Incidental Mutation 'IGL01734:Dusp22'
ID 105616
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp22
Ensembl Gene ENSMUSG00000069255
Gene Name dual specificity phosphatase 22
Synonyms 1110028K04Rik, JKAP, JSP1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01734
Quality Score
Status
Chromosome 13
Chromosomal Location 30844042-30895215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 30880235 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 52 (C52F)
Ref Sequence ENSEMBL: ENSMUSP00000105939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091672] [ENSMUST00000095914] [ENSMUST00000110310] [ENSMUST00000221725]
AlphaFold Q99N11
Predicted Effect probably damaging
Transcript: ENSMUST00000091672
AA Change: C52F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000089260
Gene: ENSMUSG00000069255
AA Change: C52F

DomainStartEndE-ValueType
DSPc 4 141 2.62e-48 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000095914
AA Change: C52F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000093603
Gene: ENSMUSG00000069255
AA Change: C52F

DomainStartEndE-ValueType
DSPc 4 141 2.62e-48 SMART
low complexity region 180 194 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110310
AA Change: C52F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000105939
Gene: ENSMUSG00000069255
AA Change: C52F

DomainStartEndE-ValueType
Pfam:DSPc 12 89 2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220748
Predicted Effect probably benign
Transcript: ENSMUST00000221725
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932442E05Rik T A 10: 118,697,371 (GRCm39) W210R possibly damaging Het
Aknad1 T C 3: 108,659,217 (GRCm39) M77T probably benign Het
Aox1 A T 1: 58,393,469 (GRCm39) I1210F possibly damaging Het
Brd8 A T 18: 34,747,858 (GRCm39) probably benign Het
Cdh23 T C 10: 60,139,292 (GRCm39) D3307G probably benign Het
Chsy1 T C 7: 65,821,058 (GRCm39) I431T probably damaging Het
Cobl A G 11: 12,204,980 (GRCm39) probably benign Het
Col28a1 T C 6: 8,158,134 (GRCm39) D308G probably damaging Het
Csmd3 A G 15: 48,048,700 (GRCm39) Y568H probably damaging Het
Dmrt3 T C 19: 25,599,947 (GRCm39) I264T probably damaging Het
Fbxw22 A C 9: 109,212,993 (GRCm39) M318R probably damaging Het
Ffar4 C T 19: 38,102,295 (GRCm39) T310M probably damaging Het
Fn1 A G 1: 71,658,644 (GRCm39) V1138A probably damaging Het
Glt6d1 T A 2: 25,684,505 (GRCm39) Y167F probably benign Het
Hydin T A 8: 111,217,421 (GRCm39) Y1436* probably null Het
Il12a G A 3: 68,598,888 (GRCm39) C2Y possibly damaging Het
Inpp5a T C 7: 139,034,006 (GRCm39) Y38H possibly damaging Het
Jmy A C 13: 93,596,159 (GRCm39) L490R probably damaging Het
Kif26a T A 12: 112,143,262 (GRCm39) L1172H probably benign Het
Kmo A T 1: 175,482,668 (GRCm39) M331L probably benign Het
Lonp1 G A 17: 56,923,026 (GRCm39) T627M probably damaging Het
Lrrc41 T C 4: 115,950,331 (GRCm39) probably null Het
Mast4 A T 13: 102,874,123 (GRCm39) S1556R probably damaging Het
Mmel1 A G 4: 154,976,408 (GRCm39) N490S probably benign Het
Mpped2 A G 2: 106,614,158 (GRCm39) D164G probably damaging Het
Nap1l1 A G 10: 111,328,760 (GRCm39) T230A probably benign Het
Nrap C A 19: 56,338,741 (GRCm39) A913S probably damaging Het
Nudt16 G T 9: 105,008,707 (GRCm39) Q65K probably benign Het
Or1e23 C A 11: 73,407,462 (GRCm39) A188S probably benign Het
Or5ac17 T G 16: 59,036,792 (GRCm39) L61F probably benign Het
Or5ac19 T A 16: 59,089,213 (GRCm39) K272N probably benign Het
Or5al5 T A 2: 85,962,012 (GRCm39) probably benign Het
Or6c76b T A 10: 129,692,671 (GRCm39) C95S probably benign Het
Parp14 A G 16: 35,678,970 (GRCm39) F333L probably benign Het
Pi4ka G T 16: 17,115,124 (GRCm39) Q1422K probably benign Het
Polr3c T C 3: 96,620,836 (GRCm39) E494G probably damaging Het
Prss42 C A 9: 110,627,411 (GRCm39) P49Q probably benign Het
Ptpra C T 2: 130,385,997 (GRCm39) T568I probably damaging Het
Ring1 T C 17: 34,242,294 (GRCm39) D71G probably damaging Het
Siae T A 9: 37,542,782 (GRCm39) S193T probably damaging Het
Slf2 T C 19: 44,961,706 (GRCm39) probably null Het
Spinkl T A 18: 44,307,639 (GRCm39) K7N possibly damaging Het
Tbk1 G A 10: 121,407,888 (GRCm39) R82* probably null Het
Tcf12 T C 9: 71,829,930 (GRCm39) probably null Het
Tcl1b5 G A 12: 105,145,214 (GRCm39) M59I probably benign Het
Thumpd3 C A 6: 113,043,806 (GRCm39) T407K probably damaging Het
Timm29 T C 9: 21,505,031 (GRCm39) V233A probably damaging Het
Tns3 A G 11: 8,469,192 (GRCm39) probably benign Het
Ubash3b T C 9: 40,937,543 (GRCm39) probably benign Het
Ugdh G T 5: 65,580,031 (GRCm39) T253K probably benign Het
Zfp143 T A 7: 109,671,416 (GRCm39) probably benign Het
Zfp738 A G 13: 67,831,563 (GRCm39) probably benign Het
Other mutations in Dusp22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01528:Dusp22 APN 13 30,889,611 (GRCm39) missense probably benign 0.00
IGL01835:Dusp22 APN 13 30,892,666 (GRCm39) splice site probably null
IGL02563:Dusp22 APN 13 30,889,628 (GRCm39) missense possibly damaging 0.91
paused UTSW 13 30,852,774 (GRCm39) splice site probably null
R0310:Dusp22 UTSW 13 30,889,641 (GRCm39) missense probably damaging 0.96
R1491:Dusp22 UTSW 13 30,892,798 (GRCm39) missense probably benign
R4211:Dusp22 UTSW 13 30,892,726 (GRCm39) missense probably benign 0.32
R4884:Dusp22 UTSW 13 30,852,813 (GRCm39) missense probably benign 0.21
R5877:Dusp22 UTSW 13 30,891,944 (GRCm39) missense probably damaging 1.00
R7842:Dusp22 UTSW 13 30,852,774 (GRCm39) splice site probably null
R7859:Dusp22 UTSW 13 30,892,737 (GRCm39) missense probably benign 0.01
R8314:Dusp22 UTSW 13 30,892,914 (GRCm39) unclassified probably benign
Posted On 2014-01-21