Incidental Mutation 'R4738:Ovgp1'
| ID |
359409 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ovgp1
|
| Ensembl Gene |
ENSMUSG00000074340 |
| Gene Name |
oviductal glycoprotein 1 |
| Synonyms |
oviductin, Chit5, OGP, muc9, MOGP, mucin 9 |
| MMRRC Submission |
041964-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4738 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
105881118-105894739 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 105887234 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 210
(V210A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000000573
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000573]
[ENSMUST00000163626]
|
| AlphaFold |
Q62010 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000000573
AA Change: V210A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: V210A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
13 |
N/A |
INTRINSIC |
|
Glyco_18
|
22 |
360 |
1.38e-134 |
SMART |
|
low complexity region
|
486 |
515 |
N/A |
INTRINSIC |
|
low complexity region
|
533 |
626 |
N/A |
INTRINSIC |
|
low complexity region
|
637 |
648 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000092878
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137168
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163626
|
| SMART Domains |
Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340
| Domain | Start | End | E-Value | Type |
|---|
|
Glyco_18
|
9 |
226 |
8.52e-21 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164055
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167642
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg3 |
A |
G |
5: 105,121,849 (GRCm39) |
I176T |
probably benign |
Het |
| Abtb3 |
C |
T |
10: 85,463,112 (GRCm39) |
Q626* |
probably null |
Het |
| Angpt2 |
C |
T |
8: 18,791,075 (GRCm39) |
D74N |
probably benign |
Het |
| Apol10a |
C |
T |
15: 77,372,841 (GRCm39) |
T159I |
possibly damaging |
Het |
| Areg |
T |
C |
5: 91,294,583 (GRCm39) |
I247T |
possibly damaging |
Het |
| Atg16l2 |
A |
G |
7: 100,946,385 (GRCm39) |
L129P |
probably damaging |
Het |
| Atp6v1b2 |
T |
A |
8: 69,556,062 (GRCm39) |
S246T |
probably benign |
Het |
| Atp8b1 |
T |
C |
18: 64,678,251 (GRCm39) |
R882G |
probably benign |
Het |
| Atp9a |
A |
G |
2: 168,510,101 (GRCm39) |
V444A |
probably benign |
Het |
| Babam2 |
T |
A |
5: 32,058,486 (GRCm39) |
Y211N |
probably damaging |
Het |
| Ccdc127 |
T |
G |
13: 74,505,187 (GRCm39) |
|
probably benign |
Het |
| Cep192 |
A |
T |
18: 68,017,901 (GRCm39) |
K2500* |
probably null |
Het |
| Cnot4 |
T |
C |
6: 35,028,311 (GRCm39) |
N435S |
probably benign |
Het |
| Col12a1 |
T |
C |
9: 79,606,564 (GRCm39) |
I620V |
probably damaging |
Het |
| Cyth4 |
G |
A |
15: 78,490,074 (GRCm39) |
M62I |
probably benign |
Het |
| Dbt |
T |
C |
3: 116,332,781 (GRCm39) |
I200T |
probably damaging |
Het |
| Dchs1 |
C |
T |
7: 105,407,880 (GRCm39) |
R1984Q |
probably damaging |
Het |
| Depdc5 |
A |
G |
5: 33,132,666 (GRCm39) |
M1237V |
probably benign |
Het |
| Disp2 |
A |
G |
2: 118,620,807 (GRCm39) |
Y513C |
probably damaging |
Het |
| Dph7 |
T |
C |
2: 24,853,143 (GRCm39) |
S86P |
possibly damaging |
Het |
| Eif3b |
T |
A |
5: 140,415,833 (GRCm39) |
M384K |
probably benign |
Het |
| Emc1 |
G |
T |
4: 139,089,513 (GRCm39) |
G227V |
possibly damaging |
Het |
| Eri2 |
A |
G |
7: 119,386,955 (GRCm39) |
|
probably null |
Het |
| Frzb |
A |
G |
2: 80,254,941 (GRCm39) |
|
probably null |
Het |
| Ganc |
T |
A |
2: 120,283,075 (GRCm39) |
V743D |
probably damaging |
Het |
| Gfpt1 |
C |
A |
6: 87,031,729 (GRCm39) |
|
probably benign |
Het |
| Gm3086 |
A |
T |
12: 70,016,155 (GRCm39) |
|
probably benign |
Het |
| Gsdmc2 |
A |
T |
15: 63,698,650 (GRCm39) |
Y315* |
probably null |
Het |
| Haus6 |
A |
G |
4: 86,518,986 (GRCm39) |
|
probably null |
Het |
| Hhip |
C |
T |
8: 80,719,199 (GRCm39) |
D443N |
probably damaging |
Het |
| Isg15 |
T |
C |
4: 156,284,319 (GRCm39) |
M70V |
probably benign |
Het |
| Kank2 |
T |
C |
9: 21,685,915 (GRCm39) |
N653S |
probably damaging |
Het |
| Klhdc1 |
G |
T |
12: 69,329,907 (GRCm39) |
R345S |
probably benign |
Het |
| Larp7 |
A |
G |
3: 127,339,694 (GRCm39) |
|
probably null |
Het |
| Lgals12 |
A |
G |
19: 7,581,464 (GRCm39) |
V81A |
probably benign |
Het |
| Lhx9 |
A |
G |
1: 138,760,486 (GRCm39) |
L288P |
probably damaging |
Het |
| Mcpt9 |
T |
A |
14: 56,264,456 (GRCm39) |
H213L |
probably damaging |
Het |
| Met |
T |
C |
6: 17,491,540 (GRCm39) |
C101R |
probably damaging |
Het |
| Myo16 |
G |
T |
8: 10,423,527 (GRCm39) |
G288W |
probably damaging |
Het |
| Neb |
A |
C |
2: 52,077,494 (GRCm39) |
S1846A |
probably damaging |
Het |
| Nr3c2 |
T |
C |
8: 77,635,936 (GRCm39) |
S346P |
possibly damaging |
Het |
| Obi1 |
C |
T |
14: 104,747,819 (GRCm39) |
D43N |
probably damaging |
Het |
| Or10h5 |
A |
G |
17: 33,434,784 (GRCm39) |
F178S |
probably benign |
Het |
| Or1e1c |
G |
T |
11: 73,266,176 (GRCm39) |
L200F |
possibly damaging |
Het |
| Or51e1 |
T |
A |
7: 102,359,378 (GRCm39) |
I304N |
probably damaging |
Het |
| Or5h19 |
T |
C |
16: 58,856,558 (GRCm39) |
I181V |
probably benign |
Het |
| Or5p63 |
A |
T |
7: 107,811,201 (GRCm39) |
N178K |
probably damaging |
Het |
| Osbpl10 |
A |
G |
9: 115,045,642 (GRCm39) |
E426G |
probably damaging |
Het |
| Pam |
A |
T |
1: 97,850,857 (GRCm39) |
V167D |
probably damaging |
Het |
| Pappa2 |
T |
C |
1: 158,784,582 (GRCm39) |
R143G |
probably benign |
Het |
| Pbx4 |
C |
T |
8: 70,317,619 (GRCm39) |
T201M |
probably damaging |
Het |
| Pcdhb9 |
T |
C |
18: 37,536,468 (GRCm39) |
C821R |
probably benign |
Het |
| Plekhg3 |
T |
C |
12: 76,623,688 (GRCm39) |
I976T |
probably damaging |
Het |
| Pold1 |
G |
A |
7: 44,190,753 (GRCm39) |
R304C |
probably damaging |
Het |
| Prss38 |
T |
C |
11: 59,263,771 (GRCm39) |
T314A |
probably benign |
Het |
| Psph |
T |
C |
5: 129,846,450 (GRCm39) |
|
probably null |
Het |
| Ptprj |
G |
A |
2: 90,270,987 (GRCm39) |
P1247L |
probably damaging |
Het |
| Rab3gap1 |
A |
G |
1: 127,862,173 (GRCm39) |
E648G |
probably damaging |
Het |
| Ralgds |
A |
G |
2: 28,435,428 (GRCm39) |
E465G |
probably damaging |
Het |
| Rfng |
T |
C |
11: 120,674,790 (GRCm39) |
T67A |
probably damaging |
Het |
| Rps6kl1 |
G |
T |
12: 85,187,161 (GRCm39) |
F181L |
probably benign |
Het |
| Spata46 |
G |
A |
1: 170,139,455 (GRCm39) |
M151I |
possibly damaging |
Het |
| Ssbp1 |
T |
A |
6: 40,454,914 (GRCm39) |
N124K |
probably damaging |
Het |
| Sspo |
C |
T |
6: 48,455,330 (GRCm39) |
A3064V |
possibly damaging |
Het |
| Tbc1d8 |
G |
A |
1: 39,441,959 (GRCm39) |
T211I |
possibly damaging |
Het |
| Tdpoz4 |
