Mutagenetix > Incidental Mutation

Incidental Mutation 'R9504:Sult3a2'

717732

Institutional Source

Beutler Lab

Gene Symbol

Sult3a2

Ensembl Gene

ENSMUSG00000090298

Gene Name

sulfotransferase family 3A, member 2

Synonyms

Gm4794

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.130) question?

Stock #

R9504 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

33642420-33662700 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 33642436 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 289 (N289S)

Ref Sequence

ENSEMBL: ENSMUSP00000127159 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165904] [ENSMUST00000223295]

AlphaFold

G5E904

Predicted Effect

probably benign
Transcript: ENSMUST00000165904
AA Change: N289S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000127159
Gene: ENSMUSG00000090298
AA Change: N289S

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	36	283	8.9e-80	PFAM
Pfam:Sulfotransfer_3	37	207	6.8e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000223295
AA Change: N289S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1b1	T	C	4: 45,802,905 (GRCm39)	Y148H	probably damaging	Het
Ankib1	A	G	5: 3,763,235 (GRCm39)	V498A	probably benign	Het
Atp6v0c	A	G	17: 24,383,493 (GRCm39)	V118A	possibly damaging	Het
Bcan	G	A	3: 87,900,748 (GRCm39)	P495L	probably benign	Het
Bnip3l	G	A	14: 67,246,214 (GRCm39)	P7L	possibly damaging	Het
Ccdc178	T	C	18: 22,238,708 (GRCm39)	E303G	possibly damaging	Het
Ccdc47	T	C	11: 106,101,155 (GRCm39)	N169S	probably benign	Het
Cldn23	A	T	8: 36,293,470 (GRCm39)	V6E	probably damaging	Het
Dip2a	T	C	10: 76,132,189 (GRCm39)	T560A	probably damaging	Het
Ephb3	A	G	16: 21,036,830 (GRCm39)	S352G	possibly damaging	Het
Far2	C	A	6: 148,059,453 (GRCm39)	A256E	probably damaging	Het
Gga1	C	T	15: 78,767,528 (GRCm39)	R89C	probably damaging	Het
Hbb-bh2	A	G	7: 103,489,339 (GRCm39)	S71P	probably damaging	Het
Lama1	T	A	17: 68,128,661 (GRCm39)	V3006D		Het
Lypd9	A	G	11: 58,337,215 (GRCm39)	V86A	probably benign	Het
Mrm1	G	A	11: 84,710,132 (GRCm39)	R23W	probably damaging	Het
Nod2	A	T	8: 89,391,906 (GRCm39)	I738F	probably damaging	Het
Or1p1b	C	T	11: 74,131,094 (GRCm39)	R235C	probably benign	Het
Or4c35	G	T	2: 89,808,497 (GRCm39)	C125F	probably damaging	Het
Or8b4	A	G	9: 37,830,163 (GRCm39)	D70G	probably damaging	Het
Pkd1l1	A	G	11: 8,815,631 (GRCm39)	W1877R		Het
Psmd2	C	T	16: 20,478,160 (GRCm39)	A515V	probably benign	Het
Samd9l	A	G	6: 3,372,621 (GRCm39)	Y1547H	probably benign	Het
Sgsh	T	C	11: 119,237,375 (GRCm39)	N413S	probably benign	Het
Slmap	G	A	14: 26,136,133 (GRCm39)	P819L	probably damaging	Het
Steap4	A	G	5: 8,030,538 (GRCm39)	N465D	probably benign	Het
Tbx2	T	A	11: 85,724,038 (GRCm39)	S36T	possibly damaging	Het
Tcstv1a	G	A	13: 120,355,267 (GRCm39)	Q122*	probably null	Het
Tnk2	T	C	16: 32,498,961 (GRCm39)	V758A	possibly damaging	Het
Trrap	C	T	5: 144,742,904 (GRCm39)	T1425M	probably damaging	Het
Ttc9b	A	G	7: 27,354,394 (GRCm39)	K160R	probably damaging	Het
Vinac1	C	T	2: 128,881,189 (GRCm39)	A246T		Het
Zfp959	T	A	17: 56,204,793 (GRCm39)	Y277N	probably benign	Het

Other mutations in Sult3a2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02510:Sult3a2	APN	10	33,642,435 (GRCm39)	missense	probably benign	0.01
IGL03106:Sult3a2	APN	10	33,655,769 (GRCm39)	missense	probably benign	0.25
H8441:Sult3a2	UTSW	10	33,642,474 (GRCm39)	missense	probably benign	0.00
R0002:Sult3a2	UTSW	10	33,655,803 (GRCm39)	missense	possibly damaging	0.95
R0602:Sult3a2	UTSW	10	33,658,044 (GRCm39)	missense	probably benign	0.04
R1170:Sult3a2	UTSW	10	33,653,188 (GRCm39)	missense	possibly damaging	0.87
R1510:Sult3a2	UTSW	10	33,658,026 (GRCm39)	missense	probably benign	0.03
R1572:Sult3a2	UTSW	10	33,657,973 (GRCm39)	missense	probably damaging	1.00
R1725:Sult3a2	UTSW	10	33,655,705 (GRCm39)	missense	probably benign	0.00
R4601:Sult3a2	UTSW	10	33,658,083 (GRCm39)	missense	probably benign	0.00
R5570:Sult3a2	UTSW	10	33,654,268 (GRCm39)	missense	probably damaging	1.00
R6529:Sult3a2	UTSW	10	33,655,733 (GRCm39)	missense	probably damaging	1.00
R7996:Sult3a2	UTSW	10	33,644,254 (GRCm39)	missense	probably damaging	1.00
R8255:Sult3a2	UTSW	10	33,655,747 (GRCm39)	missense	probably benign	0.04
R8531:Sult3a2	UTSW	10	33,653,239 (GRCm39)	missense	probably damaging	1.00
R8982:Sult3a2	UTSW	10	33,658,069 (GRCm39)	missense	probably damaging	0.97
R9018:Sult3a2	UTSW	10	33,655,689 (GRCm39)	missense	probably benign	0.03
R9546:Sult3a2	UTSW	10	33,655,670 (GRCm39)	missense	possibly damaging	0.62
V1024:Sult3a2	UTSW	10	33,642,474 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCCCTTTGAAAGTCATGTTATGGC -3'
(R):5'- AGGAGAGGTATCCATCTGATCCC -3'

Sequencing Primer
(F):5'- GTCATGTTATGGCAAACAATCTAGGC -3'
(R):5'- AGGTATCCATCTGATCCCTACTAAGG -3'

Posted On

2022-07-18