Incidental Mutation 'R1777:Robo1'
| ID |
197170 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo1
|
| Ensembl Gene |
ENSMUSG00000022883 |
| Gene Name |
roundabout guidance receptor 1 |
| Synonyms |
DUTT1 |
| MMRRC Submission |
039808-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1777 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
72105194-72842983 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 72801555 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Glycine
at position 1060
(W1060G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023600
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023600
AA Change: W1060G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000023600
Gene: ENSMUSG00000022883
AA Change: W1060G
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
41 |
115 |
3.15e-10 |
SMART |
|
IGc2
|
143 |
208 |
2.52e-9 |
SMART |
|
IGc2
|
235 |
298 |
3.85e-14 |
SMART |
|
IGv
|
328 |
391 |
3.71e-7 |
SMART |
|
IGc2
|
428 |
493 |
2.46e-12 |
SMART |
|
FN3
|
522 |
604 |
3.17e-13 |
SMART |
|
FN3
|
634 |
721 |
1.66e0 |
SMART |
|
FN3
|
736 |
822 |
4.28e-10 |
SMART |
|
low complexity region
|
1108 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1157 |
N/A |
INTRINSIC |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1298 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1442 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1563 |
1576 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1611 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000232205
AA Change: W1069G
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232264
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232432
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 92.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930444P10Rik |
T |
A |
1: 16,148,813 (GRCm39) |
D111V |
possibly damaging |
Het |
| Ap2a1 |
G |
A |
7: 44,553,576 (GRCm39) |
T597M |
probably damaging |
Het |
| Arhgap25 |
A |
G |
6: 87,440,289 (GRCm39) |
S364P |
probably benign |
Het |
| Atp6v1a |
G |
T |
16: 43,935,068 (GRCm39) |
Y40* |
probably null |
Het |
| Cdh1 |
T |
A |
8: 107,383,467 (GRCm39) |
H235Q |
probably damaging |
Het |
| Cntln |
A |
G |
4: 85,048,916 (GRCm39) |
E1376G |
probably benign |
Het |
| Cntnap5b |
T |
A |
1: 100,297,803 (GRCm39) |
S781T |
probably benign |
Het |
| Cpne4 |
A |
G |
9: 104,749,887 (GRCm39) |
T64A |
probably damaging |
Het |
| Ctsg |
T |
C |
14: 56,338,058 (GRCm39) |
Y179C |
probably damaging |
Het |
| Cx3cr1 |
A |
G |
9: 119,880,659 (GRCm39) |
Y248H |
probably damaging |
Het |
| Dhx37 |
T |
C |
5: 125,506,995 (GRCm39) |
E167G |
probably benign |
Het |
| Dnajc21 |
C |
A |
15: 10,449,693 (GRCm39) |
A443S |
probably benign |
Het |
| Drd5 |
T |
C |
5: 38,477,504 (GRCm39) |
S166P |
probably damaging |
Het |
| Dscaml1 |
T |
C |
9: 45,595,054 (GRCm39) |
L719P |
possibly damaging |
Het |
| Eif2ak4 |
T |
C |
2: 118,261,320 (GRCm39) |
I542T |
probably damaging |
Het |
| Ephb3 |
G |
A |
16: 21,035,985 (GRCm39) |
G291E |
probably damaging |
Het |
| Eva1a |
T |
A |
6: 82,069,137 (GRCm39) |
Y155N |
probably damaging |
Het |
| Exog |
C |
T |
9: 119,278,884 (GRCm39) |
P189L |
probably damaging |
Het |
| Fam13b |
A |
G |
18: 34,590,813 (GRCm39) |
V455A |
possibly damaging |
Het |
| Fmn2 |
C |
A |
1: 174,409,488 (GRCm39) |
Q574K |
unknown |
Het |
| Gm6871 |
A |
T |
7: 41,195,143 (GRCm39) |
S531R |
probably benign |
Het |
| Golga2 |
T |
A |
2: 32,195,482 (GRCm39) |
|
probably null |
Het |
| Hydin |
C |
T |
8: 111,316,203 (GRCm39) |
P4365L |
probably benign |
Het |
| Ints8 |
A |
T |
4: 11,225,600 (GRCm39) |
|
probably null |
Het |
| Kbtbd12 |
A |
C |
6: 88,595,042 (GRCm39) |
S263A |
probably benign |
Het |
| Kcng4 |
T |
C |
8: 120,360,226 (GRCm39) |
D50G |
probably benign |
Het |
| Klhl18 |
A |
T |
9: 110,266,469 (GRCm39) |
C217S |
probably benign |
Het |
| Klk1b4 |
A |
G |
7: 43,856,875 (GRCm39) |
|
probably benign |
Het |
| Klk7 |
G |
A |
7: 43,462,753 (GRCm39) |
C186Y |
probably damaging |
Het |
| Krbox5 |
A |
T |
13: 67,981,984 (GRCm39) |
R65S |
probably benign |
Het |
| Krit1 |
T |
C |
5: 3,886,799 (GRCm39) |
Y635H |
probably damaging |
Het |
| Lipo4 |
A |
T |
19: 33,476,721 (GRCm39) |
D342E |
probably damaging |
Het |
| Lsm14b |
T |
G |
2: 179,673,588 (GRCm39) |
D199E |
probably benign |
Het |
| Map3k4 |
A |
T |
17: 12,490,617 (GRCm39) |
N271K |
possibly damaging |
Het |
| Mast1 |
T |
A |
8: 85,638,697 (GRCm39) |
N1544I |
probably benign |
Het |
| Megf6 |
T |
A |
4: 154,355,147 (GRCm39) |
C1487* |
probably null |
Het |
| Mlh3 |
C |
A |
12: 85,315,528 (GRCm39) |
K219N |
possibly damaging |
Het |
| Mtmr4 |
A |
G |
11: 87,493,656 (GRCm39) |
K305E |
probably damaging |
Het |
| Myo15a |
A |
G |
11: 60,405,762 (GRCm39) |
M3105V |
probably benign |
Het |
| Nbas |
A |
T |
12: 13,563,563 (GRCm39) |
I1958F |
probably benign |
Het |
| Nepro |
A |
T |
16: 44,556,216 (GRCm39) |
Q458L |
probably damaging |
Het |
| Opa3 |
T |
C |
7: 18,978,837 (GRCm39) |
Y101H |
probably damaging |
Het |
| Or11g25 |
T |
A |
14: 50,723,757 (GRCm39) |
F281I |
probably benign |
Het |
| Or14c41 |
T |
A |
7: 86,235,272 (GRCm39) |
I263N |
probably benign |
Het |
| Or4f15 |
T |
A |
2: 111,814,042 (GRCm39) |
I126L |
possibly damaging |
Het |
| Or51f1d |
T |
C |
7: 102,700,583 (GRCm39) |
I26T |
probably benign |
Het |
| Or5ac16 |
A |
G |
16: 59,022,379 (GRCm39) |
S137P |
probably benign |
Het |
| Or8b12 |
A |
G |
9: 37,657,607 (GRCm39) |
Y59C |
possibly damaging |
Het |
| Pate3 |
T |
C |
9: 35,559,412 (GRCm39) |
N2D |
probably benign |
Het |
| Pcdhb21 |
T |
A |
18: 37,648,771 (GRCm39) |
D633E |
possibly damaging |
Het |
| Pgm2 |
C |
T |
5: 64,285,125 (GRCm39) |
P589L |
probably benign |
Het |
| Pigg |
T |
A |
5: 108,465,257 (GRCm39) |
D163E |
probably damaging |
Het |
| Polq |
A |
G |
16: 36,880,586 (GRCm39) |
T638A |
possibly damaging |
Het |
| Prmt3 |
T |
A |
7: 49,448,094 (GRCm39) |
M268K |
possibly damaging |
Het |
| Prmt9 |
T |
C |
8: 78,291,737 (GRCm39) |
C370R |
probably benign |
Het |
| Prss57 |
A |
T |
10: 79,623,219 (GRCm39) |
V76E |
possibly damaging |
Het |
| Psme3ip1 |
T |
C |
8: 95,315,439 (GRCm39) |
E31G |
probably damaging |
Het |
| Pzp |
T |
C |
6: 128,467,535 (GRCm39) |
E1089G |
possibly damaging |
Het |
| Qars1 |
T |
A |
9: 108,385,400 (GRCm39) |
|
probably null |
Het |
| Ralgapb |
T |
C |
2: 158,304,115 (GRCm39) |
Y625H |
probably damaging |
Het |
| Rgl2 |
G |
A |
17: 34,150,718 (GRCm39) |
D59N |
probably benign |
Het |
| Scaper |
A |
T |
9: 55,771,830 (GRCm39) |
V362E |
probably benign |
Het |
| Schip1 |
T |
C |
3: 68,525,017 (GRCm39) |
F131S |
probably damaging |
Het |
| Sh2b2 |
A |
T |
5: 136,256,276 (GRCm39) |
V252D |
probably damaging |
Het |
| Shld2 |
C |
A |
14: 33,990,130 (GRCm39) |
V259L |
probably benign |
Het |
| Slc17a6 |
A |
T |
7: 51,295,957 (GRCm39) |
H199L |
possibly damaging |
Het |
| Slc29a1 |
A |
G |
17: 45,898,234 (GRCm39) |
Y325H |
probably damaging |
Het |
| Slc29a4 |
G |
T |
5: 142,699,817 (GRCm39) |
W156L |
probably damaging |
Het |
| Slc5a3 |
T |
A |
16: 91,874,644 (GRCm39) |
S234T |
probably benign |
Het |
| Srd5a3 |
T |
G |
5: 76,297,630 (GRCm39) |
V20G |
probably damaging |
Het |
| Stac |
A |
T |
9: 111,433,150 (GRCm39) |
S223T |
possibly damaging |
Het |
| Sytl2 |
A |
T |
7: 90,052,260 (GRCm39) |
T766S |
probably benign |
Het |
| Tas2r102 |
A |
G |
6: 132,739,254 (GRCm39) |
D54G |
probably benign |
Het |
| Tbpl1 |
A |
G |
10: 22,583,742 (GRCm39) |
V105A |
probably damaging |
Het |
| Tenm3 |
G |
T |
8: 48,870,214 (GRCm39) |
P193Q |
probably benign |
Het |
| Tes |
G |
A |
6: 17,104,754 (GRCm39) |
V403M |
probably benign |
Het |
| Tgfbr2 |
A |
C |
9: 115,938,948 (GRCm39) |
I318S |
probably damaging |
Het |
| Tgfbr3 |
C |
A |
5: 107,284,796 (GRCm39) |
V618L |
probably benign |
Het |
| Tmc1 |
C |
T |
19: 20,793,473 (GRCm39) |
|
probably null |
Het |
| Tmem132a |
G |
A |
19: 10,835,870 (GRCm39) |
H887Y |
probably damaging |
Het |
| Tmem43 |
C |
A |
6: 91,454,312 (GRCm39) |
S33* |
probably null |
Het |
| Tob1 |
A |
G |
11: 94,104,580 (GRCm39) |
K39E |
probably damaging |
Het |
| Tut7 |
A |
