Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01484:Ifit1'

88863

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifit1

Ensembl Gene

ENSMUSG00000034459

Gene Name

interferon-induced protein with tetratricopeptide repeats 1

Synonyms

Ifi56, ISG56

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL01484

Quality Score

Status

Chromosome

Chromosomal Location

34618289-34627409 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 34626243 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 460 (N460D)

Ref Sequence

ENSEMBL: ENSMUSP00000099888 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102824]

AlphaFold

Q64282

Predicted Effect

probably damaging
Transcript: ENSMUST00000102824
AA Change: N460D

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000099888
Gene: ENSMUSG00000034459
AA Change: N460D

Domain	Start	End	E-Value	Type
TPR	52	85	4.8e1	SMART
TPR	92	125	6.92e1	SMART
TPR	138	171	1.2e1	SMART
low complexity region	210	221	N/A	INTRINSIC
low complexity region	223	234	N/A	INTRINSIC
TPR	242	275	4.93e1	SMART
TPR	329	362	3.89e1	SMART
TPR	426	459	1.45e-1	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered response to vesicular stomatitis virus (VSV) infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd36	A	G	11: 5,579,006 (GRCm39)	H90R	possibly damaging	Het
Arsj	A	G	3: 126,158,685 (GRCm39)	D88G	probably damaging	Het
Clca4b	C	T	3: 144,633,996 (GRCm39)	V140I	probably benign	Het
Dagla	A	C	19: 10,225,884 (GRCm39)	L760R	possibly damaging	Het
Dnah1	T	C	14: 31,021,897 (GRCm39)	E1202G	probably damaging	Het
Hdac9	T	C	12: 34,487,164 (GRCm39)	H100R	probably damaging	Het
Hhip	T	C	8: 80,723,412 (GRCm39)	H414R	probably damaging	Het
Hk2	G	A	6: 82,713,711 (GRCm39)	T457M	probably damaging	Het
Iapp	A	G	6: 142,249,165 (GRCm39)	T73A	possibly damaging	Het
Itpa	T	C	2: 130,514,019 (GRCm39)	F77L	probably benign	Het
Knop1	T	C	7: 118,452,032 (GRCm39)	D229G	probably damaging	Het
Lrrc32	T	C	7: 98,143,442 (GRCm39)	I5T	probably damaging	Het
Myo7a	C	T	7: 97,734,629 (GRCm39)	V622M	probably damaging	Het
N4bp1	T	C	8: 87,571,400 (GRCm39)	E866G	probably damaging	Het
Or2t48	A	T	11: 58,420,222 (GRCm39)	W197R	probably benign	Het
Palmd	G	A	3: 116,746,794 (GRCm39)		probably benign	Het
Pcbp4	A	G	9: 106,337,848 (GRCm39)		probably null	Het
Pigf	T	C	17: 87,316,308 (GRCm39)	I157V	probably benign	Het
Pot1b	G	A	17: 56,002,160 (GRCm39)	T138M	possibly damaging	Het
Prl7a2	T	A	13: 27,843,191 (GRCm39)	D204V	probably damaging	Het
Rfc3	A	T	5: 151,566,401 (GRCm39)	D349E	probably benign	Het
Sarm1	A	T	11: 78,381,839 (GRCm39)	C215S	probably damaging	Het
Serpine1	T	C	5: 137,092,326 (GRCm39)		probably benign	Het
Strip1	A	G	3: 107,520,575 (GRCm39)	V825A	probably damaging	Het
Stx12	A	G	4: 132,611,673 (GRCm39)	S2P	probably damaging	Het
Sycp1	A	C	3: 102,823,183 (GRCm39)	S311R	probably benign	Het
Tfpi	A	T	2: 84,275,169 (GRCm39)	C139*	probably null	Het
Tmc5	T	A	7: 118,256,010 (GRCm39)	I695N	probably damaging	Het
Tmem169	T	C	1: 72,340,263 (GRCm39)	V231A	probably damaging	Het
Ttbk2	T	G	2: 120,570,314 (GRCm39)	S1211R	possibly damaging	Het
Ubr3	C	T	2: 69,851,888 (GRCm39)	R1855*	probably null	Het
Urb1	A	T	16: 90,574,448 (GRCm39)	S878T	probably benign	Het
Vmn1r174	T	A	7: 23,453,749 (GRCm39)	Y138*	probably null	Het
Zfp282	A	G	6: 47,867,054 (GRCm39)	N214D	possibly damaging	Het

Other mutations in Ifit1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Ifit1	APN	19	34,625,533 (GRCm39)	missense	possibly damaging	0.73
IGL01505:Ifit1	APN	19	34,625,854 (GRCm39)	missense	probably benign	0.38
IGL02663:Ifit1	APN	19	34,618,380 (GRCm39)	utr 5 prime	probably benign
IGL03063:Ifit1	APN	19	34,625,404 (GRCm39)	missense	possibly damaging	0.71
R0655:Ifit1	UTSW	19	34,625,047 (GRCm39)	missense	probably damaging	1.00
R1524:Ifit1	UTSW	19	34,625,032 (GRCm39)	missense	probably damaging	0.97
R1859:Ifit1	UTSW	19	34,624,944 (GRCm39)	missense	probably benign	0.00
R3805:Ifit1	UTSW	19	34,625,556 (GRCm39)	missense	probably damaging	0.99
R4514:Ifit1	UTSW	19	34,625,913 (GRCm39)	nonsense	probably null
R4714:Ifit1	UTSW	19	34,625,563 (GRCm39)	missense	probably damaging	0.99
R5310:Ifit1	UTSW	19	34,626,204 (GRCm39)	missense	probably benign
R5620:Ifit1	UTSW	19	34,625,238 (GRCm39)	missense	probably damaging	1.00
R5787:Ifit1	UTSW	19	34,624,975 (GRCm39)	missense	probably benign	0.29
R5964:Ifit1	UTSW	19	34,625,869 (GRCm39)	missense	possibly damaging	0.76
R8230:Ifit1	UTSW	19	34,625,068 (GRCm39)	missense	probably benign	0.00
R8249:Ifit1	UTSW	19	34,618,389 (GRCm39)	critical splice donor site	probably null
R8713:Ifit1	UTSW	19	34,625,038 (GRCm39)	missense	probably benign	0.01
R9054:Ifit1	UTSW	19	34,625,887 (GRCm39)	missense	possibly damaging	0.91
R9227:Ifit1	UTSW	19	34,625,236 (GRCm39)	missense	possibly damaging	0.86
R9230:Ifit1	UTSW	19	34,625,236 (GRCm39)	missense	possibly damaging	0.86
R9723:Ifit1	UTSW	19	34,626,257 (GRCm39)	makesense	probably null

Posted On

2013-11-18