Incidental Mutation 'R9595:Mall'
ID 723203
Institutional Source Beutler Lab
Gene Symbol Mall
Ensembl Gene ENSMUSG00000027377
Gene Name mal, T cell differentiation protein-like
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R9595 (G1)
Quality Score 116.008
Status Not validated
Chromosome 2
Chromosomal Location 127546310-127571817 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 127571751 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 12 (Y12*)
Ref Sequence ENSEMBL: ENSMUSP00000028856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028856]
AlphaFold Q91X49
Predicted Effect probably null
Transcript: ENSMUST00000028856
AA Change: Y12*
SMART Domains Protein: ENSMUSP00000028856
Gene: ENSMUSG00000027377
AA Change: Y12*

DomainStartEndE-ValueType
Pfam:MARVEL 24 150 1.2e-12 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T C 13: 77,464,566 (GRCm39) M921T probably benign Het
Ankrd33 T C 15: 101,013,785 (GRCm39) probably null Het
Azin2 A G 4: 128,853,617 (GRCm39) V80A probably benign Het
Capza3 A T 6: 139,987,712 (GRCm39) I104F probably benign Het
Cd177 A G 7: 24,451,762 (GRCm39) L418P probably damaging Het
Cd86 A T 16: 36,441,275 (GRCm39) V64D probably damaging Het
Cfap65 A G 1: 74,946,537 (GRCm39) S1352P probably damaging Het
Chst10 C A 1: 38,913,029 (GRCm39) probably null Het
Cyp2j13 G T 4: 95,933,797 (GRCm39) C362* probably null Het
Ddn T C 15: 98,705,577 (GRCm39) T40A possibly damaging Het
Dennd2b C T 7: 109,155,973 (GRCm39) R259Q probably damaging Het
Fam47e G C 5: 92,726,395 (GRCm39) R111P probably benign Het
Fermt3 C T 19: 6,979,619 (GRCm39) V505M probably damaging Het
Flnc A G 6: 29,433,720 (GRCm39) H88R probably benign Het
Glyat A G 19: 12,623,728 (GRCm39) D48G probably damaging Het
Hdac5 A G 11: 102,096,129 (GRCm39) V348A probably benign Het
Ighv2-3 T C 12: 113,575,084 (GRCm39) K24E probably benign Het
Iglv1 A G 16: 18,903,948 (GRCm39) V57A possibly damaging Het
Il16 G T 7: 83,322,273 (GRCm39) Y347* probably null Het
Il20rb G A 9: 100,368,311 (GRCm39) T24M possibly damaging Het
Itgae A G 11: 73,016,182 (GRCm39) D797G probably damaging Het
Lrrc37a T A 11: 103,392,552 (GRCm39) T958S probably benign Het
N4bp3 C T 11: 51,536,932 (GRCm39) R47Q probably damaging Het
Nacad T C 11: 6,551,790 (GRCm39) D467G probably damaging Het
Or12k8 C A 2: 36,975,204 (GRCm39) K185N possibly damaging Het
Or13a18 T C 7: 140,190,939 (GRCm39) S279P probably damaging Het
Or1af1 T A 2: 37,110,281 (GRCm39) I260N probably damaging Het
Or4f61 T C 2: 111,922,375 (GRCm39) T224A probably damaging Het
Or7a40 G A 16: 16,491,470 (GRCm39) A125V probably damaging Het
Or7e177 A G 9: 20,211,661 (GRCm39) N56S probably damaging Het
Osbpl8 A G 10: 111,108,909 (GRCm39) E397G probably damaging Het
Pcmt1 A T 10: 7,524,817 (GRCm39) I111K possibly damaging Het
Pcnx1 T A 12: 81,965,688 (GRCm39) H90Q Het
Pde4dip C T 3: 97,602,207 (GRCm39) probably null Het
Peli2 T A 14: 48,493,846 (GRCm39) V356D probably damaging Het
Phyhipl G T 10: 70,395,512 (GRCm39) C231* probably null Het
Pirb A T 7: 3,722,406 (GRCm39) S146T possibly damaging Het
Rac1 G A 5: 143,513,643 (GRCm39) probably benign Het
Sh3glb2 C T 2: 30,236,672 (GRCm39) R230Q probably damaging Het
Slc38a8 C A 8: 120,209,403 (GRCm39) C390F probably benign Het
Slc39a8 G T 3: 135,592,688 (GRCm39) L454F possibly damaging Het
Slit1 A C 19: 41,637,851 (GRCm39) I314S probably damaging Het
Son T G 16: 91,454,241 (GRCm39) M996R possibly damaging Het
Sp4 A G 12: 118,262,690 (GRCm39) V452A possibly damaging Het
Tmf1 C T 6: 97,135,457 (GRCm39) D940N probably damaging Het
Tns3 G A 11: 8,401,142 (GRCm39) T1052M possibly damaging Het
Trim33 C T 3: 103,259,350 (GRCm39) P1013L probably damaging Het
Vmn1r175 A T 7: 23,508,508 (GRCm39) S40T probably damaging Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Wdr49 C T 3: 75,265,747 (GRCm39) C233Y probably damaging Het
Wrn T C 8: 33,758,961 (GRCm39) E999G probably benign Het
Yju2b C T 8: 84,988,400 (GRCm39) V76I probably damaging Het
Zfp142 A T 1: 74,611,462 (GRCm39) C778S probably damaging Het
Other mutations in Mall
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01690:Mall APN 2 127,571,699 (GRCm39) missense probably benign 0.03
R3811:Mall UTSW 2 127,550,774 (GRCm39) missense probably damaging 0.97
R7084:Mall UTSW 2 127,550,793 (GRCm39) missense probably benign
R8074:Mall UTSW 2 127,571,785 (GRCm39) start codon destroyed probably null 1.00
Predicted Primers PCR Primer
(F):5'- TTGCTCTAGAGGAACCCAGC -3'
(R):5'- CTAGAAAGACCCTCTGCGAG -3'

Sequencing Primer
(F):5'- AAGTTAACTGCCAGCGAG -3'
(R):5'- TCTCCTGGCTAGCACAGTG -3'
Posted On 2022-08-09