T |
13: 59,939,635 (GRCm39) |
H705Q |
probably damaging |
Het |
| Unc79 |
T |
A |
12: 103,078,714 (GRCm39) |
D1433E |
probably damaging |
Het |
| Usp25 |
T |
C |
16: 76,878,442 (GRCm39) |
M622T |
probably damaging |
Het |
| Vmn1r158 |
A |
T |
7: 22,489,855 (GRCm39) |
L118Q |
probably damaging |
Het |
| Vmn1r217 |
T |
A |
13: 23,298,495 (GRCm39) |
I136L |
probably benign |
Het |
| Vmn2r15 |
A |
T |
5: 109,442,136 (GRCm39) |
I99K |
possibly damaging |
Het |
| Vwa7 |
T |
A |
17: 35,243,924 (GRCm39) |
V786E |
probably damaging |
Het |
| Xkr5 |
A |
G |
8: 18,989,148 (GRCm39) |
F248S |
probably benign |
Het |
| Zzef1 |
A |
T |
11: 72,801,098 (GRCm39) |
K2444M |
probably damaging |
Het |
|
| Other mutations in Robo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01766:Robo1
|
APN |
16 |
72,801,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01937:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Robo1
|
APN |
16 |
72,786,504 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Robo1
|
APN |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02282:Robo1
|
APN |
16 |
72,539,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Robo1
|
APN |
16 |
72,840,020 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02874:Robo1
|
APN |
16 |
72,809,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02974:Robo1
|
APN |
16 |
72,803,750 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03233:Robo1
|
APN |
16 |
72,767,081 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Robo1
|
UTSW |
16 |
72,801,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Robo1
|
UTSW |
16 |
72,730,230 (GRCm39) |
splice site |
probably benign |
|
|
R0254:Robo1
|
UTSW |
16 |
72,461,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0366:Robo1
|
UTSW |
16 |
72,539,133 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0410:Robo1
|
UTSW |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0511:Robo1
|
UTSW |
16 |
72,810,013 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0563:Robo1
|
UTSW |
16 |
72,769,174 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0637:Robo1
|
UTSW |
16 |
72,798,839 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1239:Robo1
|
UTSW |
16 |
72,821,430 (GRCm39) |
splice site |
probably null |
|
|
R1773:Robo1
|
UTSW |
16 |
72,801,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1902:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1903:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1996:Robo1
|
UTSW |
16 |
72,767,067 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2040:Robo1
|
UTSW |
16 |
72,730,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2266:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2269:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2433:Robo1
|
UTSW |
16 |
72,767,127 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Robo1
|
UTSW |
16 |
72,801,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3085:Robo1
|
UTSW |
16 |
72,798,898 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3150:Robo1
|
UTSW |
16 |
72,767,157 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3418:Robo1
|
UTSW |
16 |
72,832,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3610:Robo1
|
UTSW |
16 |
72,780,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3940:Robo1
|
UTSW |
16 |
72,806,631 (GRCm39) |
missense |
probably benign |
|
|
R3953:Robo1
|
UTSW |
16 |
72,821,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Robo1
|
UTSW |
16 |
72,757,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Robo1
|
UTSW |
16 |
72,768,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4814:Robo1
|
UTSW |
16 |
72,768,923 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4884:Robo1
|
UTSW |
16 |
72,701,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Robo1
|
UTSW |
16 |
72,776,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5150:Robo1
|
UTSW |
16 |
72,769,192 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5183:Robo1
|
UTSW |
16 |
72,539,038 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5360:Robo1
|
UTSW |
16 |
72,732,665 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5629:Robo1
|
UTSW |
16 |
72,780,598 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5804:Robo1
|
UTSW |
16 |
72,840,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6107:Robo1
|
UTSW |
16 |
72,780,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6127:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6128:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6129:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6191:Robo1
|
UTSW |
16 |
72,730,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6357:Robo1
|
UTSW |
16 |
72,767,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6408:Robo1
|
UTSW |
16 |
72,768,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6516:Robo1
|
UTSW |
16 |
72,821,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6600:Robo1
|
UTSW |
16 |
72,786,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Robo1
|
UTSW |
16 |
72,730,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7105:Robo1
|
UTSW |
16 |
72,539,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7189:Robo1
|
UTSW |
16 |
72,757,039 (GRCm39) |
nonsense |
probably null |
|
|
R7290:Robo1
|
UTSW |
16 |
72,801,408 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7296:Robo1
|
UTSW |
16 |
72,786,519 (GRCm39) |
nonsense |
probably null |
|
|
R7576:Robo1
|
UTSW |
16 |
72,767,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7605:Robo1
|
UTSW |
16 |
72,821,189 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7607:Robo1
|
UTSW |
16 |
72,360,626 (GRCm39) |
missense |
|
|
|
R7634:Robo1
|
UTSW |
16 |
72,839,866 (GRCm39) |
splice site |
probably null |
|
|
R7636:Robo1
|
UTSW |
16 |
72,360,615 (GRCm39) |
missense |
|
|
|
R7857:Robo1
|
UTSW |
16 |
72,767,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7966:Robo1
|
UTSW |
16 |
72,780,760 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7997:Robo1
|
UTSW |
16 |
72,701,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8101:Robo1
|
UTSW |
16 |
72,775,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8191:Robo1
|
UTSW |
16 |
72,730,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Robo1
|
UTSW |
16 |
72,786,678 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8228:Robo1
|
UTSW |
16 |
72,809,768 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8292:Robo1
|
UTSW |
16 |
72,769,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8298:Robo1
|
UTSW |
16 |
72,769,020 (GRCm39) |
intron |
probably benign |
|
|
R8332:Robo1
|
UTSW |
16 |
72,775,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8402:Robo1
|
UTSW |
16 |
72,821,385 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8492:Robo1
|
UTSW |
16 |
72,809,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8730:Robo1
|
UTSW |
16 |
72,786,495 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8774:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8776:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8776-TAIL:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8905:Robo1
|
UTSW |
16 |
72,539,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Robo1
|
UTSW |
16 |
72,701,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9003:Robo1
|
UTSW |
16 |
72,539,002 (GRCm39) |
splice site |
probably benign |
|
|
R9246:Robo1
|
UTSW |
16 |
72,769,178 (GRCm39) |
missense |
probably benign |
|
|
R9451:Robo1
|
UTSW |
16 |
72,803,718 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9509:Robo1
|
UTSW |
16 |
72,759,167 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9652:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9653:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9749:Robo1
|
UTSW |
16 |
72,105,257 (GRCm39) |
start gained |
probably benign |
|
|
Z1176:Robo1
|
UTSW |
16 |
72,774,688 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGGGATCGTAAATAACGCCGACAG -3'
(R):5'- TGCAGAACACTCAGGGAGATCAGAC -3'
Sequencing Primer
(F):5'- AGCCTGTGTGAATAGTTAACCCC -3'
(R):5'- CTCAGGGAGATCAGACAGGAAG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation