Incidental Mutation 'R9583:Or4a77'
ID 722639
Institutional Source Beutler Lab
Gene Symbol Or4a77
Ensembl Gene ENSMUSG00000075078
Gene Name olfactory receptor family 4 subfamily A member 77
Synonyms GA_x6K02T2Q125-51098877-51097933, MOR231-7, Olfr1250
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R9583 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 89486839-89487783 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89487005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 260 (V260A)
Ref Sequence ENSEMBL: ENSMUSP00000107152 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099768] [ENSMUST00000111527] [ENSMUST00000215730]
AlphaFold Q8VGM3
Predicted Effect possibly damaging
Transcript: ENSMUST00000099768
AA Change: V260A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097356
Gene: ENSMUSG00000075078
AA Change: V260A

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.1e-28 PFAM
Pfam:7tm_4 137 278 1e-38 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000111527
AA Change: V260A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107152
Gene: ENSMUSG00000075078
AA Change: V260A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.2e-50 PFAM
Pfam:7tm_1 39 285 8.1e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215730
AA Change: V260A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik A T 10: 28,862,092 (GRCm39) I66N probably damaging Het
Adgrg3 A T 8: 95,760,071 (GRCm39) I97F probably benign Het
AI987944 T A 7: 41,023,937 (GRCm39) R350S probably benign Het
Arap3 T C 18: 38,109,096 (GRCm39) T1214A probably damaging Het
Arid5a A G 1: 36,356,739 (GRCm39) E127G possibly damaging Het
Bbx T C 16: 50,044,920 (GRCm39) E547G possibly damaging Het
Ceacam16 T C 7: 19,587,803 (GRCm39) I322V probably damaging Het
Chd2 G T 7: 73,130,230 (GRCm39) N808K probably damaging Het
Copg2 A C 6: 30,787,399 (GRCm39) L615* probably null Het
Cyp21a1 A G 17: 35,022,017 (GRCm39) L221P probably damaging Het
Dnah9 C A 11: 65,856,507 (GRCm39) V2885L probably damaging Het
Dnajb13 A G 7: 100,152,446 (GRCm39) L290P probably damaging Het
Eif3e A G 15: 43,128,957 (GRCm39) V221A probably damaging Het
Evc G A 5: 37,473,701 (GRCm39) R511* probably null Het
Far2 C T 6: 148,059,434 (GRCm39) P250S probably damaging Het
Fmo1 T A 1: 162,686,996 (GRCm39) T44S Het
Grid1 A G 14: 35,302,492 (GRCm39) E919G possibly damaging Het
Grip1 G A 10: 119,874,569 (GRCm39) E778K possibly damaging Het
Hoxb2 A G 11: 96,242,725 (GRCm39) E30G probably damaging Het
Il5ra G A 6: 106,689,331 (GRCm39) P75L unknown Het
Il5ra T A 6: 106,721,297 (GRCm39) M1L possibly damaging Het
Inpp4b T C 8: 82,497,555 (GRCm39) probably null Het
Itgb8 T A 12: 119,153,708 (GRCm39) H269L possibly damaging Het
Jrk G A 15: 74,578,403 (GRCm39) A294V probably damaging Het
Knl1 A T 2: 118,887,782 (GRCm39) D2V probably damaging Het
Lrrc71 T C 3: 87,650,258 (GRCm39) I272V possibly damaging Het
Mdn1 T C 4: 32,741,372 (GRCm39) S3825P probably damaging Het
Mex3d C A 10: 80,218,129 (GRCm39) V363L Het
