Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01919:Map3k21'

180051

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Map3k21

Ensembl Gene

ENSMUSG00000031853

Gene Name

mitogen-activated protein kinase kinase kinase 21

Synonyms

BC021891

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.151) question?

Stock #

IGL01919

Quality Score

Status

Chromosome

Chromosomal Location

126637189-126674179 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 126668871 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 819 (E819V)

Ref Sequence

ENSEMBL: ENSMUSP00000034316 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034316]

AlphaFold

Q8VDG6

Predicted Effect

probably damaging
Transcript: ENSMUST00000034316
AA Change: E819V

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000034316
Gene: ENSMUSG00000031853
AA Change: E819V

Domain	Start	End	E-Value	Type
SH3	27	87	1.1e-18	SMART
TyrKc	110	382	6.04e-82	SMART
coiled coil region	402	474	N/A	INTRINSIC
low complexity region	478	492	N/A	INTRINSIC
low complexity region	661	677	N/A	INTRINSIC
low complexity region	740	758	N/A	INTRINSIC
low complexity region	766	788	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700062C07Rik	A	G	18: 24,608,580 (GRCm39)		probably null	Het
Alms1	T	C	6: 85,604,986 (GRCm39)	F2212S	possibly damaging	Het
Anpep	T	C	7: 79,475,098 (GRCm39)	I155V	possibly damaging	Het
Aoc1	G	A	6: 48,885,223 (GRCm39)	V653M	probably damaging	Het
Arl8b	T	C	6: 108,798,518 (GRCm39)		probably benign	Het
Bax	A	C	7: 45,115,552 (GRCm39)		probably null	Het
Cpne7	G	A	8: 123,852,382 (GRCm39)	E195K	probably damaging	Het
Csmd3	A	G	15: 47,539,168 (GRCm39)	I2330T	possibly damaging	Het
Dnajc16	A	G	4: 141,501,940 (GRCm39)	S297P	probably benign	Het
Farp2	A	G	1: 93,504,155 (GRCm39)	K311E	probably damaging	Het
Fhad1	A	G	4: 141,691,906 (GRCm39)	L410P	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm12185	T	C	11: 48,798,886 (GRCm39)	T536A	possibly damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Hydin	C	T	8: 111,245,806 (GRCm39)	T2173I	possibly damaging	Het
Kpnb1	A	G	11: 97,055,556 (GRCm39)	V783A	probably benign	Het
Krt1	A	G	15: 101,754,811 (GRCm39)	V509A	unknown	Het
Lrwd1	A	T	5: 136,164,729 (GRCm39)	L26*	probably null	Het
Mal2	T	A	15: 54,451,728 (GRCm39)	W50R	probably damaging	Het
Mrgprx3-ps	T	C	7: 46,959,959 (GRCm39)	T11A	probably benign	Het
Mroh2b	T	C	15: 4,953,170 (GRCm39)	F635L	probably benign	Het
Mylip	G	A	13: 45,562,178 (GRCm39)	E327K	probably damaging	Het
Nfix	T	C	8: 85,453,103 (GRCm39)	D308G	probably damaging	Het
Or1l8	G	A	2: 36,817,824 (GRCm39)	Q101*	probably null	Het
Or7e166	G	A	9: 19,624,638 (GRCm39)	V172I	probably benign	Het
Psma6	A	G	12: 55,454,254 (GRCm39)	E26G	probably damaging	Het
Rgs16	T	A	1: 153,617,804 (GRCm39)	S105T	probably damaging	Het
Slc25a23	T	A	17: 57,354,291 (GRCm39)	N372Y	possibly damaging	Het
Slc35e2	A	G	4: 155,697,187 (GRCm39)	M234V	probably benign	Het
Tbc1d8	A	G	1: 39,431,334 (GRCm39)	V346A	probably damaging	Het
Tgfb1i1	C	T	7: 127,847,654 (GRCm39)		probably benign	Het
Triml2	A	C	8: 43,643,349 (GRCm39)	T177P	probably damaging	Het
Uba6	T	C	5: 86,267,245 (GRCm39)	T959A	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het