T |
C |
3: 93,704,396 (GRCm39) |
I231T |
probably damaging |
Het |
| Tff3 |
G |
A |
17: 31,346,483 (GRCm39) |
P30S |
probably benign |
Het |
| Thg1l |
C |
T |
11: 45,845,018 (GRCm39) |
R18Q |
probably damaging |
Het |
| Tlk2 |
T |
A |
11: 105,147,708 (GRCm39) |
H369Q |
probably benign |
Het |
| Tnfaip8 |
A |
G |
18: 50,223,569 (GRCm39) |
T14A |
probably damaging |
Het |
| Tspan17 |
T |
A |
13: 54,942,877 (GRCm39) |
C116* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,710,890 (GRCm39) |
|
probably benign |
Het |
| Tyr |
T |
C |
7: 87,141,855 (GRCm39) |
Y158C |
probably null |
Het |
| U2af1l4 |
G |
T |
7: 30,262,773 (GRCm39) |
|
probably benign |
Het |
| Ubqlnl |
C |
T |
7: 103,798,925 (GRCm39) |
V191M |
probably benign |
Het |
| Vmn2r86 |
T |
A |
10: 130,282,939 (GRCm39) |
D559V |
probably damaging |
Het |
| Wfikkn2 |
T |
A |
11: 94,129,902 (GRCm39) |
T80S |
probably benign |
Het |
| Zdhhc2 |
T |
A |
8: 40,917,183 (GRCm39) |
|
probably null |
Het |
| Zfp521 |
T |
C |
18: 13,977,111 (GRCm39) |
K1101E |
possibly damaging |
Het |
| Zfp595 |
A |
T |
13: 67,465,229 (GRCm39) |
F345I |
probably benign |
Het |
| Zswim2 |
T |
A |
2: 83,745,739 (GRCm39) |
R566S |
probably benign |
Het |
|
| Other mutations in Ovgp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00973:Ovgp1
|
APN |
3 |
105,888,593 (GRCm39) |
nonsense |
probably null |
|
|
IGL01152:Ovgp1
|
APN |
3 |
105,893,488 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01458:Ovgp1
|
APN |
3 |
105,882,307 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01646:Ovgp1
|
APN |
3 |
105,885,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01768:Ovgp1
|
APN |
3 |
105,888,667 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02712:Ovgp1
|
APN |
3 |
105,893,829 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03065:Ovgp1
|
APN |
3 |
105,893,682 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03140:Ovgp1
|
APN |
3 |
105,887,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03272:Ovgp1
|
APN |
3 |
105,888,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4472001:Ovgp1
|
UTSW |
3 |
105,894,306 (GRCm39) |
missense |
unknown |
|
|
R0277:Ovgp1
|
UTSW |
3 |
105,887,208 (GRCm39) |
intron |
probably benign |
|
|
R0560:Ovgp1
|
UTSW |
3 |
105,893,726 (GRCm39) |
unclassified |
probably benign |
|
|
R0718:Ovgp1
|
UTSW |
3 |
105,882,146 (GRCm39) |
splice site |
probably benign |
|
|
R0743:Ovgp1
|
UTSW |
3 |
105,882,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1362:Ovgp1
|
UTSW |
3 |
105,893,891 (GRCm39) |
unclassified |
probably benign |
|
|
R1556:Ovgp1
|
UTSW |
3 |
105,894,068 (GRCm39) |
unclassified |
probably benign |
|
|
R1776:Ovgp1
|
UTSW |
3 |
105,885,114 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1831:Ovgp1
|
UTSW |
3 |
105,892,384 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1986:Ovgp1
|
UTSW |
3 |
105,882,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Ovgp1
|
UTSW |
3 |
105,894,309 (GRCm39) |
unclassified |
probably benign |
|
|
R2156:Ovgp1
|
UTSW |
3 |
105,885,033 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R2254:Ovgp1
|
UTSW |
3 |
105,894,228 (GRCm39) |
unclassified |
probably benign |
|
|
R2860:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R2861:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R3117:Ovgp1
|
