Incidental Mutation 'IGL01942:Rasl12'
ID180879
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rasl12
Ensembl Gene ENSMUSG00000041696
Gene NameRAS-like, family 12
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL01942
Quality Score
Status
Chromosome9
Chromosomal Location65398506-65414853 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 65408362 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 96 (V96A)
Ref Sequence ENSEMBL: ENSMUSP00000131837 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065894] [ENSMUST00000085453] [ENSMUST00000165682] [ENSMUST00000217172]
Predicted Effect probably benign
Transcript: ENSMUST00000065894
SMART Domains Protein: ENSMUSP00000064494
Gene: ENSMUSG00000053862

DomainStartEndE-ValueType
Pfam:OSTbeta 1 122 1.1e-55 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000085453
AA Change: V96A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000082580
Gene: ENSMUSG00000041696
AA Change: V96A

DomainStartEndE-ValueType
Pfam:Arf 15 154 4e-7 PFAM
Pfam:Roc 22 138 1.5e-8 PFAM
Pfam:Ras 22 185 9.7e-33 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000165682
AA Change: V96A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131837
Gene: ENSMUSG00000041696
AA Change: V96A

DomainStartEndE-ValueType
Pfam:Arf 15 155 3.9e-8 PFAM
Pfam:Miro 22 137 9.2e-14 PFAM
Pfam:Ras 22 159 1.7e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217172
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 G A 7: 45,986,573 R1017W possibly damaging Het
Arhgef26 A G 3: 62,340,094 R200G probably benign Het
Arid4b A T 13: 14,136,164 probably benign Het
Atp1a2 A C 1: 172,286,309 S369A probably benign Het
Bag3 T A 7: 128,546,300 D546E probably benign Het
Bcl6b T A 11: 70,226,743 Y379F probably damaging Het
Cbln2 T C 18: 86,716,325 V136A probably benign Het
Ccnf A T 17: 24,242,320 D120E probably benign Het
Cd14 T A 18: 36,725,640 H254L possibly damaging Het
Chd3 A G 11: 69,350,105 probably null Het
Csf2rb G A 15: 78,340,492 R150H probably benign Het
Dhx35 T C 2: 158,831,864 L405P probably damaging Het
Dpf1 G A 7: 29,316,502 C383Y probably damaging Het
Dse T A 10: 34,155,993 Q345L probably benign Het
Gnaz A G 10: 75,014,874 M244V probably damaging Het
Gpr65 A T 12: 98,275,715 Y209F possibly damaging Het
Inpp5f T C 7: 128,667,769 I281T probably damaging Het
Kntc1 T C 5: 123,778,267 F721S probably damaging Het
Mapk8ip2 G A 15: 89,457,017 probably null Het
Med24 G A 11: 98,709,682 R646W probably damaging Het
Nup98 A T 7: 102,194,711 F102Y probably damaging Het
Olfr1260 G T 2: 89,977,978 V67L probably benign Het
Olfr150 A T 9: 39,737,666 M284L possibly damaging Het
Olfr354 A G 2: 36,907,857 M304V probably benign Het
Pgap3 T C 11: 98,397,954 Y125C probably damaging Het
Rbm20 G A 19: 53,813,443 M127I probably damaging Het
Rnf114 T A 2: 167,512,626 probably null Het
Serpinb1b C T 13: 33,085,311 T9I possibly damaging Het
Setd1b T A 5: 123,163,426 F16I possibly damaging Het
Slc25a28 A G 19: 43,664,508 F238S probably damaging Het
Slc2a2 T C 3: 28,705,803 V30A probably damaging Het
Slc35f4 T C 14: 49,525,505 probably benign Het
Socs4 T A 14: 47,290,650 C347* probably null Het
Spock1 C T 13: 57,430,328 E367K probably damaging Het
Ubap2 C T 4: 41,251,608 R8H probably benign Het
Vmn1r44 T A 6: 89,893,824 M41K probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp575 T C 7: 24,585,815 T134A possibly damaging Het
Other mutations in Rasl12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02268:Rasl12 APN 9 65398664 missense probably damaging 1.00
IGL02293:Rasl12 APN 9 65408311 missense probably benign 0.02
R0755:Rasl12 UTSW 9 65410959 missense probably benign
R1334:Rasl12 UTSW 9 65410869 missense probably damaging 1.00
R2063:Rasl12 UTSW 9 65410824 missense probably damaging 1.00
R2872:Rasl12 UTSW 9 65408323 missense probably benign 0.10
R2872:Rasl12 UTSW 9 65408323 missense probably benign 0.10
R2874:Rasl12 UTSW 9 65408323 missense probably benign 0.10
R4456:Rasl12 UTSW 9 65398584 missense probably null 1.00
R4785:Rasl12 UTSW 9 65413448 missense probably damaging 0.99
R5391:Rasl12 UTSW 9 65398667 missense probably damaging 0.96
R7008:Rasl12 UTSW 9 65410869 missense probably damaging 1.00
X0058:Rasl12 UTSW 9 65408329 missense possibly damaging 0.92
Posted On2014-05-07