Mfsd13b C A 7: 120,598,134 (GRCm39) H347N possibly damaging Het
Mllt1 G T 17: 57,209,572 (GRCm39) H179Q probably benign Het
Mmp14 A T 14: 54,678,069 (GRCm39) R563S probably benign Het
Ms4a18 T C 19: 10,974,714 (GRCm39) T326A probably benign Het
Muc16 T C 9: 18,549,973 (GRCm39) D5440G probably benign Het
Muc2 A T 7: 141,300,559 (GRCm39) E294V Het
Myh7b A G 2: 155,459,641 (GRCm39) N241S probably damaging Het
Myo1b T C 1: 51,796,404 (GRCm39) I1007V possibly damaging Het
Or10j5 T C 1: 172,784,893 (GRCm39) F177S probably damaging Het
Or8g33 T A 9: 39,337,851 (GRCm39) D172V possibly damaging Het
Pan2 T C 10: 128,140,135 (GRCm39) S19P probably benign Het
Pkn3 A G 2: 29,976,723 (GRCm39) D588G probably null Het
Pkp4 A G 2: 59,178,104 (GRCm39) N988D possibly damaging Het
Plxdc1 T C 11: 97,824,844 (GRCm39) D344G probably damaging Het
Plxna4 C T 6: 32,192,169 (GRCm39) R807H possibly damaging Het
Potefam3b T A 8: 21,174,962 (GRCm39) F285I possibly damaging Het
Prdm15 A T 16: 97,623,142 (GRCm39) S237T probably benign Het
Sanbr A C 11: 23,531,642 (GRCm39) M661R possibly damaging Het
Slc9a2 G A 1: 40,721,061 (GRCm39) V10M probably benign Het
Sytl2 T C 7: 90,024,800 (GRCm39) S263P probably benign Het
Taf7l2 A T 10: 115,948,931 (GRCm39) D198E probably benign Het
Trrap G A 5: 144,777,330 (GRCm39) V3043M probably damaging Het
Tshz3 C T 7: 36,470,492 (GRCm39) T827I possibly damaging Het
Ttll1 T C 15: 83,384,226 (GRCm39) T134A possibly damaging Het
Vmn1r196 G T 13: 22,477,920 (GRCm39) M186I probably damaging Het
Vrk2 C T 11: 26,433,157 (GRCm39) probably null Het
Zfp59 T A 7: 27,554,483 (GRCm39) V645E probably benign Het
Other mutations in Or4a77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00938:Or4a77 APN 2 89,487,420 (GRCm39) missense probably damaging 0.98
IGL01608:Or4a77 APN 2 89,486,835 (GRCm39) utr 3 prime probably benign
IGL01913:Or4a77 APN 2 89,487,684 (GRCm39) missense probably benign 0.01
IGL02458:Or4a77 APN 2 89,487,692 (GRCm39) missense probably damaging 1.00
R0102:Or4a77 UTSW 2 89,486,999 (GRCm39) missense probably benign 0.10
R0621:Or4a77 UTSW 2 89,487,459 (GRCm39) nonsense probably null
R0826:Or4a77 UTSW 2 89,487,181 (GRCm39) missense possibly damaging 0.49
R5460:Or4a77 UTSW 2 89,487,414 (GRCm39) missense probably damaging 1.00
R5720:Or4a77 UTSW 2 89,487,299 (GRCm39) missense probably benign 0.20
R6044:Or4a77 UTSW 2 89,487,516 (GRCm39) missense probably damaging 1.00
R6965:Or4a77 UTSW 2 89,487,009 (GRCm39) missense probably damaging 1.00
R7069:Or4a77 UTSW 2 89,486,910 (GRCm39) missense probably benign 0.00
R7305:Or4a77 UTSW 2 89,486,846 (GRCm39) missense probably benign
R8058:Or4a77 UTSW 2 89,487,671 (GRCm39) missense probably benign 0.01
R9487:Or4a77 UTSW 2 89,487,731 (GRCm39) missense probably damaging 0.99
Z1177:Or4a77 UTSW 2 89,487,278 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACATGTAAAACACTGTGGTC -3'
(R):5'- ATGGAGCAATGTCTATAGTGGTC -3'

Sequencing Primer
(F):5'- TGTAAAACACTGTGGTCAAATAGAC -3'
(R):5'- GCAATGTCTATAGTGGTCTTTATCC -3'
Posted On 2022-08-09