Incidental Mutation 'R4646:Tet2'
| ID |
350222 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
041907-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4646 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
133169438-133250882 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 133193843 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 197
(M197K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143029
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
[ENSMUST00000197118]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098603
AA Change: M197K
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: M197K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196398
AA Change: M197K
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: M197K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197118
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700031F05Rik |
G |
T |
X: 101,904,515 (GRCm39) |
N132K |
possibly damaging |
Het |
| 2010315B03Rik |
T |
A |
9: 124,056,228 (GRCm39) |
Y232F |
probably benign |
Het |
| Acadl |
A |
T |
1: 66,870,602 (GRCm39) |
S428R |
probably benign |
Het |
| Adamts10 |
A |
G |
17: 33,764,529 (GRCm39) |
D683G |
probably damaging |
Het |
| Angptl4 |
G |
A |
17: 34,000,273 (GRCm39) |
P32S |
probably benign |
Het |
| Apob |
A |
G |
12: 8,062,759 (GRCm39) |
N134S |
probably benign |
Het |
| Atr |
G |
A |
9: 95,753,250 (GRCm39) |
|
probably null |
Het |
| B4galnt1 |
G |
A |
10: 127,003,705 (GRCm39) |
V223M |
probably damaging |
Het |
| Bbs10 |
A |
G |
10: 111,136,995 (GRCm39) |
K703E |
probably benign |
Het |
| C1galt1c1 |
A |
T |
X: 37,720,349 (GRCm39) |
S216T |
probably benign |
Het |
| C2cd3 |
A |
C |
7: 100,021,657 (GRCm39) |
|
probably benign |
Het |
| Clca4b |
A |
C |
3: 144,634,286 (GRCm39) |
H102Q |
probably benign |
Het |
| Cntrl |
T |
C |
2: 35,039,473 (GRCm39) |
I557T |
probably damaging |
Het |
| Col26a1 |
G |
A |
5: 136,876,404 (GRCm39) |
S72F |
probably damaging |
Het |
| Crocc2 |
G |
A |
1: 93,096,516 (GRCm39) |
V24M |
possibly damaging |
Het |
| Csmd1 |
T |
C |
8: 15,982,511 (GRCm39) |
I2719V |
possibly damaging |
Het |
| Cul9 |
C |
T |
17: 46,849,943 (GRCm39) |
W502* |
probably null |
Het |
| Dazl |
A |
T |
17: 50,595,183 (GRCm39) |
F84I |
probably damaging |
Het |
| Dcaf1 |
G |
T |
9: 106,724,006 (GRCm39) |
R478L |
probably benign |
Het |
| Dock5 |
T |
G |
14: 68,080,228 (GRCm39) |
I198L |
probably benign |
Het |
| Dock9 |
A |
T |
14: 121,823,658 (GRCm39) |
L1428H |
probably damaging |
Het |
| Dync1li1 |
T |
A |
9: 114,538,237 (GRCm39) |
V198E |
probably damaging |
Het |
| Egf |
A |
T |
3: 129,513,925 (GRCm39) |
C429S |
probably damaging |
Het |
| Ehmt1 |
T |
C |
2: 24,781,696 (GRCm39) |
E7G |
probably null |
Het |
| Ercc4 |
G |
T |
16: 12,965,438 (GRCm39) |
R690L |
probably damaging |
Het |
| Erich5 |
T |
C |
15: 34,471,112 (GRCm39) |
C114R |
possibly damaging |
Het |
| Etv1 |
T |
C |
12: 38,915,685 (GRCm39) |
S428P |
possibly damaging |
Het |
| Fbxo31 |
G |
T |
8: 122,286,755 (GRCm39) |
F174L |
probably benign |
Het |
| Fbxo33 |
T |
A |
12: 59,251,217 (GRCm39) |
I433L |
probably benign |
Het |
| Fez2 |
A |
T |
17: 78,720,357 (GRCm39) |
V99E |
probably damaging |
Het |
| Gabarapl2 |
A |
C |
8: 112,669,185 (GRCm39) |
K48Q |
probably damaging |
Het |
| Gfi1b |
T |
A |
2: 28,500,149 (GRCm39) |
H294L |
probably damaging |
Het |
| Gk2 |
A |
G |
5: 97,604,056 (GRCm39) |
S261P |
probably damaging |
Het |
| Gpr158 |
T |
C |
2: 21,831,864 (GRCm39) |
I988T |
probably benign |
Het |
| Grk3 |
G |
C |
5: 113,077,586 (GRCm39) |
H394D |
probably benign |
Het |
| Grm6 |
A |
G |
11: 50,748,033 (GRCm39) |
E381G |
probably benign |
Het |
| Gtf3c1 |
A |
T |
7: 125,258,266 (GRCm39) |
M1268K |
possibly damaging |
Het |
| Hikeshi |
A |
T |
7: 89,572,854 (GRCm39) |
I113N |
probably damaging |
Het |
| Hmg20b |
T |
A |
10: 81,184,416 (GRCm39) |
Q129L |
probably damaging |
Het |
| Hunk |
C |
A |
16: 90,272,791 (GRCm39) |
T365K |
probably damaging |
Het |
| Ints15 |
A |
T |
5: 143,293,740 (GRCm39) |
W246R |
probably damaging |
Het |
| Kdm5a |
T |
G |
6: 120,351,938 (GRCm39) |
V176G |
possibly damaging |
Het |
| Kif2a |
T |
A |
13: 107,098,693 (GRCm39) |
E691V |
probably damaging |
Het |
| Ly6e |
T |
C |
15: 74,830,510 (GRCm39) |
|
probably null |
Het |
| Map1b |
G |
T |
13: 99,568,977 (GRCm39) |
P1248Q |
unknown |
Het |
| Mettl25 |
A |
G |
10: 105,662,416 (GRCm39) |
S185P |
probably damaging |
Het |
| Mfap3l |
T |
A |
8: 61,124,184 (GRCm39) |
V142D |
probably damaging |
Het |
| Mip |
T |
A |
10: 128,062,922 (GRCm39) |
H122Q |
probably benign |
Het |
| Mkx |
G |
A |
18: 6,992,040 (GRCm39) |
T280I |
probably benign |
Het |
| Msi1 |
A |
T |
5: 115,589,514 (GRCm39) |
|
probably null |
Het |
| Mtcl2 |
T |
C |
2: 156,862,426 (GRCm39) |
E1501G |
probably damaging |
Het |
| Muc5b |
A |
G |
7: 141,416,377 (GRCm39) |
M3108V |
probably benign |
Het |
| Mybl1 |
A |
G |
1: 9,742,511 (GRCm39) |
S625P |
probably damaging |
Het |
| Myo7b |
C |
A |
18: 32,127,422 (GRCm39) |
V627F |
probably benign |
Het |
| Ndst3 |
A |
T |
3: 123,465,684 (GRCm39) |
I96N |
probably damaging |
Het |
| Nrp1 |
A |
T |
8: 129,184,425 (GRCm39) |
T357S |