Other mutations in Map3k21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00494:Map3k21	APN	8	126,671,412 (GRCm39)	missense	possibly damaging	0.52
IGL02065:Map3k21	APN	8	126,668,397 (GRCm39)	missense	probably benign	0.01
IGL02123:Map3k21	APN	8	126,652,849 (GRCm39)	missense	probably damaging	1.00
IGL02127:Map3k21	APN	8	126,668,886 (GRCm39)	missense	probably benign
IGL02863:Map3k21	APN	8	126,654,280 (GRCm39)	missense	probably benign	0.02
IGL03194:Map3k21	APN	8	126,650,801 (GRCm39)	missense	possibly damaging	0.90
PIT4142001:Map3k21	UTSW	8	126,664,047 (GRCm39)	missense	probably damaging	0.98
R0238:Map3k21	UTSW	8	126,671,709 (GRCm39)	missense	possibly damaging	0.67
R0238:Map3k21	UTSW	8	126,671,709 (GRCm39)	missense	possibly damaging	0.67
R0454:Map3k21	UTSW	8	126,668,858 (GRCm39)	missense	probably benign
R0654:Map3k21	UTSW	8	126,668,759 (GRCm39)	missense	probably benign	0.07
R1141:Map3k21	UTSW	8	126,668,471 (GRCm39)	missense	probably benign	0.32
R1177:Map3k21	UTSW	8	126,671,577 (GRCm39)	missense	probably benign	0.31
R1463:Map3k21	UTSW	8	126,668,876 (GRCm39)	missense	probably benign	0.00
R1472:Map3k21	UTSW	8	126,668,417 (GRCm39)	missense	probably benign
R1759:Map3k21	UTSW	8	126,671,519 (GRCm39)	missense	probably benign
R1988:Map3k21	UTSW	8	126,654,294 (GRCm39)	missense	probably benign	0.07
R2058:Map3k21	UTSW	8	126,665,461 (GRCm39)	missense	probably benign	0.01
R2117:Map3k21	UTSW	8	126,650,781 (GRCm39)	missense	probably benign	0.19
R2157:Map3k21	UTSW	8	126,664,005 (GRCm39)	missense	probably benign
R2436:Map3k21	UTSW	8	126,668,354 (GRCm39)	nonsense	probably null
R2507:Map3k21	UTSW	8	126,666,677 (GRCm39)	missense	possibly damaging	0.73
R3125:Map3k21	UTSW	8	126,668,593 (GRCm39)	missense	probably benign	0.26
R3746:Map3k21	UTSW	8	126,661,839 (GRCm39)	missense	probably damaging	1.00
R4016:Map3k21	UTSW	8	126,637,924 (GRCm39)	missense	probably damaging	1.00
R4647:Map3k21	UTSW	8	126,668,850 (GRCm39)	missense	probably benign
R4648:Map3k21	UTSW	8	126,668,850 (GRCm39)	missense	probably benign
R4864:Map3k21	UTSW	8	126,654,294 (GRCm39)	missense	probably benign	0.04
R5642:Map3k21	UTSW	8	126,665,563 (GRCm39)	missense	probably benign	0.17
R5694:Map3k21	UTSW	8	126,671,507 (GRCm39)	missense	probably benign	0.04
R5950:Map3k21	UTSW	8	126,668,499 (GRCm39)	missense	possibly damaging	0.93
R5982:Map3k21	UTSW	8	126,638,169 (GRCm39)	missense	probably damaging	1.00
R6440:Map3k21	UTSW	8	126,637,876 (GRCm39)	missense	probably damaging	1.00
R6550:Map3k21	UTSW	8	126,664,031 (GRCm39)	missense	probably damaging	1.00
R6664:Map3k21	UTSW	8	126,668,610 (GRCm39)	missense	probably benign	0.01
R6668:Map3k21	UTSW	8	126,652,852 (GRCm39)	missense	possibly damaging	0.60
R6788:Map3k21	UTSW	8	126,666,605 (GRCm39)	missense	probably benign	0.28
R7369:Map3k21	UTSW	8	126,637,855 (GRCm39)	missense	possibly damaging	0.86
R7371:Map3k21	UTSW	8	126,661,804 (GRCm39)	missense	probably damaging	0.99
R7381:Map3k21	UTSW	8	126,671,717 (GRCm39)	missense	possibly damaging	0.83
R7388:Map3k21	UTSW	8	126,654,336 (GRCm39)	missense	probably damaging	1.00
R7397:Map3k21	UTSW	8	126,661,855 (GRCm39)	missense	probably damaging	1.00
R7497:Map3k21	UTSW	8	126,654,340 (GRCm39)	missense	probably damaging	0.99
R7562:Map3k21	UTSW	8	126,665,539 (GRCm39)	missense	probably damaging	1.00
R7564:Map3k21	UTSW	8	126,654,447 (GRCm39)	critical splice donor site	probably null
R7824:Map3k21	UTSW	8	126,637,702 (GRCm39)	missense	probably benign	0.01
R8286:Map3k21	UTSW	8	126,637,498 (GRCm39)	missense	probably benign	0.00
R8351:Map3k21	UTSW	8	126,671,472 (GRCm39)	missense	probably benign	0.00
R8451:Map3k21	UTSW	8	126,671,472 (GRCm39)	missense	probably benign	0.00
R8461:Map3k21	UTSW	8	126,671,361 (GRCm39)	missense	probably benign	0.05
R9005:Map3k21	UTSW	8	126,637,471 (GRCm39)	missense
R9074:Map3k21	UTSW	8	126,664,050 (GRCm39)	missense	probably damaging	0.98
R9156:Map3k21	UTSW	8	126,665,463 (GRCm39)	missense	possibly damaging	0.81
R9217:Map3k21	UTSW	8	126,638,027 (GRCm39)	missense	possibly damaging	0.47
R9474:Map3k21	UTSW	8	126,650,903 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07