Incidental Mutation 'R9496:Fcgr3'
ID 717204
Institutional Source Beutler Lab
Gene Symbol Fcgr3
Ensembl Gene ENSMUSG00000059498
Gene Name Fc receptor, IgG, low affinity III
Synonyms FcgammaRIII, CD16, Fcg receptor III
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9496 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 170878743-170892504 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 170879386 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Aspartic acid at position 219 (Y219D)
Ref Sequence ENSEMBL: ENSMUSP00000131938 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164044] [ENSMUST00000169017]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000164044
AA Change: Y219D

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131938
Gene: ENSMUSG00000059498
AA Change: Y219D

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
IG 47 120 1.2e-1 SMART
IG 128 206 1.24e-8 SMART
transmembrane domain 219 241 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000169017
AA Change: Y218D

PolyPhen 2 Score 0.567 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000131836
Gene: ENSMUSG00000059498
AA Change: Y218D

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
IG 46 119 1.2e-1 SMART
IG 127 205 1.24e-8 SMART
transmembrane domain 218 240 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
PHENOTYPE: Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg2a A T 19: 6,310,022 (GRCm39) Q1735L possibly damaging Het
Brpf3 A G 17: 29,040,453 (GRCm39) D958G probably benign Het
Cacna1g A G 11: 94,356,711 (GRCm39) F142L probably benign Het
Calcoco1 C T 15: 102,619,876 (GRCm39) A303T probably benign Het
Chat C A 14: 32,148,119 (GRCm39) C306F probably benign Het
Ciita T G 16: 10,298,009 (GRCm39) M1R probably null Het
Ckap2l A C 2: 129,112,595 (GRCm39) S638A probably benign Het
Coro1c C T 5: 113,983,337 (GRCm39) G397D probably benign Het
Cyb5r2 A G 7: 107,353,954 (GRCm39) V72A probably damaging Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Dcbld2 A G 16: 58,271,164 (GRCm39) T314A probably benign Het
Dcun1d4 T G 5: 73,668,272 (GRCm39) H37Q probably damaging Het
Dgkd T A 1: 87,857,464 (GRCm39) S725R probably benign Het
Dhx29 T C 13: 113,089,460 (GRCm39) Y744H probably damaging Het
Ect2l T C 10: 18,004,885 (GRCm39) N916S probably damaging Het
Ep400 T C 5: 110,855,853 (GRCm39) K1287E unknown Het
Epo C T 5: 137,482,401 (GRCm39) V89I probably benign Het
Fbxw15 A T 9: 109,397,291 (GRCm39) I3N probably benign Het
Fign A T 2: 63,809,253 (GRCm39) C672* probably null Het
Fsip2 A T 2: 82,793,062 (GRCm39) R406S probably benign Het
Gli2 A G 1: 118,764,425 (GRCm39) V1242A probably benign Het
Gm10577 C T 4: 100,877,745 (GRCm39) C50Y unknown Het
Gm11568 GCTGCTGCCAGCCCTGCTGCCAGCCC GCTGCTGCCAGCCCTGCTGCCAGCCCTGCTGCCAGCCC 11: 99,749,044 (GRCm39) probably benign Het
Grid1 T C 14: 35,291,571 (GRCm39) L826P probably damaging Het
Hmcn1 T C 1: 150,579,971 (GRCm39) D1922G probably benign Het
Itga2b C T 11: 102,358,629 (GRCm39) C96Y probably damaging Het
Itih2 A T 2: 10,106,984 (GRCm39) I670N probably benign Het
Lypla1 A T 1: 4,898,813 (GRCm39) probably benign Het
Mettl16 T C 11: 74,707,696 (GRCm39) S337P possibly damaging Het
Myh11 G A 16: 14,048,616 (GRCm39) Q564* probably null Het
Myrf A G 19: 10,193,840 (GRCm39) F529L probably benign Het
Nell2 T G 15: 95,194,097 (GRCm39) I539L probably benign Het
Nfxl1 A T 5: 72,685,502 (GRCm39) V646E possibly damaging Het
Nin T C 12: 70,102,762 (GRCm39) T289A Het
Obsl1 C T 1: 75,467,484 (GRCm39) C1430Y probably damaging Het
Otog T C 7: 45,890,505 (GRCm39) L18P unknown Het
Pkd1l1 C A 11: 8,783,773 (GRCm39) probably null Het
Pum1 T C 4: 130,446,664 (GRCm39) probably null Het
Rhbdl1 A T 17: 26,055,371 (GRCm39) probably null Het
Rmdn2 T A 17: 79,975,425 (GRCm39) L305I possibly damaging Het
Scn3a A G 2: 65,312,493 (GRCm39) probably null Het
Shtn1 G T 19: 58,963,457 (GRCm39) S619R probably damaging Het
Smpd1 G A 7: 105,205,202 (GRCm39) probably null Het
Tepsin A G 11: 119,982,357 (GRCm39) L571S probably damaging Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Tssk5 T C 15: 76,258,856 (GRCm39) D10G probably benign Het
Usp39 A G 6: 72,302,759 (GRCm39) Y432H probably benign Het
Vmn2r97 T A 17: 19,149,227 (GRCm39) V205D probably damaging Het
Vwa8 T C 14: 79,258,122 (GRCm39) V757A probably benign Het
Zc2hc1b A T 10: 13,044,540 (GRCm39) F41Y probably damaging Het
Zfp1007 A G 5: 109,823,924 (GRCm39) S509P probably damaging Het
Zfp114 A T 7: 23,880,463 (GRCm39) S271C possibly damaging Het
Other mutations in Fcgr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01653:Fcgr3 APN 1 170,886,849 (GRCm39) missense probably damaging 1.00
PIT4696001:Fcgr3 UTSW 1 170,885,319 (GRCm39) missense probably damaging 1.00
R1722:Fcgr3 UTSW 1 170,881,688 (GRCm39) missense possibly damaging 0.89
R3734:Fcgr3 UTSW 1 170,885,443 (GRCm39) missense probably benign 0.04
R4207:Fcgr3 UTSW 1 170,881,644 (GRCm39) missense probably benign 0.29
R5885:Fcgr3 UTSW 1 170,885,280 (GRCm39) missense probably damaging 1.00
R7237:Fcgr3 UTSW 1 170,886,870 (GRCm39) missense probably damaging 1.00
R7429:Fcgr3 UTSW 1 170,885,442 (GRCm39) missense probably benign
R7514:Fcgr3 UTSW 1 170,886,912 (GRCm39) missense probably benign 0.01
R7692:Fcgr3 UTSW 1 170,881,661 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAAAGGAAGGCTGTGTGGC -3'
(R):5'- GAAGGCTTCCTGACTTATTGTCTG -3'

Sequencing Primer
(F):5'- TGAAAAGTTGCTGCTGCCAC -3'
(R):5'- GCTCTTGTCCTTAGTTTAAGACCTTG -3'
Posted On 2022-07-18