probably benign |
Het |
| Obscn |
G |
T |
11: 59,015,396 (GRCm39) |
Y1050* |
probably null |
Het |
| Or2ak7 |
A |
G |
11: 58,575,556 (GRCm39) |
N286D |
probably damaging |
Het |
| Or2d4 |
A |
T |
7: 106,543,547 (GRCm39) |
N220K |
probably benign |
Het |
| Or2y1c |
A |
C |
11: 49,361,451 (GRCm39) |
I158L |
probably benign |
Het |
| Or4c107 |
T |
A |
2: 88,789,556 (GRCm39) |
F249I |
probably damaging |
Het |
| Or5d47 |
A |
T |
2: 87,804,142 (GRCm39) |
I289K |
probably benign |
Het |
| Or5i1 |
T |
C |
2: 87,613,565 (GRCm39) |
V227A |
possibly damaging |
Het |
| Otof |
T |
C |
5: 30,540,914 (GRCm39) |
E875G |
possibly damaging |
Het |
| Pick1 |
A |
T |
15: 79,133,137 (GRCm39) |
D399V |
probably benign |
Het |
| Pik3c2g |
T |
A |
6: 139,665,744 (GRCm39) |
S22T |
probably benign |
Het |
| Pnpla2 |
A |
G |
7: 141,038,574 (GRCm39) |
E276G |
possibly damaging |
Het |
| Pomk |
A |
T |
8: 26,473,633 (GRCm39) |
S107T |
probably damaging |
Het |
| Rbm46 |
A |
T |
3: 82,771,765 (GRCm39) |
D283E |
probably benign |
Het |
| Rimbp3 |
A |
G |
16: 17,030,962 (GRCm39) |
D1462G |
probably damaging |
Het |
| Rnf112 |
T |
A |
11: 61,342,936 (GRCm39) |
E230V |
probably damaging |
Het |
| Rock1 |
T |
C |
18: 10,112,391 (GRCm39) |
T455A |
probably benign |
Het |
| Rtp4 |
A |
T |
16: 23,428,790 (GRCm39) |
M18L |
probably benign |
Het |
| Scaf11 |
A |
T |
15: 96,317,981 (GRCm39) |
|
probably null |
Het |
| Schip1 |
T |
C |
3: 67,972,297 (GRCm39) |
V8A |
probably benign |
Het |
| Sec31b |
T |
C |
19: 44,515,060 (GRCm39) |
H351R |
probably benign |
Het |
| Sh3bp5l |
A |
G |
11: 58,237,177 (GRCm39) |
D378G |
probably benign |
Het |
| Sowahb |
T |
C |
5: 93,190,715 (GRCm39) |
D668G |
probably damaging |
Het |
| Spam1 |
A |
G |
6: 24,800,586 (GRCm39) |
T442A |
probably benign |
Het |
| Syt14 |
T |
A |
1: 192,615,633 (GRCm39) |
Y451F |
probably damaging |
Het |
| Tafa5 |
T |
G |
15: 87,604,783 (GRCm39) |
S115A |
probably damaging |
Het |
| Tdh |
A |
G |
14: 63,731,205 (GRCm39) |
L323P |
possibly damaging |
Het |
| Thbs1 |
G |
A |
2: 117,948,810 (GRCm39) |
A489T |
probably benign |
Het |
| Tnfaip1 |
C |
T |
11: 78,420,008 (GRCm39) |
R88Q |
probably damaging |
Het |
| Tnn |
T |
C |
1: 159,973,612 (GRCm39) |
M252V |
probably benign |
Het |
| Trdn |
G |
T |
10: 33,071,977 (GRCm39) |
E215* |
probably null |
Het |
| Trim55 |
T |
C |
3: 19,725,286 (GRCm39) |
F268L |
probably benign |
Het |
| Trmt112 |
T |
A |
19: 6,887,816 (GRCm39) |
V55E |
possibly damaging |
Het |
| Tube1 |
A |
G |
10: 39,018,363 (GRCm39) |
M147V |
possibly damaging |
Het |
| Ubn1 |
A |
G |
16: 4,895,851 (GRCm39) |
T966A |
probably damaging |
Het |
| Unc80 |
A |
G |
1: 66,708,394 (GRCm39) |
I2651V |
probably benign |
Het |
| Vmn1r172 |
G |
A |
7: 23,359,919 (GRCm39) |
R268H |
probably benign |
Het |
| Vmn1r231 |
T |
A |
17: 21,110,571 (GRCm39) |
I115F |
probably damaging |
Het |
| Vmn1r237 |
A |
G |
17: 21,534,400 (GRCm39) |
K41R |
probably benign |
Het |
| Vmn2r58 |
A |
T |
7: 41,509,935 (GRCm39) |
N547K |
probably damaging |
Het |
| Vmn2r74 |
T |
C |
7: 85,606,782 (GRCm39) |
D188G |
probably benign |
Het |
| Vwa5b2 |
A |
G |
16: 20,415,079 (GRCm39) |
K367R |
probably damaging |
Het |
| Washc4 |
T |
A |
10: 83,410,407 (GRCm39) |
M665K |
possibly damaging |
Het |
| Wbp11 |
T |
A |
6: 136,798,189 (GRCm39) |
Y236F |
probably benign |
Het |
| Wbp4 |
T |
A |
14: 79,709,801 (GRCm39) |
I145F |
possibly damaging |
Het |
| Wwc2 |
C |
A |
8: 48,373,636 (GRCm39) |
D77Y |
probably damaging |
Het |
| Zpld2 |
G |
A |
4: 133,929,459 (GRCm39) |
A282V |
probably benign |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,193,846 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,172,643 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,186,059 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,194,284 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,185,900 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,175,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,187,124 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,177,159 (GRCm39) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,173,312 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,185,963 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,192,427 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,172,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,193,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Tet2
|
UTSW |
3 |
133,173,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,173,045 (GRCm39) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,173,945 (GRCm39) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,173,231 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,182,362 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,182,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,179,406 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,175,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,191,641 (GRCm39) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,172,613 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1727:Tet2
|
UTSW |
3 |
133,193,051 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1738:Tet2
|
