Incidental Mutation 'IGL02729:Tarsl2'
ID305364
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tarsl2
Ensembl Gene ENSMUSG00000030515
Gene Namethreonyl-tRNA synthetase-like 2
SynonymsA530046H20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.142) question?
Stock #IGL02729
Quality Score
Status
Chromosome7
Chromosomal Location65644898-65692091 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 65682819 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Methionine at position 556 (T556M)
Ref Sequence ENSEMBL: ENSMUSP00000032728 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032728]
Predicted Effect probably damaging
Transcript: ENSMUST00000032728
AA Change: T556M

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: T556M

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
coiled coil region 44 68 N/A INTRINSIC
Pfam:TGS 151 210 8.8e-14 PFAM
tRNA_SAD 316 365 1.26e-16 SMART
Pfam:tRNA-synt_2b 464 675 2.2e-35 PFAM
Pfam:HGTP_anticodon 687 778 1.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126941
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127354
Meta Mutation Damage Score 0.0368 question?
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,280,481 E1358G probably benign Het
Alpk1 T A 3: 127,681,072 L427F possibly damaging Het
Atat1 T C 17: 35,898,391 T326A probably benign Het
Calcr T A 6: 3,707,595 H235L probably benign Het
Cdc16 A G 8: 13,779,250 D512G possibly damaging Het
Cilp G A 9: 65,278,090 R489Q possibly damaging Het
Ddx4 C T 13: 112,651,412 probably benign Het
Dennd1c T C 17: 57,066,637 D612G probably benign Het
Hyal6 A C 6: 24,734,695 Y209S probably damaging Het
Irf4 T C 13: 30,753,591 probably null Het
Itgae T C 11: 73,118,203 probably benign Het
L3mbtl4 C T 17: 68,484,743 T272I probably benign Het
Lyst C A 13: 13,746,609 P3380Q possibly damaging Het
Lyst T C 13: 13,674,339 I2037T possibly damaging Het
Mgat4b A G 11: 50,233,309 I359V probably benign Het
Mybl1 A T 1: 9,672,570 D604E probably benign Het
Myh7b A T 2: 155,625,689 S745C probably damaging Het
Olfr155 C A 4: 43,854,439 N43K probably damaging Het
Olfr51 T C 11: 51,007,065 F31S probably damaging Het
Olfr805 T G 10: 129,723,521 I8L probably benign Het
Pced1a A T 2: 130,421,903 H276Q probably benign Het
Pdx1 C A 5: 147,274,614 P215Q probably benign Het
Pdzd7 T C 19: 45,045,643 M1V probably null Het
Prrc2b T A 2: 32,208,758 M621K probably damaging Het
Ptprh T G 7: 4,580,874 N240H probably damaging Het
Rsph1 T A 17: 31,273,319 E91V probably damaging Het
Scn1a A G 2: 66,299,650 C1274R probably damaging Het
Skint7 C A 4: 111,982,170 F220L probably benign Het
Skiv2l G A 17: 34,839,605 P1179S possibly damaging Het
Slit1 T A 19: 41,603,334 Y1283F probably damaging Het
Taf1b A G 12: 24,547,625 probably benign Het
Utrn A G 10: 12,720,810 probably benign Het
Wdr55 A G 18: 36,763,382 E375G probably benign Het
Zfp276 T C 8: 123,267,816 Y541H probably damaging Het
Zfp40 C T 17: 23,178,311 V3I probably damaging Het
Zfp536 T A 7: 37,493,718 H766L probably damaging Het
Zfyve21 A G 12: 111,825,051 I157V probably benign Het
Other mutations in Tarsl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Tarsl2 APN 7 65652259 critical splice acceptor site probably null
IGL00470:Tarsl2 APN 7 65688908 missense probably benign 0.03
IGL00594:Tarsl2 APN 7 65676132 critical splice donor site probably null
IGL01352:Tarsl2 APN 7 65658910 missense possibly damaging 0.80
IGL01519:Tarsl2 APN 7 65663886 missense probably damaging 1.00
IGL01726:Tarsl2 APN 7 65682818 missense possibly damaging 0.46
IGL02370:Tarsl2 APN 7 65661165 missense probably benign 0.17
IGL03234:Tarsl2 APN 7 65652278 missense probably benign 0.06
gary UTSW 7 65688952 critical splice donor site probably null
smart_money UTSW 7 65678142 missense probably damaging 1.00
R0127:Tarsl2 UTSW 7 65664969 missense probably benign 0.19
R0153:Tarsl2 UTSW 7 65684081 missense probably damaging 1.00
R0605:Tarsl2 UTSW 7 65678071 missense probably damaging 1.00
R1070:Tarsl2 UTSW 7 65655696 missense probably damaging 1.00
R1450:Tarsl2 UTSW 7 65647496 missense probably benign 0.01
R1467:Tarsl2 UTSW 7 65655696 missense probably damaging 1.00
R1467:Tarsl2 UTSW 7 65655696 missense probably damaging 1.00
R2142:Tarsl2 UTSW 7 65658897 missense probably benign
R2143:Tarsl2 UTSW 7 65655791 missense possibly damaging 0.57
R2144:Tarsl2 UTSW 7 65655791 missense possibly damaging 0.57
R2145:Tarsl2 UTSW 7 65655791 missense possibly damaging 0.57
R2208:Tarsl2 UTSW 7 65682848 missense probably damaging 1.00
R3713:Tarsl2 UTSW 7 65688952 critical splice donor site probably null
R3715:Tarsl2 UTSW 7 65688952 critical splice donor site probably null
R3914:Tarsl2 UTSW 7 65683808 missense probably benign 0.05
R3929:Tarsl2 UTSW 7 65684043 intron probably null
R4008:Tarsl2 UTSW 7 65678128 missense probably damaging 1.00
R4064:Tarsl2 UTSW 7 65652270 missense possibly damaging 0.90
R4367:Tarsl2 UTSW 7 65682819 missense probably damaging 0.97
R4652:Tarsl2 UTSW 7 65689969 missense probably damaging 1.00
R4825:Tarsl2 UTSW 7 65647554 missense probably benign 0.38
R4901:Tarsl2 UTSW 7 65691294 missense probably benign 0.05
R4999:Tarsl2 UTSW 7 65658935 missense probably damaging 0.99
R5423:Tarsl2 UTSW 7 65683819 missense probably benign 0.00
R5756:Tarsl2 UTSW 7 65675976 missense probably benign 0.22
R5772:Tarsl2 UTSW 7 65684125 missense probably damaging 1.00
R6160:Tarsl2 UTSW 7 65682779 missense probably benign 0.32
R6230:Tarsl2 UTSW 7 65686436 unclassified probably null
R6424:Tarsl2 UTSW 7 65655739 missense probably damaging 1.00
R6615:Tarsl2 UTSW 7 65678142 missense probably damaging 1.00
R6792:Tarsl2 UTSW 7 65662303 missense probably damaging 1.00
R7350:Tarsl2 UTSW 7 65658924 missense probably damaging 1.00
Posted On2015-04-16