Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01459:Vmn1r197'

87923

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r197

Ensembl Gene

ENSMUSG00000069294

Gene Name

vomeronasal 1 receptor 197

Synonyms

V1rh21

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL01459

Quality Score

Status

Chromosome

Chromosomal Location

22512081-22512977 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22512241 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 54 (I54T)

Ref Sequence

ENSEMBL: ENSMUSP00000154632 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091734] [ENSMUST00000226225] [ENSMUST00000227017]

AlphaFold

Q8R265

Predicted Effect

probably benign
Transcript: ENSMUST00000091734
AA Change: I54T

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000089328
Gene: ENSMUSG00000069294
AA Change: I54T

Domain	Start	End	E-Value	Type
transmembrane domain	10	29	N/A	INTRINSIC
Pfam:V1R	31	297	1.4e-40	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226225
AA Change: I54T

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

Predicted Effect

probably benign
Transcript: ENSMUST00000227017
AA Change: I54T

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp2a2	A	G	5: 122,607,715 (GRCm39)	S265P	probably benign	Het
Brwd1	A	G	16: 95,848,620 (GRCm39)	F520L	probably damaging	Het
Cdh5	A	T	8: 104,864,449 (GRCm39)	D470V	probably damaging	Het
Cdr2l	A	G	11: 115,281,378 (GRCm39)	R41G	probably damaging	Het
Csrnp1	C	T	9: 119,802,024 (GRCm39)	C345Y	probably damaging	Het
Dscaml1	T	A	9: 45,653,981 (GRCm39)	Y1419*	probably null	Het
Entpd3	T	C	9: 120,391,007 (GRCm39)	S420P	probably damaging	Het
Epb41	A	G	4: 131,691,439 (GRCm39)		probably benign	Het
Erg	A	G	16: 95,162,141 (GRCm39)	S322P	probably damaging	Het
Fndc3b	T	A	3: 27,515,889 (GRCm39)	H639L	probably benign	Het
Grwd1	C	T	7: 45,479,834 (GRCm39)		probably null	Het
Kbtbd8	A	G	6: 95,099,789 (GRCm39)	N356D	probably benign	Het
Kif15	A	G	9: 122,804,820 (GRCm39)	E189G	probably damaging	Het
Kif2b	T	C	11: 91,467,849 (GRCm39)	K145E	possibly damaging	Het
Kif5c	A	G	2: 49,625,569 (GRCm39)	D613G	probably benign	Het
Lipe	T	G	7: 25,082,967 (GRCm39)	Q457P	probably damaging	Het
Lrp1b	A	T	2: 40,750,726 (GRCm39)	I2946N	probably damaging	Het
Mtf2	C	T	5: 108,228,809 (GRCm39)	P42S	probably damaging	Het
Neb	A	G	2: 52,066,804 (GRCm39)	S5886P	probably damaging	Het
Nmu	A	G	5: 76,506,196 (GRCm39)		probably null	Het
Nup153	T	C	13: 46,866,402 (GRCm39)	E214G	possibly damaging	Het
Or14c44	A	C	7: 86,061,759 (GRCm39)	N104T	probably damaging	Het
Or6c66b	G	A	10: 129,376,410 (GRCm39)	M1I	probably null	Het
Paqr3	T	C	5: 97,243,796 (GRCm39)	D306G	probably benign	Het
Plxna2	A	G	1: 194,446,878 (GRCm39)	D796G	probably benign	Het
Prkra	A	G	2: 76,460,780 (GRCm39)	L306S	probably damaging	Het
Psg20	T	A	7: 18,416,638 (GRCm39)	E159D	probably damaging	Het
Ptchd3	G	T	11: 121,721,246 (GRCm39)	V40L	probably benign	Het
Rfx5	T	C	3: 94,865,086 (GRCm39)		probably benign	Het
Rimbp2	A	G	5: 128,865,275 (GRCm39)		probably null	Het
Slc22a4	C	A	11: 53,877,303 (GRCm39)		probably null	Het
Tars1	A	G	15: 11,391,940 (GRCm39)	V265A	possibly damaging	Het
Tatdn2	T	A	6: 113,686,992 (GRCm39)		probably null	Het
Tenm4	C	T	7: 96,378,592 (GRCm39)	P399L	probably damaging	Het
Tmem135	A	T	7: 88,800,646 (GRCm39)	D325E	probably damaging	Het
Tmprss7	A	T	16: 45,483,706 (GRCm39)	I556N	probably benign	Het
Tom1l2	C	T	11: 60,171,095 (GRCm39)	G23S	probably damaging	Het
Ubr2	A	G	17: 47,241,435 (GRCm39)		probably benign	Het
Vmn2r116	T	C	17: 23,603,903 (GRCm39)	C43R	probably damaging	Het
Vps33a	A	G	5: 123,673,371 (GRCm39)	L405P	probably benign	Het
Zfp473	C	T	7: 44,388,987 (GRCm39)	D45N	probably damaging	Het

Other mutations in Vmn1r197

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01944:Vmn1r197	APN	13	22,512,508 (GRCm39)	missense	possibly damaging	0.77
IGL02317:Vmn1r197	APN	13	22,512,073 (GRCm39)	utr 5 prime	probably benign
IGL02487:Vmn1r197	APN	13	22,512,792 (GRCm39)	missense	probably damaging	1.00
R0443:Vmn1r197	UTSW	13	22,512,241 (GRCm39)	missense	possibly damaging	0.90
R1511:Vmn1r197	UTSW	13	22,512,823 (GRCm39)	missense	possibly damaging	0.92
R1542:Vmn1r197	UTSW	13	22,512,520 (GRCm39)	missense	probably benign	0.01
R1617:Vmn1r197	UTSW	13	22,512,498 (GRCm39)	missense	possibly damaging	0.55
R1739:Vmn1r197	UTSW	13	22,512,541 (GRCm39)	missense	possibly damaging	0.80
R3739:Vmn1r197	UTSW	13	22,512,746 (GRCm39)	nonsense	probably null
R4761:Vmn1r197	UTSW	13	22,512,174 (GRCm39)	missense	probably benign	0.00
R5335:Vmn1r197	UTSW	13	22,512,361 (GRCm39)	missense	probably damaging	1.00
R6168:Vmn1r197	UTSW	13	22,512,678 (GRCm39)	missense	possibly damaging	0.65
R8056:Vmn1r197	UTSW	13	22,512,388 (GRCm39)	missense	probably damaging	1.00
R9282:Vmn1r197	UTSW	13	22,512,608 (GRCm39)	missense	possibly damaging	0.92
Z1177:Vmn1r197	UTSW	13	22,512,099 (GRCm39)	nonsense	probably null

Posted On

2013-11-18