Incidental Mutation 'IGL02208:Vmn2r56'
| ID |
284584 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r56
|
| Ensembl Gene |
ENSMUSG00000090762 |
| Gene Name |
vomeronasal 2, receptor 56 |
| Synonyms |
EG629079 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
IGL02208
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
12427787-12468785 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 12449408 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 277
(M277L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129566
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163852]
|
| AlphaFold |
A0A3B2WBA1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163852
AA Change: M277L
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000129566
Gene: ENSMUSG00000090762
AA Change: M277L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
5 |
397 |
1.9e-55 |
PFAM |
|
Pfam:NCD3G
|
439 |
492 |
6.4e-20 |
PFAM |
|
Pfam:7tm_3
|
523 |
760 |
1.3e-53 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
G |
11: 109,950,772 (GRCm39) |
Y898H |
probably damaging |
Het |
| Abr |
T |
C |
11: 76,346,471 (GRCm39) |
T484A |
probably damaging |
Het |
| Ahsg |
G |
A |
16: 22,711,060 (GRCm39) |
V66I |
possibly damaging |
Het |
| Arhgef5 |
T |
G |
6: 43,252,064 (GRCm39) |
D938E |
probably benign |
Het |
| Asap1 |
T |
A |
15: 63,993,882 (GRCm39) |
E731V |
probably damaging |
Het |
| Cdca2 |
C |
T |
14: 67,950,589 (GRCm39) |
R114Q |
probably damaging |
Het |
| Dock5 |
A |
G |
14: 68,065,899 (GRCm39) |
I368T |
probably benign |
Het |
| Dse |
T |
A |
10: 34,028,433 (GRCm39) |
M886L |
probably benign |
Het |
| Efcab11 |
A |
G |
12: 99,820,861 (GRCm39) |
|
probably benign |
Het |
| Eri2 |
G |
A |
7: 119,385,158 (GRCm39) |
P448S |
probably benign |
Het |
| Iffo1 |
A |
G |
6: 125,122,329 (GRCm39) |
D37G |
possibly damaging |
Het |
| Lrrc39 |
A |
T |
3: 116,371,923 (GRCm39) |
Q230L |
probably damaging |
Het |
| Macrod2 |
C |
A |
2: 142,216,196 (GRCm39) |
S443Y |
possibly damaging |
Het |
| Map4 |
T |
A |
9: 109,807,938 (GRCm39) |
M1K |
probably null |
Het |
| Misfa |
T |
C |
7: 46,633,572 (GRCm39) |
|
probably benign |
Het |
| Myh4 |
G |
A |
11: 67,142,760 (GRCm39) |
A974T |
possibly damaging |
Het |
| Npm3 |
T |
C |
19: 45,737,299 (GRCm39) |
T72A |
probably benign |
Het |
| Or14j1 |
T |
C |
17: 38,146,415 (GRCm39) |
F175S |
probably damaging |
Het |
| P3h4 |
T |
C |
11: 100,304,901 (GRCm39) |
N162S |
probably damaging |
Het |
| Pcnx2 |
G |
T |
8: 126,478,894 (GRCm39) |
T2118N |
probably benign |
Het |
| Pla2r1 |
G |
T |
2: 60,258,932 (GRCm39) |
P1152Q |
possibly damaging |
Het |
| Pole2 |
C |
T |
12: 69,269,936 (GRCm39) |
E63K |
possibly damaging |
Het |
| Polr3e |
T |
A |
7: 120,531,363 (GRCm39) |
F151I |
probably damaging |
Het |
| Prdm2 |
T |
C |
4: 142,862,313 (GRCm39) |
T326A |
probably benign |
Het |
| Prdm8 |
G |
T |
5: 98,331,324 (GRCm39) |
A59S |
possibly damaging |
Het |
| Reps1 |
A |
G |
10: 17,994,770 (GRCm39) |
N538S |
probably damaging |
Het |
| Scube1 |
T |
C |
15: 83,587,741 (GRCm39) |
D76G |
probably damaging |
Het |
| Senp6 |
T |
C |
9: 80,021,225 (GRCm39) |
F302L |
probably damaging |
Het |
| Skic2 |
A |
T |
17: 35,060,651 (GRCm39) |
I822N |
probably damaging |
Het |
| Slc17a7 |
T |
C |
7: 44,820,367 (GRCm39) |
I299T |
probably damaging |
Het |
| Slc25a26 |
T |
A |
6: 94,484,520 (GRCm39) |
V20E |
probably damaging |
Het |
| Spem2 |
T |
C |
11: 69,708,089 (GRCm39) |
|
probably null |
Het |
| Stat5b |
A |
C |
11: 100,695,739 (GRCm39) |
F81C |
probably damaging |
Het |
| Taf6 |
A |
T |
5: 138,179,169 (GRCm39) |
V423E |
probably damaging |
Het |
| Tcaf2 |
T |
A |
6: 42,606,020 (GRCm39) |
Y551F |
probably damaging |
Het |
| Tgm6 |
A |
T |
2: 129,977,790 (GRCm39) |
