Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01950:Vmn2r71'

181291

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r71

Ensembl Gene

ENSMUSG00000091205

Gene Name

vomeronasal 2, receptor 71

Synonyms

EG233445

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL01950

Quality Score

Status

Chromosome

Chromosomal Location

85264670-85273755 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85264827 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 53 (Y53C)

Ref Sequence

ENSEMBL: ENSMUSP00000132337 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172338]

AlphaFold

L7N2D8

Predicted Effect

probably damaging
Transcript: ENSMUST00000172338
AA Change: Y53C

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000132337
Gene: ENSMUSG00000091205
AA Change: Y53C

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.1e-31	PFAM
Pfam:NCD3G	511	563	8.7e-20	PFAM
Pfam:7tm_3	593	831	2e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208273

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208545

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adm	G	A	7: 110,228,107 (GRCm39)	R96H	probably damaging	Het
Aebp1	C	T	11: 5,819,108 (GRCm39)	T198I	probably benign	Het
Arid3b	A	T	9: 57,702,257 (GRCm39)	I500N	probably damaging	Het
Clec1b	T	A	6: 129,377,043 (GRCm39)	W29R	probably damaging	Het
Cyp2e1	T	C	7: 140,344,874 (GRCm39)		probably null	Het
Dnah5	A	G	15: 28,290,435 (GRCm39)	E1275G	probably null	Het
Dnajc13	A	T	9: 104,067,631 (GRCm39)	I1171N	possibly damaging	Het
Dpf3	T	G	12: 83,371,723 (GRCm39)	T171P	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Hk1	T	C	10: 62,151,173 (GRCm39)	D57G	probably damaging	Het
Kcnc2	T	G	10: 112,297,980 (GRCm39)		probably benign	Het
Kcnj11	A	T	7: 45,748,573 (GRCm39)	F250Y	probably damaging	Het
Kirrel3	C	T	9: 34,939,625 (GRCm39)		probably benign	Het
Lmbrd1	T	C	1: 24,750,683 (GRCm39)		probably null	Het
Mga	T	C	2: 119,772,135 (GRCm39)	V1665A	possibly damaging	Het
Ms4a3	G	T	19: 11,610,199 (GRCm39)	A121E	probably damaging	Het
Nfix	T	C	8: 85,440,415 (GRCm39)	*392W	probably null	Het
Noxred1	C	T	12: 87,268,190 (GRCm39)	V314M	probably damaging	Het
Or2t47	A	T	11: 58,442,560 (GRCm39)	C168*	probably null	Het
Or51aa5	T	A	7: 103,167,472 (GRCm39)	T40S	probably benign	Het
Phospho1	A	G	11: 95,719,548 (GRCm39)		probably benign	Het
Prr5	G	A	15: 84,650,550 (GRCm39)	A237T	probably benign	Het
Rev3l	C	T	10: 39,697,153 (GRCm39)	T550M	probably damaging	Het
Sbf2	A	G	7: 109,965,032 (GRCm39)	F955L	probably benign	Het
Slc38a9	C	T	13: 112,831,787 (GRCm39)	T179M	probably damaging	Het
Trpv5	T	G	6: 41,652,912 (GRCm39)	D87A	probably benign	Het
Tubgcp5	A	G	7: 55,455,836 (GRCm39)	Q288R	possibly damaging	Het
Uqcc1	A	G	2: 155,700,058 (GRCm39)	Y172H	probably damaging	Het
Vmn2r23	T	C	6: 123,718,845 (GRCm39)	F733L	possibly damaging	Het
Vwa5a	T	A	9: 38,638,266 (GRCm39)	M263K	probably damaging	Het
Zfp503	C	A	14: 22,036,488 (GRCm39)	A143S	probably benign	Het
Zfp958	T	C	8: 4,678,917 (GRCm39)	L314P	probably damaging	Het

Other mutations in Vmn2r71

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00922:Vmn2r71	APN	7	85,267,901 (GRCm39)	missense	probably benign
IGL00960:Vmn2r71	APN	7	85,273,582 (GRCm39)	missense	probably damaging	1.00
IGL01372:Vmn2r71	APN	7	85,270,022 (GRCm39)	splice site	probably benign
IGL01690:Vmn2r71	APN	7	85,264,782 (GRCm39)	missense	probably damaging	1.00
IGL01909:Vmn2r71	APN	7	85,270,001 (GRCm39)	missense	probably benign	0.00
IGL02570:Vmn2r71	APN	7	85,264,748 (GRCm39)	missense	possibly damaging	0.95
IGL02650:Vmn2r71	APN	7	85,273,535 (GRCm39)	missense	probably damaging	1.00
IGL02901:Vmn2r71	APN	7	85,268,470 (GRCm39)	missense	probably benign	0.00
IGL03128:Vmn2r71	APN	7	85,268,795 (GRCm39)	missense	probably damaging	1.00
IGL03328:Vmn2r71	APN	7	85,273,499 (GRCm39)	missense	probably damaging	1.00
R0533:Vmn2r71	UTSW	7	85,268,426 (GRCm39)	frame shift	probably null
R0707:Vmn2r71	UTSW	7	85,268,640 (GRCm39)	missense	probably benign
R0841:Vmn2r71	UTSW	7	85,267,749 (GRCm39)	missense	possibly damaging	0.62
R0865:Vmn2r71	UTSW	7	85,268,516 (GRCm39)	missense	probably benign	0.01
R0883:Vmn2r71	UTSW	7	85,272,842 (GRCm39)	missense	probably benign	0.19
R0939:Vmn2r71	UTSW	7	85,272,889 (GRCm39)	missense	possibly damaging	0.70
R1597:Vmn2r71	UTSW	7	85,273,352 (GRCm39)	missense	possibly damaging	0.46
R1646:Vmn2r71	UTSW	7	85,270,476 (GRCm39)	missense	probably damaging	0.99
R1719:Vmn2r71	UTSW	7	85,270,435 (GRCm39)	missense	probably damaging	1.00
R1860:Vmn2r71	UTSW	7	85,264,782 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2014:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2015:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2050:Vmn2r71	UTSW	7	85,273,681 (GRCm39)	missense	probably damaging	1.00
R2084:Vmn2r71	UTSW	7	85,267,945 (GRCm39)	missense	probably benign	0.03
R2221:Vmn2r71	UTSW	7	85,273,301 (GRCm39)	missense	probably benign	0.40
R2223:Vmn2r71	UTSW	7	85,273,301 (GRCm39)	missense	probably benign	0.40
R2245:Vmn2r71	UTSW	7	85,273,388 (GRCm39)	missense	probably damaging	1.00
R3115:Vmn2r71	UTSW	7	85,272,866 (GRCm39)	missense	probably damaging	0.97
R3122:Vmn2r71	UTSW	7	85,264,828 (GRCm39)	nonsense	probably null
R3609:Vmn2r71	UTSW	7	85,268,870 (GRCm39)	missense	probably damaging	1.00
R4093:Vmn2r71	UTSW	7	85,270,442 (GRCm39)	missense	probably benign	0.00
R4305:Vmn2r71	UTSW	7	85,273,360 (GRCm39)	missense	probably damaging	1.00
R4306:Vmn2r71	UTSW	7	85,273,360 (GRCm39)	missense	probably damaging	1.00
R4334:Vmn2r71	UTSW	7	85,269,042 (GRCm39)	missense	probably benign	0.01
R4569:Vmn2r71	UTSW	7	85,273,402 (GRCm39)	missense	possibly damaging	0.66
R4622:Vmn2r71	UTSW	7	85,269,817 (GRCm39)	missense	probably benign	0.00
R4915:Vmn2r71	UTSW	7	85,270,476 (GRCm39)	missense	probably damaging	0.99
R4956:Vmn2r71	UTSW	7	85,268,436 (GRCm39)	missense	probably benign	0.19
R5005:Vmn2r71	UTSW	7	85,273,352 (GRCm39)	missense	probably damaging	1.00
R5045:Vmn2r71	UTSW	7	85,273,597 (GRCm39)	missense	probably benign	0.00
R5153:Vmn2r71	UTSW	7	85,268,430 (GRCm39)	missense	possibly damaging	0.94
R5236:Vmn2r71	UTSW	7	85,272,877 (GRCm39)	missense	probably damaging	1.00
R5373:Vmn2r71	UTSW	7	85,267,750 (GRCm39)	missense	possibly damaging	0.79
R5405:Vmn2r71	UTSW	7	85,268,622 (GRCm39)	missense	probably benign
R5831:Vmn2r71	UTSW	7	85,272,922 (GRCm39)	missense	probably benign	0.16
R6061:Vmn2r71	UTSW	7	85,268,482 (GRCm39)	missense	probably benign
R6518:Vmn2r71	UTSW	7	85,270,436 (GRCm39)	missense	probably damaging	1.00
R6751:Vmn2r71	UTSW	7	85,269,095 (GRCm39)	critical splice donor site	probably null
R6920:Vmn2r71	UTSW	7	85,273,108 (GRCm39)	missense	probably damaging	1.00
R7358:Vmn2r71	UTSW	7	85,273,468 (GRCm39)	missense	possibly damaging	0.81
R7453:Vmn2r71	UTSW	7	85,273,297 (GRCm39)	missense	probably benign	0.21
R7560:Vmn2r71	UTSW	7	85,273,115 (GRCm39)	missense	probably benign	0.06
R7871:Vmn2r71	UTSW	7	85,272,869 (GRCm39)	missense	possibly damaging	0.81
R8267:Vmn2r71	UTSW	7	85,264,704 (GRCm39)	missense	probably benign	0.02
R8377:Vmn2r71	UTSW	7	85,264,707 (GRCm39)	missense	probably benign
R9278:Vmn2r71	UTSW	7	85,269,788 (GRCm39)	missense	probably benign	0.19
R9319:Vmn2r71	UTSW	7	85,273,694 (GRCm39)	missense	probably damaging	1.00
R9329:Vmn2r71	UTSW	7	85,267,950 (GRCm39)	missense	probably benign	0.00
R9368:Vmn2r71	UTSW	7	85,273,442 (GRCm39)	missense	probably damaging	1.00
R9636:Vmn2r71	UTSW	7	85,268,388 (GRCm39)	missense	possibly damaging	0.80
R9756:Vmn2r71	UTSW	7	85,268,573 (GRCm39)	nonsense	probably null
X0025:Vmn2r71	UTSW	7	85,267,873 (GRCm39)	missense	probably benign
Z1186:Vmn2r71	UTSW	7	85,273,094 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07