Incidental Mutation 'IGL01557:Zfp648'
ID90761
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp648
Ensembl Gene ENSMUSG00000066797
Gene Namezinc finger protein 648
SynonymsLOC207678, Gm10178
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL01557
Quality Score
Status
Chromosome1
Chromosomal Location154201187-154205689 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 154204680 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 195 (V195D)
Ref Sequence ENSEMBL: ENSMUSP00000083370 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086195]
Predicted Effect probably benign
Transcript: ENSMUST00000086195
AA Change: V195D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: V195D

DomainStartEndE-ValueType
ZnF_C2H2 236 258 1.82e-3 SMART
ZnF_C2H2 264 286 1.28e-3 SMART
ZnF_C2H2 292 315 1.2e-3 SMART
ZnF_C2H2 321 343 1.95e-3 SMART
ZnF_C2H2 349 371 8.94e-3 SMART
ZnF_C2H2 377 399 8.34e-3 SMART
ZnF_C2H2 405 427 4.54e-4 SMART
ZnF_C2H2 433 455 4.47e-3 SMART
ZnF_C2H2 461 483 5.81e-2 SMART
ZnF_C2H2 489 511 1.2e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 T A 18: 58,968,720 probably null Het
Arl9 T G 5: 77,004,101 probably null Het
Ces3a C A 8: 105,057,751 T439K probably damaging Het
Cyp3a25 A G 5: 145,984,901 W408R probably damaging Het
Defb22 T G 2: 152,486,079 D62A possibly damaging Het
Dnah17 C T 11: 118,073,686 R2422Q probably damaging Het
Ehd3 A G 17: 73,805,280 K13R probably benign Het
Fndc1 T C 17: 7,756,389 E1406G probably damaging Het
Gak A C 5: 108,584,337 Y762D probably damaging Het
Igf2r A G 17: 12,704,635 S1187P possibly damaging Het
Ighmbp2 T C 19: 3,281,472 E68G probably benign Het
Itpr2 T C 6: 146,158,976 T2448A probably damaging Het
Lrrk2 T G 15: 91,699,989 C317W probably damaging Het
Morc1 T A 16: 48,498,766 S278T probably damaging Het
Mrps9 T C 1: 42,851,350 V20A probably benign Het
Nutm1 A T 2: 112,251,818 N304K probably benign Het
Olfr761 G A 17: 37,952,851 P58S probably damaging Het
Pcdhb9 T C 18: 37,403,047 V698A probably damaging Het
Pitrm1 C A 13: 6,552,684 D70E probably benign Het
Pkhd1 T C 1: 20,116,979 T3702A possibly damaging Het
Ppm1h A T 10: 122,782,181 probably null Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Ptpn5 T C 7: 47,081,888 Y411C probably damaging Het
Spon2 G A 5: 33,216,703 A112V probably damaging Het
Other mutations in Zfp648
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp648 APN 1 154204189 missense possibly damaging 0.88
IGL01150:Zfp648 APN 1 154205364 missense probably damaging 1.00
IGL01757:Zfp648 APN 1 154204925 missense probably damaging 0.98
IGL02247:Zfp648 APN 1 154204177 missense probably benign 0.01
PIT4519001:Zfp648 UTSW 1 154204941 missense probably damaging 0.98
R0001:Zfp648 UTSW 1 154205286 missense probably damaging 1.00
R0256:Zfp648 UTSW 1 154205668 missense probably benign 0.08
R0266:Zfp648 UTSW 1 154204886 missense probably damaging 1.00
R0371:Zfp648 UTSW 1 154204667 missense possibly damaging 0.66
R1498:Zfp648 UTSW 1 154205373 missense probably damaging 1.00
R1562:Zfp648 UTSW 1 154204392 missense probably benign
R1687:Zfp648 UTSW 1 154204242 missense probably benign 0.15
R2128:Zfp648 UTSW 1 154204607 missense probably benign
R2427:Zfp648 UTSW 1 154205073 missense probably damaging 1.00
R2567:Zfp648 UTSW 1 154204949 missense probably damaging 0.98
R2844:Zfp648 UTSW 1 154205135 nonsense probably null
R3711:Zfp648 UTSW 1 154204558 missense probably benign 0.30
R4491:Zfp648 UTSW 1 154205127 missense probably damaging 1.00
R4693:Zfp648 UTSW 1 154204406 missense probably benign 0.01
R5666:Zfp648 UTSW 1 154204217 missense probably benign 0.00
R5670:Zfp648 UTSW 1 154204217 missense probably benign 0.00
R7432:Zfp648 UTSW 1 154205037 missense possibly damaging 0.84
R8069:Zfp648 UTSW 1 154204116 missense not run
Z1088:Zfp648 UTSW 1 154204520 missense probably benign 0.00
Posted On2013-12-09