Incidental Mutation 'IGL02878:Setd3'
ID362727
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Setd3
Ensembl Gene ENSMUSG00000056770
Gene NameSET domain containing 3
Synonyms2610305M23Rik, 2610102I01Rik, D12Ertd771e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02878
Quality Score
Status
Chromosome12
Chromosomal Location108106431-108179314 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 108108555 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000066413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071095] [ENSMUST00000132682]
Predicted Effect probably null
Transcript: ENSMUST00000071095
SMART Domains Protein: ENSMUSP00000066413
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
Pfam:SET 105 314 2.1e-12 PFAM
Pfam:Rubis-subs-bind 345 475 3.7e-31 PFAM
low complexity region 565 577 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125210
Predicted Effect probably benign
Transcript: ENSMUST00000132682
SMART Domains Protein: ENSMUSP00000123159
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
PDB:3SMT|A 2 58 3e-30 PDB
SCOP:d1epua_ 50 79 6e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148119
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,138,329 D801G probably benign Het
Abce1 T C 8: 79,703,007 H95R possibly damaging Het
Axl T A 7: 25,758,877 M818L probably damaging Het
Cckbr C T 7: 105,434,031 A147V probably damaging Het
Cdc40 T C 10: 40,843,122 D337G probably damaging Het
Cep70 T C 9: 99,281,107 probably benign Het
Cpeb1 C T 7: 81,357,326 V318I probably damaging Het
Crlf1 G A 8: 70,503,640 probably null Het
Dnah6 A T 6: 73,032,587 D3740E probably benign Het
Dnajc28 C T 16: 91,616,441 R329Q possibly damaging Het
Ehmt2 T C 17: 34,910,767 Y946H probably damaging Het
Gapdhs C T 7: 30,729,879 probably benign Het
Gpr61 A T 3: 108,150,028 L439H probably damaging Het
Klf9 G T 19: 23,142,269 probably benign Het
Krt73 T C 15: 101,798,826 Y309C probably damaging Het
Lrrk1 T C 7: 66,262,563 M1750V probably benign Het
Mc1r G T 8: 123,407,630 G41C probably damaging Het
Mecr C A 4: 131,854,708 A133E probably damaging Het
Mon2 T C 10: 123,006,991 N1511S probably benign Het
Mrpl13 A T 15: 55,540,199 L106* probably null Het
Mrpl48 A T 7: 100,574,513 V1E possibly damaging Het
Myo1c T A 11: 75,669,033 W683R possibly damaging Het
Myo9a G A 9: 59,908,300 probably null Het
Myrfl A T 10: 116,777,405 I831K possibly damaging Het
Neurl4 T A 11: 69,906,831 Y671N probably damaging Het
Olfr347 A T 2: 36,734,477 D52V probably damaging Het
Olfr57 G T 10: 79,035,558 C254F probably benign Het
Opalin A T 19: 41,067,669 D62E probably benign Het
Otoa T C 7: 121,143,853 F768L probably damaging Het
Pde4b T A 4: 102,601,639 N497K probably damaging Het
Plcl2 T A 17: 50,607,355 L464Q probably damaging Het
Rfc3 A G 5: 151,642,914 *357R probably null Het
Ryr2 A G 13: 11,918,319 S89P probably benign Het
Sema3b C T 9: 107,600,993 V398I probably damaging Het
Sgsh T C 11: 119,346,558 D410G probably damaging Het
Slc9a3 G T 13: 74,165,357 E730* probably null Het
Sptb A G 12: 76,620,753 S857P probably benign Het
Tmem132c T C 5: 127,563,090 L775P probably damaging Het
Togaram1 T C 12: 64,992,626 V1158A possibly damaging Het
Ttn A G 2: 76,776,878 F17934L probably damaging Het
Ube3b T C 5: 114,404,717 probably null Het
Ydjc A G 16: 17,147,605 E111G possibly damaging Het
Zp3r T A 1: 130,582,851 H443L probably benign Het
Other mutations in Setd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Setd3 APN 12 108160237 missense probably damaging 1.00
IGL01365:Setd3 APN 12 108157906 missense probably damaging 1.00
IGL02031:Setd3 APN 12 108163030 missense probably damaging 1.00
IGL02826:Setd3 APN 12 108112124 unclassified probably benign
IGL03039:Setd3 APN 12 108162970 splice site probably null
R0332:Setd3 UTSW 12 108107579 missense probably benign
R1644:Setd3 UTSW 12 108113344 missense possibly damaging 0.88
R1776:Setd3 UTSW 12 108165161 missense probably damaging 1.00
R2018:Setd3 UTSW 12 108118254 missense probably damaging 1.00
R2025:Setd3 UTSW 12 108160267 missense probably damaging 1.00
R2041:Setd3 UTSW 12 108113392 missense possibly damaging 0.84
R2058:Setd3 UTSW 12 108107341 missense probably benign 0.03
R2206:Setd3 UTSW 12 108107285 missense probably benign 0.11
R2207:Setd3 UTSW 12 108107285 missense probably benign 0.11
R3973:Setd3 UTSW 12 108165158 missense possibly damaging 0.93
R3976:Setd3 UTSW 12 108165158 missense possibly damaging 0.93
R3978:Setd3 UTSW 12 108157942 missense possibly damaging 0.63
R4684:Setd3 UTSW 12 108108690 missense probably benign 0.05
R4965:Setd3 UTSW 12 108113371 missense probably benign 0.29
R5691:Setd3 UTSW 12 108160285 missense probably benign 0.19
R5990:Setd3 UTSW 12 108160335 missense probably benign
R6198:Setd3 UTSW 12 108165168 missense possibly damaging 0.66
R6241:Setd3 UTSW 12 108157855 missense probably benign 0.24
R6428:Setd3 UTSW 12 108113338 missense probably damaging 0.99
X0052:Setd3 UTSW 12 108107665 missense probably benign 0.37
Posted On2015-12-18