Incidental Mutation 'R9750:Ccl21a'
ID 732461
Institutional Source Beutler Lab
Gene Symbol Ccl21a
Ensembl Gene ENSMUSG00000094686
Gene Name C-C motif chemokine ligand 21 (serine)
Synonyms ALP, CKb9, Scya21, Scya21b, Tca4, Gm1987, 6CKBAC2, 6Ckine, Exodus-2, SLC
MMRRC Submission
Accession Numbers
Essential gene? Not available question?
Stock # R9750 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 42772860-42773991 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 42773875 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 15 (A15V)
Ref Sequence ENSEMBL: ENSMUSP00000092732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068158] [ENSMUST00000095114] [ENSMUST00000107984]
AlphaFold P84444
Predicted Effect probably benign
Transcript: ENSMUST00000068158
SMART Domains Protein: ENSMUSP00000068585
Gene: ENSMUSG00000054885

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 72 88 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000095114
AA Change: A15V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000092732
Gene: ENSMUSG00000094686
AA Change: A15V

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
SCY 28 90 3.04e-18 SMART
low complexity region 108 121 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107984
SMART Domains Protein: ENSMUSP00000103618
Gene: ENSMUSG00000054885

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 72 88 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.2%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired negative T cell selection with small thymus medulla, decreased thymic B cells and autoimmune dacryoadenitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts2 G T 11: 50,494,333 (GRCm39) V136L probably benign Het
Adamtsl3 G T 7: 82,244,589 (GRCm39) L1348F probably benign Het
Amotl1 T A 9: 14,504,102 (GRCm39) T369S probably benign Het
Anapc2 T G 2: 25,174,982 (GRCm39) V700G possibly damaging Het
Aox3 C T 1: 58,215,648 (GRCm39) Q1027* probably null Het
Ap5m1 A G 14: 49,317,756 (GRCm39) T338A probably benign Het
Carf T A 1: 60,171,158 (GRCm39) Y240* probably null Het
Dcst1 A T 3: 89,261,462 (GRCm39) I429N probably damaging Het
Esco1 A G 18: 10,594,510 (GRCm39) S259P probably benign Het
Esp15 A G 17: 39,955,603 (GRCm39) M57V probably benign Het
Fat3 A G 9: 15,915,157 (GRCm39) I1597T probably benign Het
Fbxo38 T C 18: 62,674,061 (GRCm39) S7G probably benign Het
Gm11562 G A 11: 99,510,856 (GRCm39) P115S unknown Het
Hectd4 A T 5: 121,448,744 (GRCm39) Y364F probably benign Het
Kansl1l G C 1: 66,817,150 (GRCm39) I403M probably benign Het
Kmt2a T C 9: 44,747,499 (GRCm39) H1505R unknown Het
Krt79 T G 15: 101,839,196 (GRCm39) E424D probably benign Het
Lpgat1 T A 1: 191,510,587 (GRCm39) F391I probably benign Het
Ltbr G A 6: 125,284,348 (GRCm39) R365W probably damaging Het
Mon1a T A 9: 107,778,778 (GRCm39) V334E probably damaging Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Nup210l A T 3: 90,117,659 (GRCm39) probably null Het
Obscn G A 11: 59,024,682 (GRCm39) R453W probably benign Het
Or1d2 A G 11: 74,255,858 (GRCm39) D121G possibly damaging Het
Pdzd8 A G 19: 59,289,684 (GRCm39) V572A probably benign Het
Pgr T C 9: 8,901,918 (GRCm39) S484P possibly damaging Het
Pygl G T 12: 70,245,303 (GRCm39) S473R possibly damaging Het
Samd1 T C 8: 84,725,989 (GRCm39) V410A probably damaging Het
Serpina3j T G 12: 104,280,942 (GRCm39) H38Q probably benign Het
Shprh A G 10: 11,040,204 (GRCm39) Y559C probably damaging Het
Skint5 T A 4: 113,727,866 (GRCm39) D426V unknown Het
Slc25a21 T C 12: 56,785,382 (GRCm39) K158R probably benign Het
Smc1b A T 15: 85,016,106 (GRCm39) N11K probably damaging Het
St18 T C 1: 6,873,216 (GRCm39) V317A probably benign Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Tcap A G 11: 98,275,228 (GRCm39) T121A probably benign Het
Tgs1 C A 4: 3,585,869 (GRCm39) Q249K probably damaging Het
Tiam1 A T 16: 89,695,394 (GRCm39) L21Q probably damaging Het
Tmem131l G A 3: 83,831,358 (GRCm39) A858V probably damaging Het
Trpm3 G A 19: 22,903,495 (GRCm39) R927H probably benign Het
Wdfy3 T A 5: 102,077,960 (GRCm39) H870L probably benign Het
Zfp518a T A 19: 40,903,889 (GRCm39) C1273S possibly damaging Het
Zfp960 A T 17: 17,307,898 (GRCm39) H204L probably damaging Het
Other mutations in Ccl21a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7422:Ccl21a UTSW 4 42,773,906 (GRCm39) missense probably benign
R8398:Ccl21a UTSW 4 42,773,412 (GRCm39) missense probably benign 0.00
R9090:Ccl21a UTSW 4 42,773,486 (GRCm39) missense probably damaging 0.99
R9271:Ccl21a UTSW 4 42,773,486 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCTTCCTATAGCCTCGGAC -3'
(R):5'- TCTGATCCAACTCACAGGAAAAGG -3'

Sequencing Primer
(F):5'- CTATAGCCTCGGACAATACTGTAGG -3'
(R):5'- CCAACTCACAGGAAAAGGAGGGG -3'
Posted On 2022-11-14