Incidental Mutation 'R5033:Map4k4'
| ID |
389315 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4k4
|
| Ensembl Gene |
ENSMUSG00000026074 |
| Gene Name |
mitogen-activated protein kinase kinase kinase kinase 4 |
| Synonyms |
9430080K19Rik, Nik |
| MMRRC Submission |
042624-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5033 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
39940073-40065470 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 40046662 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 646
(K646R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141862
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163854]
[ENSMUST00000168431]
[ENSMUST00000191964]
[ENSMUST00000192509]
[ENSMUST00000193682]
[ENSMUST00000195259]
[ENSMUST00000195636]
[ENSMUST00000195860]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163854
AA Change: K777R
PolyPhen 2
Score 0.128 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000126961
Gene: ENSMUSG00000026074
AA Change: K777R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000168431
AA Change: K730R
|
| SMART Domains |
Protein: ENSMUSP00000129796
Gene: ENSMUSG00000026074
AA Change: K730R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191865
AA Change: K134R
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191964
|
| SMART Domains |
Protein: ENSMUSP00000141235
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
SCOP:d1i7qa_
|
35 |
139 |
7e-3 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192194
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192355
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000192509
AA Change: K723R
|
| SMART Domains |
Protein: ENSMUSP00000141665
Gene: ENSMUSG00000026074
AA Change: K723R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000193682
AA Change: K646R
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000141862
Gene: ENSMUSG00000026074
AA Change: K646R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
590 |
616 |
N/A |
INTRINSIC |
|
low complexity region
|
623 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
680 |
706 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
862 |
N/A |
INTRINSIC |
|
CNH
|
903 |
1201 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195259
AA Change: K700R
|
| SMART Domains |
Protein: ENSMUSP00000142056
Gene: ENSMUSG00000026074
AA Change: K700R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
824 |
N/A |
INTRINSIC |
|
low complexity region
|
839 |
849 |
N/A |
INTRINSIC |
|
CNH
|
890 |
1188 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195636
AA Change: K700R
|
| SMART Domains |
Protein: ENSMUSP00000141613
Gene: ENSMUSG00000026074
AA Change: K700R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
913 |
N/A |
INTRINSIC |
|
CNH
|
954 |
1252 |
1.4e-129 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195860
AA Change: K777R
PolyPhen 2
Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000141400
Gene: ENSMUSG00000026074
AA Change: K777R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
G |
T |
11: 109,684,980 (GRCm39) |
C172* |
probably null |
Het |
| 9930111J21Rik1 |
G |
A |
11: 48,838,533 (GRCm39) |
R685W |
probably damaging |
Het |
| Arhgap10 |
A |
T |
8: 78,109,386 (GRCm39) |
L399H |
probably damaging |
Het |
| Arih2 |
AGCCG |
AG |
9: 108,488,859 (GRCm39) |
|
probably benign |
Het |
| Atp13a2 |
A |
G |
4: 140,728,132 (GRCm39) |
H575R |
possibly damaging |
Het |
| Bbof1 |
G |
A |
12: 84,458,044 (GRCm39) |
|
probably null |
Het |
| Bltp3a |
A |
G |
17: 28,105,838 (GRCm39) |
E788G |
probably damaging |
Het |
| Catsperg2 |
A |
C |
7: 29,409,559 (GRCm39) |
Y545D |
possibly damaging |
Het |
| Cdc42bpa |
T |
A |
1: 179,892,580 (GRCm39) |
I248N |
probably damaging |
Het |
| Cdk11b |
A |
T |
4: 155,733,282 (GRCm39) |
|
probably benign |
Het |
| Cfap46 |
C |
A |
7: 139,183,776 (GRCm39) |
L90F |
probably benign |
Het |
| Cndp2 |
A |
G |
18: 84,688,954 (GRCm39) |
L276P |
possibly damaging |
Het |
| Col3a1 |
A |
C |
1: 45,385,270 (GRCm39) |
D129A |