UTSW |
3 |
105,893,768 (GRCm39) |
unclassified |
probably benign |
|
|
R3793:Ovgp1
|
UTSW |
3 |
105,887,487 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3835:Ovgp1
|
UTSW |
3 |
105,893,631 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3894:Ovgp1
|
UTSW |
3 |
105,893,912 (GRCm39) |
unclassified |
probably benign |
|
|
R3894:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R3895:Ovgp1
|
UTSW |
3 |
105,893,912 (GRCm39) |
unclassified |
probably benign |
|
|
R4050:Ovgp1
|
UTSW |
3 |
105,893,912 (GRCm39) |
unclassified |
probably benign |
|
|
R4050:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R4467:Ovgp1
|
UTSW |
3 |
105,885,027 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4611:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R4628:Ovgp1
|
UTSW |
3 |
105,887,639 (GRCm39) |
splice site |
probably null |
|
|
R4944:Ovgp1
|
UTSW |
3 |
105,887,269 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5110:Ovgp1
|
UTSW |
3 |
105,885,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Ovgp1
|
UTSW |
3 |
105,894,387 (GRCm39) |
unclassified |
probably benign |
|
|
R6540:Ovgp1
|
UTSW |
3 |
105,893,897 (GRCm39) |
nonsense |
probably null |
|
|
R6562:Ovgp1
|
UTSW |
3 |
105,887,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6601:Ovgp1
|
UTSW |
3 |
105,893,747 (GRCm39) |
unclassified |
probably benign |
|
|
R6906:Ovgp1
|
UTSW |
3 |
105,894,189 (GRCm39) |
unclassified |
probably benign |
|
|
R7313:Ovgp1
|
UTSW |
3 |
105,894,387 (GRCm39) |
missense |
unknown |
|
|
R7430:Ovgp1
|
UTSW |
3 |
105,893,619 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7430:Ovgp1
|
UTSW |
3 |
105,893,618 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7566:Ovgp1
|
UTSW |
3 |
105,881,626 (GRCm39) |
start gained |
probably benign |
|
|
R7684:Ovgp1
|
UTSW |
3 |
105,887,272 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7805:Ovgp1
|
UTSW |
3 |
105,894,110 (GRCm39) |
missense |
unknown |
|
|
R7820:Ovgp1
|
UTSW |
3 |
105,893,837 (GRCm39) |
unclassified |
probably benign |
|
|
R7919:Ovgp1
|
UTSW |
3 |
105,888,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8039:Ovgp1
|
UTSW |
3 |
105,883,339 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8483:Ovgp1
|
UTSW |
3 |
105,894,311 (GRCm39) |
unclassified |
probably benign |
|
|
R9259:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R9261:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R9262:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R9359:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R9389:Ovgp1
|
UTSW |
3 |
105,893,841 (GRCm39) |
unclassified |
probably benign |
|
|
R9390:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R9444:Ovgp1
|
UTSW |
3 |
105,893,841 (GRCm39) |
unclassified |
probably benign |
|
|
R9445:Ovgp1
|
UTSW |
3 |
105,893,883 (GRCm39) |
unclassified |
probably benign |
|
|
R9466:Ovgp1
|
UTSW |
3 |
105,887,484 (GRCm39) |
missense |
|
|
|
R9586:Ovgp1
|
UTSW |
3 |
105,881,138 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1177:Ovgp1
|
UTSW |
3 |
105,894,156 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATACATGGAGCTTGATGCACAG -3'
(R):5'- CATAGCATATGCCTGTAGGTGG -3'
Sequencing Primer
(F):5'- GAGCTTGATGCACAGCTATTTCTAGC -3'
(R):5'- CCTGTAGGTGGAAAGAAGATAGCCTC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation