Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00925:Tango6'

28026

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tango6

Ensembl Gene

ENSMUSG00000041949

Gene Name

transport and golgi organization 6

Synonyms

Tango6, Tmco7

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00925

Quality Score

Status

Chromosome

Chromosomal Location

107409700-107578071 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 107422077 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148400 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048359] [ENSMUST00000211979]

AlphaFold

Q8C3S2

Predicted Effect

probably benign
Transcript: ENSMUST00000048359

SMART Domains

Protein: ENSMUSP00000043953
Gene: ENSMUSG00000041949

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
low complexity region	20	41	N/A	INTRINSIC
low complexity region	102	115	N/A	INTRINSIC
low complexity region	246	259	N/A	INTRINSIC
low complexity region	334	350	N/A	INTRINSIC
low complexity region	472	486	N/A	INTRINSIC
Pfam:RTP1_C1	824	935	1.6e-35	PFAM
low complexity region	998	1013	N/A	INTRINSIC
Pfam:RTP1_C2	1026	1059	7.5e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211979

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212764

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aoc1l2	T	A	6: 48,907,974 (GRCm39)	Y325N	probably damaging	Het
Atoh8	A	G	6: 72,211,553 (GRCm39)	V199A	probably benign	Het
Celf2	A	T	2: 6,726,388 (GRCm39)	D6E	probably benign	Het
Cep170	T	C	1: 176,621,090 (GRCm39)	D29G	probably damaging	Het
Cpb2	T	C	14: 75,498,190 (GRCm39)	Y118H	possibly damaging	Het
Esf1	A	G	2: 140,009,737 (GRCm39)	S200P	probably benign	Het
Glmn	A	T	5: 107,705,193 (GRCm39)	N474K	probably damaging	Het
Maea	T	C	5: 33,529,645 (GRCm39)	V377A	probably benign	Het
Npepps	A	G	11: 97,171,109 (GRCm39)	V59A	probably damaging	Het
Ocrl	A	G	X: 47,035,974 (GRCm39)	E565G	probably benign	Het
Or5al7	T	C	2: 85,993,264 (GRCm39)	T10A	probably benign	Het
Pclo	T	C	5: 14,816,755 (GRCm39)	S4544P	unknown	Het
Per3	T	C	4: 151,098,055 (GRCm39)	Y693C	probably benign	Het
Prkacb	G	T	3: 146,453,797 (GRCm39)	P167H	probably benign	Het
Ptprt	A	G	2: 161,498,083 (GRCm39)	S837P	possibly damaging	Het
Sema7a	G	T	9: 57,863,121 (GRCm39)	C264F	probably damaging	Het
Slitrk4	G	T	X: 63,315,657 (GRCm39)	P337T	probably damaging	Het
Tecta	T	C	9: 42,286,331 (GRCm39)	D775G	probably benign	Het
Tmem45a2	T	A	16: 56,865,618 (GRCm39)	N189Y	probably damaging	Het
Ttc8	A	G	12: 98,942,277 (GRCm39)	N364S	probably damaging	Het
Uhrf1	A	G	17: 56,627,535 (GRCm39)	D697G	probably benign	Het
Vmn1r185	G	A	7: 26,310,615 (GRCm39)	L297F	probably benign	Het
Vmn2r11	T	C	5: 109,194,885 (GRCm39)	T814A	probably benign	Het
Wdr36	A	G	18: 32,978,684 (GRCm39)	T198A	possibly damaging	Het
Zfhx2	G	A	14: 55,310,518 (GRCm39)	P676L	probably benign	Het
Zfp451	A	G	1: 33,815,342 (GRCm39)		probably benign	Het

Other mutations in Tango6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00905:Tango6	APN	8	107,469,104 (GRCm39)	critical splice donor site	probably null
IGL00965:Tango6	APN	8	107,468,642 (GRCm39)	splice site	probably benign
IGL01412:Tango6	APN	8	107,545,131 (GRCm39)	missense	probably benign	0.02
IGL02888:Tango6	APN	8	107,447,297 (GRCm39)	missense	probably damaging	1.00
IGL02892:Tango6	APN	8	107,468,642 (GRCm39)	splice site	probably benign
R0241:Tango6	UTSW	8	107,473,993 (GRCm39)	splice site	probably benign
R0494:Tango6	UTSW	8	107,462,314 (GRCm39)	splice site	probably benign
R1127:Tango6	UTSW	8	107,415,527 (GRCm39)	missense	probably benign	0.00
R1440:Tango6	UTSW	8	107,415,671 (GRCm39)	missense	probably damaging	1.00
R1547:Tango6	UTSW	8	107,508,418 (GRCm39)	missense	probably damaging	0.98
R1921:Tango6	UTSW	8	107,415,426 (GRCm39)	missense	probably benign	0.06
R2255:Tango6	UTSW	8	107,415,926 (GRCm39)	critical splice donor site	probably null
R2761:Tango6	UTSW	8	107,425,664 (GRCm39)	missense	possibly damaging	0.93
R4211:Tango6	UTSW	8	107,415,856 (GRCm39)	missense	probably benign	0.02
R4463:Tango6	UTSW	8	107,415,706 (GRCm39)	missense	probably benign	0.29
R4696:Tango6	UTSW	8	107,426,863 (GRCm39)	missense	possibly damaging	0.73
R4867:Tango6	UTSW	8	107,545,158 (GRCm39)	missense	probably damaging	1.00
R4946:Tango6	UTSW	8	107,444,722 (GRCm39)	nonsense	probably null
R5459:Tango6	UTSW	8	107,576,921 (GRCm39)	missense	probably damaging	1.00
R5522:Tango6	UTSW	8	107,422,230 (GRCm39)	critical splice donor site	probably null
R5795:Tango6	UTSW	8	107,444,709 (GRCm39)	missense	probably damaging	1.00
R5878:Tango6	UTSW	8	107,415,800 (GRCm39)	missense	possibly damaging	0.77
R6318:Tango6	UTSW	8	107,545,129 (GRCm39)	missense	probably benign
R6335:Tango6	UTSW	8	107,419,308 (GRCm39)	missense	possibly damaging	0.94
R6633:Tango6	UTSW	8	107,444,637 (GRCm39)	missense	probably benign	0.00
R6664:Tango6	UTSW	8	107,468,746 (GRCm39)	missense	probably damaging	1.00
R6838:Tango6	UTSW	8	107,468,706 (GRCm39)	missense	probably benign	0.00
R6866:Tango6	UTSW	8	107,469,104 (GRCm39)	critical splice donor site	probably null
R7046:Tango6	UTSW	8	107,533,748 (GRCm39)	missense	possibly damaging	0.86
R7130:Tango6	UTSW	8	107,533,733 (GRCm39)	missense	probably damaging	1.00
R7199:Tango6	UTSW	8	107,415,791 (GRCm39)	missense	probably benign	0.01
R7418:Tango6	UTSW	8	107,415,466 (GRCm39)	missense	probably benign	0.26
R7480:Tango6	UTSW	8	107,423,359 (GRCm39)	missense	possibly damaging	0.63
R7704:Tango6	UTSW	8	107,425,621 (GRCm39)	missense	probably benign	0.03
R7809:Tango6	UTSW	8	107,415,926 (GRCm39)	critical splice donor site	probably null
R7826:Tango6	UTSW	8	107,419,245 (GRCm39)	missense	probably benign	0.02
R8085:Tango6	UTSW	8	107,447,366 (GRCm39)	missense	probably benign	0.32
R8098:Tango6	UTSW	8	107,468,990 (GRCm39)	missense	possibly damaging	0.81
R8162:Tango6	UTSW	8	107,409,882 (GRCm39)	missense	possibly damaging	0.93
R8892:Tango6	UTSW	8	107,468,845 (GRCm39)	missense	probably benign	0.00
R8970:Tango6	UTSW	8	107,415,871 (GRCm39)	missense	probably damaging	0.98
R9336:Tango6	UTSW	8	107,415,701 (GRCm39)	missense	probably benign	0.03
R9760:Tango6	UTSW	8	107,576,911 (GRCm39)	missense	probably damaging	1.00
Z1177:Tango6	UTSW	8	107,423,248 (GRCm39)	missense	probably damaging	1.00
Z1177:Tango6	UTSW	8	107,415,424 (GRCm39)	missense	probably benign

Posted On

2013-04-17