Incidental Mutation 'IGL01528:Dusp22'
ID 89647
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp22
Ensembl Gene ENSMUSG00000069255
Gene Name dual specificity phosphatase 22
Synonyms 1110028K04Rik, JKAP, JSP1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01528
Quality Score
Status
Chromosome 13
Chromosomal Location 30844042-30895215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 30889611 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 64 (T64I)
Ref Sequence ENSEMBL: ENSMUSP00000093603 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091672] [ENSMUST00000095914] [ENSMUST00000110310] [ENSMUST00000221725]
AlphaFold Q99N11
Predicted Effect probably benign
Transcript: ENSMUST00000091672
AA Change: T64I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000089260
Gene: ENSMUSG00000069255
AA Change: T64I

DomainStartEndE-ValueType
DSPc 4 141 2.62e-48 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000095914
AA Change: T64I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000093603
Gene: ENSMUSG00000069255
AA Change: T64I

DomainStartEndE-ValueType
DSPc 4 141 2.62e-48 SMART
low complexity region 180 194 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110310
AA Change: T64I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000105939
Gene: ENSMUSG00000069255
AA Change: T64I

DomainStartEndE-ValueType
Pfam:DSPc 12 89 2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220748
Predicted Effect silent
Transcript: ENSMUST00000221725
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 T A 9: 21,451,190 (GRCm39) probably benign Het
Cdc45 A G 16: 18,630,311 (GRCm39) F2S probably damaging Het
Cdon A G 9: 35,381,403 (GRCm39) R598G possibly damaging Het
Cemip2 T C 19: 21,812,909 (GRCm39) V1038A possibly damaging Het
Gfer T A 17: 24,914,903 (GRCm39) T47S probably benign Het
Gfra2 T C 14: 71,203,738 (GRCm39) S296P possibly damaging Het
Gjb2 G A 14: 57,338,125 (GRCm39) L28F probably damaging Het
Gm17782 A G 17: 36,472,682 (GRCm39) probably benign Het
Gm2832 T C 14: 41,003,670 (GRCm39) V167A unknown Het
Gpr155 A G 2: 73,192,767 (GRCm39) probably null Het
Gpr45 A G 1: 43,072,383 (GRCm39) H342R probably benign Het
Gsdmd A T 15: 75,735,354 (GRCm39) T33S possibly damaging Het
Hal T A 10: 93,333,455 (GRCm39) L341Q probably damaging Het
Igfbp7 T G 5: 77,499,179 (GRCm39) D273A probably damaging Het
Kdm2a T C 19: 4,393,083 (GRCm39) D424G probably benign Het
Kif13a C T 13: 47,018,313 (GRCm39) probably benign Het
Krt35 A T 11: 99,985,420 (GRCm39) L207Q probably damaging Het
Lrp1b A T 2: 40,809,194 (GRCm39) D2572E probably damaging Het
Lrp2 A G 2: 69,322,804 (GRCm39) V1848A probably damaging Het
Myo9a T C 9: 59,686,957 (GRCm39) Y21H probably damaging Het
Ncan G T 8: 70,562,731 (GRCm39) A509E probably benign Het
Or2q1 T C 6: 42,795,208 (GRCm39) S268P probably damaging Het
Pde11a G A 2: 76,025,300 (GRCm39) probably benign Het
Phf19 G T 2: 34,787,119 (GRCm39) D448E probably damaging Het
Ptprj A T 2: 90,282,488 (GRCm39) V799D probably damaging Het
Rpgrip1 T A 14: 52,349,634 (GRCm39) Y7* probably null Het
Sema3c A G 5: 17,919,413 (GRCm39) H483R probably benign Het
Slc4a11 A G 2: 130,527,328 (GRCm39) probably benign Het
St3gal1 C A 15: 66,984,466 (GRCm39) R103L probably benign Het
Tet2 A T 3: 133,186,059 (GRCm39) V1126E possibly damaging Het
Tmem117 A T 15: 94,992,545 (GRCm39) I402L probably benign Het
Ttc28 T A 5: 111,249,826 (GRCm39) probably benign Het
Ttn A T 2: 76,702,182 (GRCm39) probably benign Het
Vmn1r7 T A 6: 57,001,532 (GRCm39) M243L probably benign Het
Wnt1 G T 15: 98,689,714 (GRCm39) W167L probably damaging Het
Zfp553 G T 7: 126,835,387 (GRCm39) S314I probably damaging Het
Zranb2 T C 3: 157,250,602 (GRCm39) probably benign Het
Other mutations in Dusp22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Dusp22 APN 13 30,880,235 (GRCm39) missense probably damaging 1.00
IGL01835:Dusp22 APN 13 30,892,666 (GRCm39) splice site probably null
IGL02563:Dusp22 APN 13 30,889,628 (GRCm39) missense possibly damaging 0.91
paused UTSW 13 30,852,774 (GRCm39) splice site probably null
R0310:Dusp22 UTSW 13 30,889,641 (GRCm39) missense probably damaging 0.96
R1491:Dusp22 UTSW 13 30,892,798 (GRCm39) missense probably benign
R4211:Dusp22 UTSW 13 30,892,726 (GRCm39) missense probably benign 0.32
R4884:Dusp22 UTSW 13 30,852,813 (GRCm39) missense probably benign 0.21
R5877:Dusp22 UTSW 13 30,891,944 (GRCm39) missense probably damaging 1.00
R7842:Dusp22 UTSW 13 30,852,774 (GRCm39) splice site probably null
R7859:Dusp22 UTSW 13 30,892,737 (GRCm39) missense probably benign 0.01
R8314:Dusp22 UTSW 13 30,892,914 (GRCm39) unclassified probably benign
Posted On 2013-12-03