Thada	T	C	17: 84,739,774 (GRCm39)	E827G	probably benign	Het
Ttc3	A	G	16: 94,191,067 (GRCm39)	Y185C	probably damaging	Het
Vmn2r18	C	A	5: 151,485,854 (GRCm39)	D547Y	probably damaging	Het
Wdpcp	T	C	11: 21,645,196 (GRCm39)	V208A	probably benign	Het
Zfp322a	T	A	13: 23,541,274 (GRCm39)	Q156L	possibly damaging	Het
Zfp947	T	C	17: 22,364,687 (GRCm39)	D329G	probably benign	Het

Other mutations in Armh2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4792:Armh2	UTSW	13	24,930,490 (GRCm39)	utr 3 prime	probably benign
R7135:Armh2	UTSW	13	24,925,489 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCTTCCAGGAGGCATGAGTG -3'
(R):5'- CGGCAAAATTTTCAGGCCACC -3'

Sequencing Primer
(F):5'- ATGAGTGCCGCGCAGTTC -3'
(R):5'- CCAGACCAGTTCTCCGTAGC -3'

Posted On

2021-03-08