Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03140:Ovgp1'

410676

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ovgp1

Ensembl Gene

ENSMUSG00000074340

Gene Name

oviductal glycoprotein 1

Synonyms

oviductin, Chit5, OGP, muc9, MOGP, mucin 9

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03140

Quality Score

Status

Chromosome

Chromosomal Location

105881118-105894739 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 105887222 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 206 (D206G)

Ref Sequence

ENSEMBL: ENSMUSP00000000573 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]

AlphaFold

Q62010

Predicted Effect

probably damaging
Transcript: ENSMUST00000000573
AA Change: D206G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: D206G

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Glyco_18	22	360	1.38e-134	SMART
low complexity region	486	515	N/A	INTRINSIC
low complexity region	533	626	N/A	INTRINSIC
low complexity region	637	648	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000092878

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137168

Predicted Effect

probably benign
Transcript: ENSMUST00000163626

SMART Domains

Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340

Domain	Start	End	E-Value	Type
Glyco_18	9	226	8.52e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164055

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000167642

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	G	A	19: 8,982,576 (GRCm39)		probably benign	Het
Cd48	T	C	1: 171,523,451 (GRCm39)	V98A	probably damaging	Het
Chd9	A	T	8: 91,768,856 (GRCm39)	R2485S	possibly damaging	Het
Clec4a2	T	C	6: 123,117,735 (GRCm39)		probably benign	Het
Ddx21	A	G	10: 62,429,850 (GRCm39)	L298S	probably damaging	Het
Efl1	A	G	7: 82,342,089 (GRCm39)	E499G	probably benign	Het
Fry	A	G	5: 150,419,166 (GRCm39)	N2870S	probably damaging	Het
Ints8	G	A	4: 11,235,565 (GRCm39)	P355S	probably damaging	Het
Kmo	T	A	1: 175,476,786 (GRCm39)	V200D	probably damaging	Het
Ldlrad4	A	G	18: 68,387,585 (GRCm39)	D299G	probably damaging	Het
Mus81	T	C	19: 5,533,984 (GRCm39)	T416A	probably damaging	Het
Nlrp6	T	C	7: 140,507,400 (GRCm39)	S889P	probably benign	Het
Nlrp9c	T	A	7: 26,079,914 (GRCm39)	D704V	probably benign	Het
Olfml2a	A	G	2: 38,837,303 (GRCm39)	K149E	probably damaging	Het
Pcdhb3	T	G	18: 37,434,272 (GRCm39)	H79Q	probably benign	Het
Pira13	T	C	7: 3,826,247 (GRCm39)	N249D	probably benign	Het
Rnf19b	T	A	4: 128,977,889 (GRCm39)	V701D	probably benign	Het
Setd2	T	C	9: 110,444,020 (GRCm39)		probably null	Het
Ubr3	A	G	2: 69,800,533 (GRCm39)	Y952C	probably damaging	Het
Vmn1r205	T	C	13: 22,776,746 (GRCm39)	I119V	possibly damaging	Het
Zfhx4	T	G	3: 5,307,585 (GRCm39)	D270E	probably damaging	Het

Other mutations in Ovgp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Ovgp1	APN	3	105,888,593 (GRCm39)	nonsense	probably null
IGL01152:Ovgp1	APN	3	105,893,488 (GRCm39)	missense	possibly damaging	0.94
IGL01458:Ovgp1	APN	3	105,882,307 (GRCm39)	missense	probably benign	0.01
IGL01646:Ovgp1	APN	3	105,885,665 (GRCm39)	missense	probably damaging	1.00
IGL01768:Ovgp1	APN	3	105,888,667 (GRCm39)	critical splice donor site	probably null
IGL02712:Ovgp1	APN	3	105,893,829 (GRCm39)	unclassified	probably benign
IGL03065:Ovgp1	APN	3	105,893,682 (GRCm39)	missense	probably benign	0.01
IGL03272:Ovgp1	APN	3	105,888,641 (GRCm39)	missense	probably damaging	0.99
PIT4472001:Ovgp1	UTSW	3	105,894,306 (GRCm39)	missense	unknown
R0277:Ovgp1	UTSW	3	105,887,208 (GRCm39)	intron	probably benign
R0560:Ovgp1	UTSW	3	105,893,726 (GRCm39)	unclassified	probably benign
R0718:Ovgp1	UTSW	3	105,882,146 (GRCm39)	splice site	probably benign
R0743:Ovgp1	UTSW	3	105,882,248 (GRCm39)	missense	probably damaging	1.00
R1362:Ovgp1	UTSW	3	105,893,891 (GRCm39)	unclassified	probably benign
R1556:Ovgp1	UTSW	3	105,894,068 (GRCm39)	unclassified	probably benign
R1776:Ovgp1	UTSW	3	105,885,114 (GRCm39)	missense	possibly damaging	0.52
R1831:Ovgp1	UTSW	3	105,892,384 (GRCm39)	missense	probably benign	0.04
R1986:Ovgp1	UTSW	3	105,882,251 (GRCm39)	missense	probably damaging	1.00
R2004:Ovgp1	UTSW	3	105,894,309 (GRCm39)	unclassified	probably benign
R2156:Ovgp1	UTSW	3	105,885,033 (GRCm39)	missense	possibly damaging	0.49
R2254:Ovgp1	UTSW	3	105,894,228 (GRCm39)	unclassified	probably benign
R2860:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R2861:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R3117:Ovgp1	UTSW	3	105,893,768 (GRCm39)	unclassified	probably benign
R3793:Ovgp1	UTSW	3	105,887,487 (GRCm39)	missense	probably benign	0.03
R3835:Ovgp1	UTSW	3	105,893,631 (GRCm39)	missense	probably benign	0.00
R3894:Ovgp1	UTSW	3	105,893,912 (GRCm39)	unclassified	probably benign
R3894:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R3895:Ovgp1	UTSW	3	105,893,912 (GRCm39)	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105,893,912 (GRCm39)	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R4467:Ovgp1	UTSW	3	105,885,027 (GRCm39)	missense	probably benign	0.04
R4611:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R4628:Ovgp1	UTSW	3	105,887,639 (GRCm39)	splice site	probably null
R4738:Ovgp1	UTSW	3	105,887,234 (GRCm39)	missense	probably damaging	1.00
R4944:Ovgp1	UTSW	3	105,887,269 (GRCm39)	missense	possibly damaging	0.66
R5110:Ovgp1	UTSW	3	105,885,099 (GRCm39)	missense	probably damaging	1.00
R6531:Ovgp1	UTSW	3	105,894,387 (GRCm39)	unclassified	probably benign
R6540:Ovgp1	UTSW	3	105,893,897 (GRCm39)	nonsense	probably null
R6562:Ovgp1	UTSW	3	105,887,589 (GRCm39)	missense	probably damaging	1.00
R6601:Ovgp1	UTSW	3	105,893,747 (GRCm39)	unclassified	probably benign
R6906:Ovgp1	UTSW	3	105,894,189 (GRCm39)	unclassified	probably benign
R7313:Ovgp1	UTSW	3	105,894,387 (GRCm39)	missense	unknown
R7430:Ovgp1	UTSW	3	105,893,619 (GRCm39)	missense	possibly damaging	0.62
R7430:Ovgp1	UTSW	3	105,893,618 (GRCm39)	missense	probably damaging	0.99
R7566:Ovgp1	UTSW	3	105,881,626 (GRCm39)	start gained	probably benign
R7684:Ovgp1	UTSW	3	105,887,272 (GRCm39)	missense	probably damaging	0.99
R7805:Ovgp1	UTSW	3	105,894,110 (GRCm39)	missense	unknown
R7820:Ovgp1	UTSW	3	105,893,837 (GRCm39)	unclassified	probably benign
R7919:Ovgp1	UTSW	3	105,888,601 (GRCm39)	missense	probably damaging	1.00
R8039:Ovgp1	UTSW	3	105,883,339 (GRCm39)	missense	probably benign	0.26
R8483:Ovgp1	UTSW	3	105,894,311 (GRCm39)	unclassified	probably benign
R9259:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R9261:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R9262:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R9359:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R9389:Ovgp1	UTSW	3	105,893,841 (GRCm39)	unclassified	probably benign
R9390:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R9444:Ovgp1	UTSW	3	105,893,841 (GRCm39)	unclassified	probably benign
R9445:Ovgp1	UTSW	3	105,893,883 (GRCm39)	unclassified	probably benign
R9466:Ovgp1	UTSW	3	105,887,484 (GRCm39)	missense
R9586:Ovgp1	UTSW	3	105,881,138 (GRCm39)	missense	probably damaging	0.96
Z1177:Ovgp1	UTSW	3	105,894,156 (GRCm39)	missense	unknown

Posted On

2016-08-02