UTSW |
3 |
133,187,148 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,185,892 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,187,202 (GRCm39) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,193,094 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1937:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1939:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1940:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,192,350 (GRCm39) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,191,488 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,193,528 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,192,362 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,192,100 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,192,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,172,592 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,185,124 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,175,238 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,191,816 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,193,418 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,191,324 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,191,310 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4647:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,191,844 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,173,076 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,182,381 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,172,805 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,192,520 (GRCm39) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,193,140 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,192,667 (GRCm39) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,182,326 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,191,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,182,241 (GRCm39) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,193,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,192,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,192,860 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,193,721 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,194,296 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,172,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,177,196 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,193,520 (GRCm39) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,186,087 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,192,178 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,193,096 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,185,102 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,188,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,172,784 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,175,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,179,391 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,192,953 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,186,050 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,193,100 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,185,990 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,172,509 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,192,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,192,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,186,056 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,192,302 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,179,404 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,193,426 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,173,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,172,895 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,193,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,194,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8962:Tet2
|
UTSW |
3 |
133,193,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9009:Tet2
|
UTSW |
3 |
133,193,360 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,172,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,175,374 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,173,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,187,147 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,175,115 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,192,903 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,191,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,193,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,173,689 (GRCm39) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,191,566 (GRCm39) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,193,767 (GRCm39) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,193,064 (GRCm39) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,191,803 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,192,056 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,194,134 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAAATTGATCTGCGCTGAGG -3'
(R):5'- ACGGTAAAAGCAGCCGTCAG -3'
Sequencing Primer
(F):5'- ATCTGCGCTGAGGTAAGC -3'
(R):5'- GCCAAATGTCTCCGGACTAAGTG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation