Incidental Mutation 'R0390:Nav1'
| ID |
31562 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
038596-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.934)
|
| Stock # |
R0390 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 135377704 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1715
(D1715G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067241
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000040599
AA Change: D1715G
PolyPhen 2
Score 0.802 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: D1715G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000067414
AA Change: D1715G
PolyPhen 2
Score 0.802 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: D1715G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175639
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187311
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000190298
AA Change: D1655G
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
AA Change: D1655G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.2263 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.9%
- 20x: 92.0%
|
| Validation Efficiency |
98% (110/112) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam18 |
C |
T |
8: 25,164,070 (GRCm39) |
G38R |
probably benign |
Het |
| Ap2m1 |
T |
C |
16: 20,359,849 (GRCm39) |
M183T |
probably damaging |
Het |
| Apob |
A |
T |
12: 8,038,678 (GRCm39) |
I364F |
probably damaging |
Het |
| Arl6 |
A |
T |
16: 59,442,784 (GRCm39) |
|
probably benign |
Het |
| Cand2 |
A |
G |
6: 115,751,614 (GRCm39) |
M15V |
possibly damaging |
Het |
| Cbl |
A |
G |
9: 44,112,302 (GRCm39) |
F131S |
probably damaging |
Het |
| Ccdc74a |
A |
G |
16: 17,468,340 (GRCm39) |
S321G |
probably benign |
Het |
| Cdc14b |
T |
C |
13: 64,358,006 (GRCm39) |
|
probably benign |
Het |
| Cep152 |
T |
C |
2: 125,418,789 (GRCm39) |
|
probably benign |
Het |
| Cep290 |
A |
G |
10: 100,344,620 (GRCm39) |
E479G |
probably benign |
Het |
| Chrm2 |
T |
G |
6: 36,501,046 (GRCm39) |
I301R |
probably benign |
Het |
| Clec2e |
A |
G |
6: 129,070,431 (GRCm39) |
W197R |
probably damaging |
Het |
| Cnot10 |
G |
T |
9: 114,458,218 (GRCm39) |
S96* |
probably null |
Het |
| Col19a1 |
A |
G |
1: 24,328,736 (GRCm39) |
|
probably benign |
Het |
| Csmd2 |
T |
C |
4: 128,027,466 (GRCm39) |
|
probably benign |
Het |
| Cthrc1 |
A |
T |
15: 38,950,159 (GRCm39) |
*172L |
probably null |
Het |
| Cul9 |
A |
T |
17: 46,839,515 (GRCm39) |
I821N |
probably benign |
Het |
| Daam1 |
G |
C |
12: 72,022,078 (GRCm39) |
|
probably benign |
Het |
| Dhx58 |
A |
T |
11: 100,590,090 (GRCm39) |
I398N |
probably damaging |
Het |
| Dip2b |
T |
A |
15: 100,091,794 (GRCm39) |
H844Q |
probably damaging |
Het |
| Dmac2 |
A |
G |
7: 25,320,454 (GRCm39) |
D50G |
probably damaging |
Het |
| Dmxl1 |
C |
A |
18: 50,012,429 (GRCm39) |
Q1529K |
probably benign |
Het |
| Dtna |
C |
T |
18: 23,730,558 (GRCm39) |
P315L |
probably damaging |
Het |
| Ep300 |
T |
C |
15: 81,524,317 (GRCm39) |
S1382P |
unknown |
Het |
| Fat2 |
A |
T |
11: 55,201,603 (GRCm39) |
N490K |
probably damaging |
Het |
| Flg2 |
T |
A |
3: 93,107,662 (GRCm39) |
|
probably benign |
Het |
| Gpatch1 |
T |
C |
7: 34,980,806 (GRCm39) |
|
probably benign |
Het |
| Grin2a |
C |
A |
16: 9,397,449 (GRCm39) |
K879N |
possibly damaging |
Het |
| Hacd3 |
A |
C |
9: 64,908,304 (GRCm39) |
I164S |
possibly damaging |
Het |
| Hinfp |
A |
C |
9: 44,210,245 (GRCm39) |
C197G |
probably damaging |
Het |
| Hsd17b12 |
T |
C |
2: 93,945,335 (GRCm39) |
|
probably benign |
Het |
| Hsd3b1 |
A |
T |
3: 98,760,355 (GRCm39) |
L212Q |
probably damaging |
Het |
| Ifrd1 |
C |
T |
12: 40,264,093 (GRCm39) |
|
probably null |
Het |
| Igf2bp2 |
A |
G |
16: 21,900,551 (GRCm39) |
F129L |
possibly damaging |
Het |
| Kirrel3 |
T |
A |
9: 34,931,459 (GRCm39) |
I409N |
probably damaging |
Het |
| Klhdc10 |
T |
C |
6: 30,447,411 (GRCm39) |
I204T |
probably damaging |
Het |
| Kpna6 |
A |
T |
4: 129,551,597 (GRCm39) |
S65R |
possibly damaging |
Het |
| Lama3 |
A |
T |
18: 12,540,620 (GRCm39) |
D308V |
probably benign |
Het |
| Larp4b |
T |
A |
13: 9,208,143 (GRCm39) |
|
probably null |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Lyzl1 |
A |
T |
18: 4,169,175 (GRCm39) |
T11S |
probably benign |
Het |
| Man1c1 |
A |
G |
4: 134,305,626 (GRCm39) |
L366P |
probably damaging |
Het |
| Mef2a |
A |
G |
7: 66,901,472 (GRCm39) |
M100T |
probably damaging |
Het |
| Mettl13 |
G |
A |
1: 162,366,458 (GRCm39) |
H474Y |
possibly damaging |
Het |
| Minar2 |
T |
A |
18: 59,208,760 (GRCm39) |
V136E |
probably damaging |
Het |
| Mmp3 |
A |
G |
9: 7,451,320 (GRCm39) |
D352G |
probably benign |
Het |
| Mns1 |
T |
C |
9: 72,360,086 (GRCm39) |
I412T |
probably damaging |
Het |
| Mon2 |
T |
C |
10: 122,842,926 (GRCm39) |
D1501G |
probably null |
Het |
| Mylk |
G |
T |
16: 34,695,990 (GRCm39) |
G242W |
probably damaging |
Het |
| Nckap1l |
T |
C |
15: 103,362,310 (GRCm39) |
S2P |
probably damaging |
Het |
| Nek3 |
A |
T |
8: 22,618,745 (GRCm39) |
|
probably benign |
Het |
| Nfrkb |
A |
G |
9: 31,300,193 (GRCm39) |
|
probably benign |
Het |
| Nlrp4d |
T |
C |
7: 10,122,705 (GRCm39) |
D53G |
probably benign |
Het |
| Nol8 |
T |
C |
13: 49,815,628 (GRCm39) |
S561P |
probably damaging |
Het |
| Nuf2 |
A |
C |
1: 169,352,866 (GRCm39) |
|
probably benign |
Het |
| Odad3 |
T |
A |
9: 21,903,004 (GRCm39) |
H442L |
probably benign |
Het |
| Ofcc1 |
T |
A |
13: 40,168,789 (GRCm39) |
D866V |
possibly damaging |
Het |
| Optn |
A |
G |
2: 5,051,006 (GRCm39) |
L125P |
probably benign |
Het |
| Or5k3 |
A |
G |
16: 58,969,662 (GRCm39) |
I150V |
probably benign |
Het |
| Otoa |
T |
A |
7: 120,730,564 (GRCm39) |
F588Y |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,269,850 (GRCm39) |
|
probably null |
Het |
| Pde5a |
T |
G |
3: 122,629,232 (GRCm39) |
C635W |
probably damaging |
Het |
| Pdgfb |
A |
T |
15: 79,887,620 (GRCm39) |
|
probably null |
Het |
| Pih1d2 |
T |
A |
9: 50,532,346 (GRCm39) |
C135S |
probably damaging |
Het |
| Plcg1 |
G |
T |
2: 160,594,286 (GRCm39) |
C361F |
probably damaging |
Het |
| Ppp4r4 |
T |
C |
12: 103,567,619 (GRCm39) |
|
probably benign |
Het |
| Pramel26 |
T |
A |
4: 143,538,269 (GRCm39) |
D234V |
probably benign |
Het |
| Prdm10 |
G |
A |
9: 31,260,564 (GRCm39) |
|
probably null |
Het |
| Prex2 |
T |
A |
1: 11,159,930 (GRCm39) |
|
probably null |
Het |
| Prss56 |
T |
G |
1: 87,112,452 (GRCm39) |
|
probably null |
Het |
| Prtg |
A |
G |
9: 72,752,240 (GRCm39) |
K209E |
probably benign |
Het |
| Ptprc |
G |
A |
1: 138,050,313 (GRCm39) |
T36I |
possibly damaging |
Het |
| Rasgrp4 |
A |
G |
7: 28,845,285 (GRCm39) |
Y302C |
probably damaging |
Het |
| Rb1cc1 |
T |
A |
1: 6,318,858 (GRCm39) |
M759K |
probably damaging |
Het |
| Rbm15b |
T |
A |
9: 106,763,197 (GRCm39) |
M324L |
probably benign |
Het |
| Rcbtb2 |
T |
C |
14: 73,415,987 (GRCm39) |