D43V |
probably benign |
Het |
| Tubb3 |
G |
T |
8: 124,147,603 (GRCm39) |
V179L |
probably damaging |
Het |
| Ubr1 |
G |
A |
2: 120,776,830 (GRCm39) |
H304Y |
probably benign |
Het |
| Wdr72 |
G |
A |
9: 74,064,581 (GRCm39) |
V538M |
probably damaging |
Het |
|
| Other mutations in Vmn2r56 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00902:Vmn2r56
|
APN |
7 |
12,449,426 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01060:Vmn2r56
|
APN |
7 |
12,447,016 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01433:Vmn2r56
|
APN |
7 |
12,449,541 (GRCm39) |
missense |
probably benign |
|
|
IGL01859:Vmn2r56
|
APN |
7 |
12,449,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Vmn2r56
|
APN |
7 |
12,449,602 (GRCm39) |
missense |
probably benign |
0.03 |
|
PIT4445001:Vmn2r56
|
UTSW |
7 |
12,449,153 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0077:Vmn2r56
|
UTSW |
7 |
12,449,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0278:Vmn2r56
|
UTSW |
7 |
12,449,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0512:Vmn2r56
|
UTSW |
7 |
12,449,350 (GRCm39) |
missense |
probably benign |
|
|
R0658:Vmn2r56
|
UTSW |
7 |
12,444,235 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0789:Vmn2r56
|
UTSW |
7 |
12,466,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1534:Vmn2r56
|
UTSW |
7 |
12,427,954 (GRCm39) |
missense |
probably benign |
|
|
R1731:Vmn2r56
|
UTSW |
7 |
12,466,972 (GRCm39) |
missense |
probably benign |
|
|
R1817:Vmn2r56
|
UTSW |
7 |
12,449,542 (GRCm39) |
missense |
probably benign |
|
|
R2047:Vmn2r56
|
UTSW |
7 |
12,466,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2139:Vmn2r56
|
UTSW |
7 |
12,446,890 (GRCm39) |
nonsense |
probably null |
|
|
R2160:Vmn2r56
|
UTSW |
7 |
12,428,146 (GRCm39) |
missense |
probably benign |
0.43 |
|
R2449:Vmn2r56
|
UTSW |
7 |
12,428,082 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2877:Vmn2r56
|
UTSW |
7 |
12,444,954 (GRCm39) |
missense |
probably benign |
|
|
R2878:Vmn2r56
|
UTSW |
7 |
12,444,954 (GRCm39) |
missense |
probably benign |
|
|
R4910:Vmn2r56
|
UTSW |
7 |
12,449,462 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5072:Vmn2r56
|
UTSW |
7 |
12,427,983 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5340:Vmn2r56
|
UTSW |
7 |
12,449,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5697:Vmn2r56
|
UTSW |
7 |
12,449,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5798:Vmn2r56
|
UTSW |
7 |
12,446,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6166:Vmn2r56
|
UTSW |
7 |
12,427,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Vmn2r56
|
UTSW |
7 |
12,428,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6458:Vmn2r56
|
UTSW |
7 |
12,427,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6751:Vmn2r56
|
UTSW |
7 |
12,428,719 (GRCm39) |
missense |
probably benign |
|
|
R6978:Vmn2r56
|
UTSW |
7 |
12,449,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7090:Vmn2r56
|
UTSW |
7 |
12,449,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7200:Vmn2r56
|
UTSW |
7 |
12,444,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7861:Vmn2r56
|
UTSW |
7 |
12,449,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8222:Vmn2r56
|
UTSW |
7 |
12,444,960 (GRCm39) |
missense |
probably benign |
|
|
R8282:Vmn2r56
|
UTSW |
7 |
12,449,601 (GRCm39) |
nonsense |
probably null |
|
|
R8786:Vmn2r56
|
UTSW |
7 |
12,449,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8970:Vmn2r56
|
UTSW |
7 |
12,428,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9230:Vmn2r56
|
UTSW |
7 |
12,444,237 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
RF002:Vmn2r56
|
UTSW |
7 |
12,428,757 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2015-04-16 |
Incidental Mutation