probably damaging |
Het |
| Daam1 |
C |
A |
12: 71,993,294 (GRCm39) |
H354Q |
unknown |
Het |
| Dnah5 |
T |
A |
15: 28,421,824 (GRCm39) |
F3892Y |
probably damaging |
Het |
| Dnajb3 |
A |
G |
1: 88,132,745 (GRCm39) |
V219A |
possibly damaging |
Het |
| Drd5 |
A |
G |
5: 38,477,544 (GRCm39) |
H179R |
probably damaging |
Het |
| Dym |
A |
G |
18: 75,252,232 (GRCm39) |
N333D |
possibly damaging |
Het |
| Eif2b3 |
A |
G |
4: 116,909,933 (GRCm39) |
D156G |
probably damaging |
Het |
| Emc1 |
A |
G |
4: 139,099,007 (GRCm39) |
D830G |
probably damaging |
Het |
| F13a1 |
A |
C |
13: 37,172,830 (GRCm39) |
I183M |
probably damaging |
Het |
| Fam136b-ps |
T |
A |
15: 31,277,043 (GRCm39) |
|
probably benign |
Het |
| Fdft1 |
C |
A |
14: 63,400,853 (GRCm39) |
K93N |
probably damaging |
Het |
| Garre1 |
C |
T |
7: 33,945,237 (GRCm39) |
G336S |
probably benign |
Het |
| Gcc2 |
A |
G |
10: 58,114,628 (GRCm39) |
D959G |
probably damaging |
Het |
| Gp2 |
A |
G |
7: 119,053,514 (GRCm39) |
V149A |
probably damaging |
Het |
| Gpc1 |
G |
A |
1: 92,784,751 (GRCm39) |
G308D |
probably damaging |
Het |
| Hdac9 |
A |
T |
12: 34,423,906 (GRCm39) |
C587S |
probably benign |
Het |
| Hspg2 |
C |
T |
4: 137,246,251 (GRCm39) |
R1010C |
probably damaging |
Het |
| Iars2 |
A |
G |
1: 185,050,125 (GRCm39) |
V453A |
possibly damaging |
Het |
| Il1r1 |
T |
G |
1: 40,332,684 (GRCm39) |
C121W |
probably damaging |
Het |
| Inhca |
A |
G |
9: 103,156,613 (GRCm39) |
V149A |
probably benign |
Het |
| Jazf1 |
A |
G |
6: 52,754,525 (GRCm39) |
Y184H |
probably damaging |
Het |
| Kel |
A |
T |
6: 41,675,989 (GRCm39) |
Y234N |
probably damaging |
Het |
| Khk |
G |
A |
5: 31,087,004 (GRCm39) |
G186D |
probably damaging |
Het |
| Klf4 |
A |
T |
4: 55,530,301 (GRCm39) |
M270K |
probably benign |
Het |
| Kmt2c |
G |
A |
5: 25,519,706 (GRCm39) |
L2135F |
probably benign |
Het |
| Krtap15-1 |
A |
G |
16: 88,626,044 (GRCm39) |
Y37C |
probably damaging |
Het |
| Lars1 |
A |
G |
18: 42,347,841 (GRCm39) |
F994S |
possibly damaging |
Het |
| Ldc1 |
C |
T |
4: 130,115,408 (GRCm39) |
|
probably null |
Het |
| Lrp8 |
T |
C |
4: 107,691,952 (GRCm39) |
|
probably null |
Het |
| Lrrc2 |
A |
T |
9: 110,809,987 (GRCm39) |
D341V |
probably damaging |
Het |
| Mrps9 |
T |
A |
1: 42,934,491 (GRCm39) |
|
probably null |
Het |
| Or10ag60 |
T |
A |
2: 87,438,055 (GRCm39) |
C108S |
probably damaging |
Het |
| Or11h6 |
T |
A |
14: 50,880,619 (GRCm39) |
Y288N |
probably damaging |
Het |
| Or8c20 |
C |
T |
9: 38,260,924 (GRCm39) |
H176Y |
probably damaging |
Het |
| Pcnt |
A |
T |
10: 76,235,779 (GRCm39) |
C1401S |
possibly damaging |
Het |
| Pdgfrb |
A |
T |
18: 61,210,740 (GRCm39) |
K749M |
probably damaging |
Het |
| Pigo |
A |
T |
4: 43,019,412 (GRCm39) |
W969R |
probably null |
Het |
| Pigr |
A |
T |
1: 130,772,436 (GRCm39) |
Y218F |
probably damaging |
Het |
| Pih1d1 |
A |
G |
7: 44,804,278 (GRCm39) |
|
probably benign |
Het |
| Pik3cg |
A |
T |
12: 32,249,195 (GRCm39) |
|
probably null |
Het |
| Pik3r6 |
A |
T |
11: 68,424,294 (GRCm39) |
K300* |
probably null |
Het |
| Pip5k1c |
A |
G |
10: 81,141,084 (GRCm39) |
D64G |
probably damaging |
Het |
| Piwil2 |
A |
T |
14: 70,659,042 (GRCm39) |
I161K |
possibly damaging |
Het |
| Pou3f1 |
A |
G |
4: 124,552,449 (GRCm39) |
E317G |
probably damaging |
Het |
| Prdm8 |
C |
T |
5: 98,333,071 (GRCm39) |
Q213* |
probably null |
Het |
| Prpf6 |
T |
A |
2: 181,291,899 (GRCm39) |
C739S |
possibly damaging |
Het |
| Psmc3 |
T |
A |
2: 90,884,953 (GRCm39) |
S40T |
probably benign |
Het |
| Psmd3 |
A |
T |
11: 98,573,650 (GRCm39) |
D32V |
probably damaging |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Rapgef6 |
A |
T |
11: 54,582,207 (GRCm39) |
H1373L |
possibly damaging |
Het |
| Rnf207 |
A |
C |
4: 152,397,666 (GRCm39) |
S328A |
probably benign |
Het |
| Ros1 |
C |
T |
10: 52,004,512 (GRCm39) |
|
probably null |
Het |
| Ryr2 |
T |
A |
13: 11,602,140 (GRCm39) |
I4581F |
possibly damaging |
Het |
| Sacm1l |
C |
T |
9: 123,415,464 (GRCm39) |
R480W |
probably damaging |
Het |
| Sec16a |
A |
G |
2: 26,309,661 (GRCm39) |
V664A |
probably benign |
Het |
| Selenoo |
T |
A |
15: 88,976,969 (GRCm39) |
M207K |
probably damaging |
Het |
| Sh3tc2 |
G |
A |
18: 62,147,962 (GRCm39) |
|
probably null |
Het |
| Slc28a2b |
T |
A |
2: 122,353,395 (GRCm39) |
|
probably null |
Het |
| Slco2b1 |
G |
T |
7: 99,309,256 (GRCm39) |
Q692K |
probably benign |
Het |
| Slfn4 |
A |
T |
11: 83,077,623 (GRCm39) |
D137V |
probably damaging |
Het |
| Srrm2 |
G |
A |
17: 24,039,592 (GRCm39) |
A2175T |
probably damaging |
Het |
| Stard9 |
T |
A |
2: 120,523,880 (GRCm39) |
C692S |
probably benign |
Het |
| Sulf2 |
T |
A |
2: 165,923,542 (GRCm39) |
D559V |
probably benign |
Het |
| Tbpl2 |
T |
C |
2: 23,977,170 (GRCm39) |
I283V |
probably benign |
Het |
| Tmem19 |
A |
G |
10: 115,195,666 (GRCm39) |
F46S |
probably benign |
Het |
| Trp63 |
T |
A |
16: 25,582,056 (GRCm39) |
Y35N |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,716,786 (GRCm39) |
|
probably benign |
Het |
| Ube2z |
A |
T |
11: 95,941,148 (GRCm39) |
H331Q |
probably benign |
Het |
| Ubr1 |
C |
T |
2: 120,742,478 (GRCm39) |
|
probably null |
Het |
| Vmn1r235 |
A |
T |
17: 21,482,550 (GRCm39) |
I292F |
possibly damaging |
Het |
| Vmn2r1 |
T |
A |
3: 64,012,501 (GRCm39) |
D787E |
probably damaging |
Het |
| Vmn2r3 |
A |
G |
3: 64,167,220 (GRCm39) |
V637A |
probably benign |
Het |
| Xpnpep1 |
C |
A |
19: 52,994,606 (GRCm39) |
V341L |
probably benign |
Het |
| Yme1l1 |
A |
G |
2: 23,084,759 (GRCm39) |
D619G |
probably damaging |
Het |
| Zfp597 |
G |
A |
16: 3,684,502 (GRCm39) |
P85S |
probably damaging |
Het |
| Zscan20 |
A |
G |
4: 128,479,921 (GRCm39) |
S857P |
probably benign |
Het |
|
| Other mutations in Map4k4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00328:Map4k4
|
APN |
1 |
40,043,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00417:Map4k4
|
APN |
1 |
40,053,692 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00516:Map4k4
|
APN |
1 |
40,053,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01545:Map4k4
|
APN |
1 |
40,053,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02092:Map4k4
|
APN |
1 |
40,063,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02092:Map4k4
|
APN |
1 |
40,025,943 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02570:Map4k4
|
APN |
1 |
40,019,739 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02626:Map4k4
|
APN |
1 |
40,053,257 (GRCm39) |
splice site |
probably benign |
|
|
IGL02993:Map4k4
|
APN |
1 |
40,053,348 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03178:Map4k4
|
APN |
1 |
40,025,853 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
tank
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02835:Map4k4
|
UTSW |
1 |
40,049,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0496:Map4k4
|
UTSW |
1 |
40,045,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0498:Map4k4
|
UTSW |
1 |
40,029,338 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0588:Map4k4
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Map4k4
|
UTSW |
1 |
40,042,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Map4k4
|
UTSW |
1 |
40,043,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Map4k4
|
UTSW |
1 |
40,060,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Map4k4
|
UTSW |
1 |
40,045,990 (GRCm39) |
splice site |
probably benign |
|
|
R1763:Map4k4
|
UTSW |
1 |
40,039,917 (GRCm39) |
splice site |
probably benign |
|
|
R1800:Map4k4
|
UTSW |
1 |
40,062,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1893:Map4k4
|
UTSW |
1 |
40,040,717 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2411:Map4k4
|
UTSW |
1 |
40,046,656 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2851:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2987:Map4k4
|
UTSW |
1 |
40,025,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3087:Map4k4
|
UTSW |
1 |
40,060,242 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3688:Map4k4
|
UTSW |
1 |
40,024,331 (GRCm39) |
splice site |
probably null |
|
|
R4075:