V500A |
probably damaging |
Het |
| Rgs6 |
A |
G |
12: 83,180,451 (GRCm39) |
K434R |
probably damaging |
Het |
| Rims1 |
C |
T |
1: 22,635,607 (GRCm39) |
A125T |
possibly damaging |
Het |
| Robo3 |
A |
G |
9: 37,333,473 (GRCm39) |
V746A |
probably benign |
Het |
| Rtl1 |
C |
T |
12: 109,557,820 (GRCm39) |
E1340K |
unknown |
Het |
| Sacs |
G |
A |
14: 61,443,089 (GRCm39) |
D1712N |
possibly damaging |
Het |
| Samd4b |
G |
A |
7: 28,103,402 (GRCm39) |
P19S |
probably benign |
Het |
| Samhd1 |
T |
C |
2: 156,956,151 (GRCm39) |
Y347C |
probably damaging |
Het |
| Sema6d |
T |
A |
2: 124,500,410 (GRCm39) |
I393N |
probably damaging |
Het |
| Sigmar1 |
C |
T |
4: 41,741,243 (GRCm39) |
A4T |
probably benign |
Het |
| Skint9 |
C |
A |
4: 112,246,376 (GRCm39) |
L245F |
probably benign |
Het |
| Slc35f5 |
T |
C |
1: 125,512,832 (GRCm39) |
L372P |
probably damaging |
Het |
| Smc1b |
A |
T |
15: 84,950,478 (GRCm39) |
I1182N |
probably damaging |
Het |
| Smyd3 |
A |
G |
1: 178,785,138 (GRCm39) |
|
probably benign |
Het |
| Sptlc1 |
T |
C |
13: 53,491,648 (GRCm39) |
D417G |
probably benign |
Het |
| Sv2c |
T |
C |
13: 96,225,216 (GRCm39) |
N31S |
probably benign |
Het |
| Tjp1 |
T |
C |
7: 64,964,738 (GRCm39) |
D811G |
probably damaging |
Het |
| Top2b |
A |
G |
14: 16,418,442 (GRCm38) |
T1221A |
probably benign |
Het |
| Tph2 |
T |
C |
10: 115,010,014 (GRCm39) |
D182G |
probably damaging |
Het |
| Traf6 |
C |
T |
2: 101,518,933 (GRCm39) |
Q141* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,587,275 (GRCm39) |
D21574G |
probably damaging |
Het |
| Uba2 |
T |
A |
7: 33,850,446 (GRCm39) |
N367I |
probably benign |
Het |
| Ube2b |
T |
C |
11: 51,879,429 (GRCm39) |
|
probably benign |
Het |
| Ubr5 |
G |
T |
15: 38,030,916 (GRCm39) |
L426I |
probably benign |
Het |
| Ugt2a2 |
T |
A |
5: 87,612,007 (GRCm39) |
H301L |
probably benign |
Het |
| Upf2 |
T |
A |
2: 6,023,705 (GRCm39) |
|
probably benign |
Het |
| Utrn |
T |
C |
10: 12,585,804 (GRCm39) |
D991G |
probably benign |
Het |
| Vmn2r25 |
T |
C |
6: 123,800,140 (GRCm39) |
D734G |
probably damaging |
Het |
| Vmn2r68 |
C |
G |
7: 84,882,466 (GRCm39) |
|
probably null |
Het |
| Vmn2r68 |
T |
A |
7: 84,882,457 (GRCm39) |
|
probably benign |
Het |
| Vwf |
T |
A |
6: 125,603,324 (GRCm39) |
Y891* |
probably null |
Het |
| Wwox |
C |
T |
8: 115,433,018 (GRCm39) |
T228I |
probably benign |
Het |
| Zer1 |
C |
T |
2: 29,998,225 (GRCm39) |
|
probably benign |
Het |
| Zfp180 |
C |
T |
7: 23,804,132 (GRCm39) |
H184Y |
possibly damaging |
Het |
| Zfp68 |
A |
T |
5: 138,605,487 (GRCm39) |
Y279N |
probably benign |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,359 (GRCm39) |
nonsense |
probably null |
|
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0699:Nav1
|
UTSW |
1 |
135,380,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1939:Nav1
|
UTSW |
1 |
135,393,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Nav1
|
UTSW |
1 |
135,460,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7464:Nav1
|
UTSW |
1 |
135,512,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Nav1
|
UTSW |
1 |
135,379,986 (GRCm39) |
missense |
unknown |
|
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTCCCTCCAGGGGATAAGATACAAG -3'
(R):5'- CTGCCTTCCAGAGCTGCTACTTAAC -3'
Sequencing Primer
(F):5'- AGATATAAGATACTGCTTCCAGCC -3'
(R):5'- CTCCTGTCGCTTAAAAAGAAGTC -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation