Incidental Mutation 'IGL02884:Wee1'
ID |
362936 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Wee1
|
Ensembl Gene |
ENSMUSG00000031016 |
Gene Name |
WEE 1 homolog 1 (S. pombe) |
Synonyms |
Wee1A |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL02884
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
109721266-109742506 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 109725269 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Valine
at position 304
(I304V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000033326
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033326]
|
AlphaFold |
P47810 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000033326
AA Change: I304V
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
SMART Domains |
Protein: ENSMUSP00000033326 Gene: ENSMUSG00000031016 AA Change: I304V
Domain | Start | End | E-Value | Type |
low complexity region
|
62 |
112 |
N/A |
INTRINSIC |
Pfam:Pkinase_Tyr
|
298 |
566 |
1.9e-26 |
PFAM |
Pfam:Pkinase
|
298 |
568 |
1.7e-61 |
PFAM |
low complexity region
|
620 |
631 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185931
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210940
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 53 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930438A08Rik |
A |
G |
11: 58,178,302 (GRCm39) |
I121V |
probably benign |
Het |
Adprh |
C |
T |
16: 38,266,396 (GRCm39) |
V249I |
probably benign |
Het |
Akap11 |
A |
T |
14: 78,736,402 (GRCm39) |
M1797K |
probably benign |
Het |
Akap6 |
T |
A |
12: 52,933,405 (GRCm39) |
I299N |
probably benign |
Het |
Akr1c12 |
A |
T |
13: 4,322,211 (GRCm39) |
M277K |
possibly damaging |
Het |
Ankrd17 |
A |
T |
5: 90,412,616 (GRCm39) |
M1236K |
probably damaging |
Het |
Arhgef11 |
A |
G |
3: 87,635,313 (GRCm39) |
D874G |
probably damaging |
Het |
Atg4b |
T |
C |
1: 93,715,437 (GRCm39) |
|
probably benign |
Het |
Bcl9 |
G |
A |
3: 97,117,368 (GRCm39) |
P442L |
probably damaging |
Het |
Ccdc107 |
A |
T |
4: 43,495,228 (GRCm39) |
K98* |
probably null |
Het |
Cenpl |
A |
G |
1: 160,913,619 (GRCm39) |
Q343R |
probably benign |
Het |
Cep104 |
T |
C |
4: 154,074,319 (GRCm39) |
C524R |
probably damaging |
Het |
Clec3b |
C |
T |
9: 122,985,827 (GRCm39) |
T75I |
probably benign |
Het |
Col13a1 |
A |
T |
10: 61,741,064 (GRCm39) |
|
probably benign |
Het |
Crot |
C |
T |
5: 9,028,197 (GRCm39) |
|
probably null |
Het |
Ddo |
G |
A |
10: 40,513,360 (GRCm39) |
V101I |
probably benign |
Het |
Disp2 |
T |
C |
2: 118,618,032 (GRCm39) |
|
probably benign |
Het |
Dnmt3b |
A |
C |
2: 153,516,297 (GRCm39) |
Y474S |
probably damaging |
Het |
Dpp6 |
T |
A |
5: 27,839,554 (GRCm39) |
N298K |
possibly damaging |
Het |
Fbf1 |
C |
T |
11: 116,037,339 (GRCm39) |
E940K |
probably damaging |
Het |
Fgd6 |
A |
G |
10: 93,881,501 (GRCm39) |
|
probably benign |
Het |
H2-M10.2 |
T |
C |
17: 36,595,568 (GRCm39) |
R241G |
probably damaging |
Het |
Haghl |
A |
T |
17: 26,002,072 (GRCm39) |
F207Y |
possibly damaging |
Het |
Helt |
G |
A |
8: 46,745,620 (GRCm39) |
R88C |
probably damaging |
Het |
Igf2bp2 |
T |
C |
16: 21,981,635 (GRCm39) |
K27E |
probably benign |
Het |
Il1b |
T |
C |
2: 129,207,022 (GRCm39) |
H246R |
probably benign |
Het |
Itprid1 |
T |
C |
6: 55,851,339 (GRCm39) |
|
probably null |
Het |
Kcnu1 |
C |
T |
8: 26,411,556 (GRCm39) |
S167L |
probably damaging |
Het |
Kif16b |
A |
T |
2: 142,544,534 (GRCm39) |
|
probably benign |
Het |
Myh7 |
A |
T |
14: 55,230,276 (GRCm39) |
S19T |
probably benign |
Het |
Ncaph2 |
T |
C |
15: 89,248,447 (GRCm39) |
|
probably null |
Het |
Nlrp4c |
T |
C |
7: 6,101,951 (GRCm39) |
L879P |
probably damaging |
Het |
Nqo2 |
T |
A |
13: 34,156,344 (GRCm39) |
N19K |
probably damaging |
Het |
Or2r2 |
C |
T |
6: 42,463,540 (GRCm39) |
V196M |
probably damaging |
Het |
Osbpl1a |
C |
A |
18: 12,952,635 (GRCm39) |
G93* |
probably null |
Het |
Pdxdc1 |
A |
G |
16: 13,661,659 (GRCm39) |
F459L |
possibly damaging |
Het |
Phc2 |
A |
T |
4: 128,601,809 (GRCm39) |
H88L |
probably damaging |
Het |
Pkd1l2 |
G |
A |
8: 117,792,484 (GRCm39) |
T436I |
probably benign |
Het |
Ptchd4 |
A |
T |
17: 42,813,340 (GRCm39) |
T414S |
possibly damaging |
Het |
Rab7b |
A |
G |
1: 131,626,280 (GRCm39) |
R103G |
probably damaging |
Het |
Retnla |
A |
G |
16: 48,662,943 (GRCm39) |
Y3C |
probably benign |
Het |
Samd7 |
G |
A |
3: 30,810,322 (GRCm39) |
R113H |
probably damaging |
Het |
Shisa9 |
G |
A |
16: 11,814,907 (GRCm39) |
|
probably benign |
Het |
Soat1 |
A |
T |
1: 156,268,926 (GRCm39) |
I208N |
possibly damaging |
Het |
Stab1 |
C |
A |
14: 30,872,100 (GRCm39) |
|
probably null |
Het |
Tti2 |
C |
T |
8: 31,641,505 (GRCm39) |
L210F |
possibly damaging |
Het |
Ube2v2 |
A |
G |
16: 15,374,349 (GRCm39) |
V77A |
probably benign |
Het |
Ubr5 |
T |
C |
15: 37,998,620 (GRCm39) |
E1617G |
probably damaging |
Het |
Vmn2r16 |
T |
A |
5: 109,508,757 (GRCm39) |
I495K |
possibly damaging |
Het |
Vwce |
G |
T |
19: 10,623,943 (GRCm39) |
R278L |
possibly damaging |
Het |
Wdr26 |
C |
T |
1: 181,010,349 (GRCm39) |
A551T |
probably damaging |
Het |
Xrcc5 |
C |
T |
1: 72,385,396 (GRCm39) |
H496Y |
possibly damaging |
Het |
Zfp142 |
G |
T |
1: 74,611,142 (GRCm39) |
S884R |
probably damaging |
Het |
|
Other mutations in Wee1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00693:Wee1
|
APN |
7 |
109,734,060 (GRCm39) |
splice site |
probably null |
|
IGL00981:Wee1
|
APN |
7 |
109,738,876 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01017:Wee1
|
APN |
7 |
109,725,055 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01357:Wee1
|
APN |
7 |
109,741,242 (GRCm39) |
missense |
probably benign |
0.39 |
IGL01838:Wee1
|
APN |
7 |
109,723,744 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01970:Wee1
|
APN |
7 |
109,738,457 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02396:Wee1
|
APN |
7 |
109,741,300 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02511:Wee1
|
APN |
7 |
109,738,483 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL03085:Wee1
|
APN |
7 |
109,723,805 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03221:Wee1
|
APN |
7 |
109,726,024 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03383:Wee1
|
APN |
7 |
109,738,899 (GRCm39) |
missense |
probably damaging |
1.00 |
R0220:Wee1
|
UTSW |
7 |
109,723,733 (GRCm39) |
missense |
probably benign |
0.10 |
R1934:Wee1
|
UTSW |
7 |
109,721,698 (GRCm39) |
missense |
probably benign |
0.06 |
R3110:Wee1
|
UTSW |
7 |
109,730,043 (GRCm39) |
missense |
probably damaging |
1.00 |
R3112:Wee1
|
UTSW |
7 |
109,730,043 (GRCm39) |
missense |
probably damaging |
1.00 |
R3978:Wee1
|
UTSW |
7 |
109,723,762 (GRCm39) |
missense |
probably damaging |
1.00 |
R4348:Wee1
|
UTSW |
7 |
109,730,165 (GRCm39) |
missense |
probably damaging |
1.00 |
R5434:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5435:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5436:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5449:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5566:Wee1
|
UTSW |
7 |
109,725,257 (GRCm39) |
nonsense |
probably null |
|
R5630:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5632:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5685:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5694:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5807:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R5941:Wee1
|
UTSW |
7 |
109,723,776 (GRCm39) |
frame shift |
probably null |
|
R6044:Wee1
|
UTSW |
7 |
109,738,513 (GRCm39) |
missense |
probably benign |
0.00 |
R6163:Wee1
|
UTSW |
7 |
109,734,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R6826:Wee1
|
UTSW |
7 |
109,723,870 (GRCm39) |
critical splice donor site |
probably null |
|
R7203:Wee1
|
UTSW |
7 |
109,734,001 (GRCm39) |
missense |
probably benign |
0.00 |
R7835:Wee1
|
UTSW |
7 |
109,730,085 (GRCm39) |
nonsense |
probably null |
|
R8273:Wee1
|
UTSW |
7 |
109,723,691 (GRCm39) |
missense |
probably benign |
0.00 |
R8953:Wee1
|
UTSW |
7 |
109,723,691 (GRCm39) |
missense |
probably benign |
0.00 |
R9077:Wee1
|
UTSW |
7 |
109,725,963 (GRCm39) |
missense |
probably damaging |
1.00 |
R9336:Wee1
|
UTSW |
7 |
109,721,689 (GRCm39) |
missense |
probably damaging |
1.00 |
R9463:Wee1
|
UTSW |
7 |
109,721,917 (GRCm39) |
missense |
probably damaging |
1.00 |
R9673:Wee1
|
UTSW |
7 |
109,725,210 (GRCm39) |
missense |
probably damaging |
0.98 |
R9748:Wee1
|
UTSW |
7 |
109,721,722 (GRCm39) |
nonsense |
probably null |
|
|
Posted On |
2015-12-18 |