Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02650:Vmn2r71'

302104

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r71

Ensembl Gene

ENSMUSG00000091205

Gene Name

vomeronasal 2, receptor 71

Synonyms

EG233445

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02650

Quality Score

Status

Chromosome

Chromosomal Location

85264670-85273755 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85273535 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 783 (M783K)

Ref Sequence

ENSEMBL: ENSMUSP00000132337 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172338]

AlphaFold

L7N2D8

Predicted Effect

probably damaging
Transcript: ENSMUST00000172338
AA Change: M783K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000132337
Gene: ENSMUSG00000091205
AA Change: M783K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.1e-31	PFAM
Pfam:NCD3G	511	563	8.7e-20	PFAM
Pfam:7tm_3	593	831	2e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208273

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	A	G	2: 68,571,881 (GRCm39)	T586A	probably benign	Het
Acads	G	T	5: 115,250,874 (GRCm39)	T141N	probably benign	Het
Ankmy1	C	T	1: 92,808,745 (GRCm39)	R721H	probably damaging	Het
Appl1	A	G	14: 26,672,665 (GRCm39)	V236A	possibly damaging	Het
Arhgef5	C	T	6: 43,249,869 (GRCm39)	Q207*	probably null	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Atp6v0a2	G	T	5: 124,789,426 (GRCm39)		probably benign	Het
Cenpf	T	C	1: 189,384,670 (GRCm39)	K2537E	possibly damaging	Het
Cox7a1	A	T	7: 29,884,562 (GRCm39)	E32V	possibly damaging	Het
Dis3	A	T	14: 99,336,221 (GRCm39)	M95K	probably benign	Het
Dnah5	A	T	15: 28,289,193 (GRCm39)		probably benign	Het
Dock10	T	A	1: 80,551,840 (GRCm39)	Y665F	probably damaging	Het
Dynlt5	C	A	4: 102,845,803 (GRCm39)	Q12K	probably benign	Het
Ghsr	A	T	3: 27,429,004 (GRCm39)	Q343L	probably benign	Het
Gm3252	T	A	14: 4,746,353 (GRCm38)	V215E	probably damaging	Het
Gm9979	A	G	13: 40,859,225 (GRCm39)		noncoding transcript	Het
Grik2	A	T	10: 48,977,331 (GRCm39)	M867K	probably benign	Het
Grm7	A	G	6: 111,335,919 (GRCm39)	T777A	probably damaging	Het
Hc	T	A	2: 34,890,886 (GRCm39)	Q1310L	possibly damaging	Het
Ifi44	A	G	3: 151,451,492 (GRCm39)	F205L	probably damaging	Het
Igkv4-86	T	C	6: 68,887,617 (GRCm39)	I40V	probably benign	Het
Jag1	T	C	2: 136,957,505 (GRCm39)	D69G	possibly damaging	Het
Lrch1	T	C	14: 75,051,138 (GRCm39)	D333G	probably damaging	Het
Mapre3	T	A	5: 31,022,053 (GRCm39)	I187N	probably damaging	Het
Myo15b	T	C	11: 115,777,337 (GRCm39)		probably null	Het
Nanos2	C	T	7: 18,721,794 (GRCm39)	P89S	probably damaging	Het
Or4c109	T	A	2: 88,818,424 (GRCm39)	M41L	probably benign	Het
Parp16	G	A	9: 65,141,098 (GRCm39)	V223I	probably damaging	Het
Rnf123	A	G	9: 107,946,947 (GRCm39)	M231T	probably benign	Het
Suco	C	A	1: 161,676,322 (GRCm39)		probably benign	Het
Synj1	G	T	16: 90,773,584 (GRCm39)	T459N	probably benign	Het
Taf4b	C	T	18: 14,975,040 (GRCm39)	Q732*	probably null	Het
Tas2r102	A	G	6: 132,739,173 (GRCm39)	N27S	probably null	Het
Tll1	C	T	8: 64,500,031 (GRCm39)		probably benign	Het
Vmn1r168	A	G	7: 23,240,916 (GRCm39)	I258V	probably benign	Het
Vmn2r98	G	A	17: 19,301,223 (GRCm39)	V742I	probably benign	Het

Other mutations in Vmn2r71

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00922:Vmn2r71	APN	7	85,267,901 (GRCm39)	missense	probably benign
IGL00960:Vmn2r71	APN	7	85,273,582 (GRCm39)	missense	probably damaging	1.00
IGL01372:Vmn2r71	APN	7	85,270,022 (GRCm39)	splice site	probably benign
IGL01690:Vmn2r71	APN	7	85,264,782 (GRCm39)	missense	probably damaging	1.00
IGL01909:Vmn2r71	APN	7	85,270,001 (GRCm39)	missense	probably benign	0.00
IGL01950:Vmn2r71	APN	7	85,264,827 (GRCm39)	missense	probably damaging	0.98
IGL02570:Vmn2r71	APN	7	85,264,748 (GRCm39)	missense	possibly damaging	0.95
IGL02901:Vmn2r71	APN	7	85,268,470 (GRCm39)	missense	probably benign	0.00
IGL03128:Vmn2r71	APN	7	85,268,795 (GRCm39)	missense	probably damaging	1.00
IGL03328:Vmn2r71	APN	7	85,273,499 (GRCm39)	missense	probably damaging	1.00
R0533:Vmn2r71	UTSW	7	85,268,426 (GRCm39)	frame shift	probably null
R0707:Vmn2r71	UTSW	7	85,268,640 (GRCm39)	missense	probably benign
R0841:Vmn2r71	UTSW	7	85,267,749 (GRCm39)	missense	possibly damaging	0.62
R0865:Vmn2r71	UTSW	7	85,268,516 (GRCm39)	missense	probably benign	0.01
R0883:Vmn2r71	UTSW	7	85,272,842 (GRCm39)	missense	probably benign	0.19
R0939:Vmn2r71	UTSW	7	85,272,889 (GRCm39)	missense	possibly damaging	0.70
R1597:Vmn2r71	UTSW	7	85,273,352 (GRCm39)	missense	possibly damaging	0.46
R1646:Vmn2r71	UTSW	7	85,270,476 (GRCm39)	missense	probably damaging	0.99
R1719:Vmn2r71	UTSW	7	85,270,435 (GRCm39)	missense	probably damaging	1.00
R1860:Vmn2r71	UTSW	7	85,264,782 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2014:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2015:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2050:Vmn2r71	UTSW	7	85,273,681 (GRCm39)	missense	probably damaging	1.00
R2084:Vmn2r71	UTSW	7	85,267,945 (GRCm39)	missense	probably benign	0.03
R2221:Vmn2r71	UTSW	7	85,273,301 (GRCm39)	missense	probably benign	0.40
R2223:Vmn2r71	UTSW	7	85,273,301 (GRCm39)	missense	probably benign	0.40
R2245:Vmn2r71	UTSW	7	85,273,388 (GRCm39)	missense	probably damaging	1.00
R3115:Vmn2r71	UTSW	7	85,272,866 (GRCm39)	missense	probably damaging	0.97
R3122:Vmn2r71	UTSW	7	85,264,828 (GRCm39)	nonsense	probably null
R3609:Vmn2r71	UTSW	7	85,268,870 (GRCm39)	missense	probably damaging	1.00
R4093:Vmn2r71	UTSW	7	85,270,442 (GRCm39)	missense	probably benign	0.00
R4305:Vmn2r71	UTSW	7	85,273,360 (GRCm39)	missense	probably damaging	1.00
R4306:Vmn2r71	UTSW	7	85,273,360 (GRCm39)	missense	probably damaging	1.00
R4334:Vmn2r71	UTSW	7	85,269,042 (GRCm39)	missense	probably benign	0.01
R4569:Vmn2r71	UTSW	7	85,273,402 (GRCm39)	missense	possibly damaging	0.66
R4622:Vmn2r71	UTSW	7	85,269,817 (GRCm39)	missense	probably benign	0.00
R4915:Vmn2r71	UTSW	7	85,270,476 (GRCm39)	missense	probably damaging	0.99
R4956:Vmn2r71	UTSW	7	85,268,436 (GRCm39)	missense	probably benign	0.19
R5005:Vmn2r71	UTSW	7	85,273,352 (GRCm39)	missense	probably damaging	1.00
R5045:Vmn2r71	UTSW	7	85,273,597 (GRCm39)	missense	probably benign	0.00
R5153:Vmn2r71	UTSW	7	85,268,430 (GRCm39)	missense	possibly damaging	0.94
R5236:Vmn2r71	UTSW	7	85,272,877 (GRCm39)	missense	probably damaging	1.00
R5373:Vmn2r71	UTSW	7	85,267,750 (GRCm39)	missense	possibly damaging	0.79
R5405:Vmn2r71	UTSW	7	85,268,622 (GRCm39)	missense	probably benign
R5831:Vmn2r71	UTSW	7	85,272,922 (GRCm39)	missense	probably benign	0.16
R6061:Vmn2r71	UTSW	7	85,268,482 (GRCm39)	missense	probably benign
R6518:Vmn2r71	UTSW	7	85,270,436 (GRCm39)	missense	probably damaging	1.00
R6751:Vmn2r71	UTSW	7	85,269,095 (GRCm39)	critical splice donor site	probably null
R6920:Vmn2r71	UTSW	7	85,273,108 (GRCm39)	missense	probably damaging	1.00
R7358:Vmn2r71	UTSW	7	85,273,468 (GRCm39)	missense	possibly damaging	0.81
R7453:Vmn2r71	UTSW	7	85,273,297 (GRCm39)	missense	probably benign	0.21
R7560:Vmn2r71	UTSW	7	85,273,115 (GRCm39)	missense	probably benign	0.06
R7871:Vmn2r71	UTSW	7	85,272,869 (GRCm39)	missense	possibly damaging	0.81
R8267:Vmn2r71	UTSW	7	85,264,704 (GRCm39)	missense	probably benign	0.02
R8377:Vmn2r71	UTSW	7	85,264,707 (GRCm39)	missense	probably benign
R9278:Vmn2r71	UTSW	7	85,269,788 (GRCm39)	missense	probably benign	0.19
R9319:Vmn2r71	UTSW	7	85,273,694 (GRCm39)	missense	probably damaging	1.00
R9329:Vmn2r71	UTSW	7	85,267,950 (GRCm39)	missense	probably benign	0.00
R9368:Vmn2r71	UTSW	7	85,273,442 (GRCm39)	missense	probably damaging	1.00
R9636:Vmn2r71	UTSW	7	85,268,388 (GRCm39)	missense	possibly damaging	0.80
R9756:Vmn2r71	UTSW	7	85,268,573 (GRCm39)	nonsense	probably null
X0025:Vmn2r71	UTSW	7	85,267,873 (GRCm39)	missense	probably benign
Z1186:Vmn2r71	UTSW	7	85,273,094 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16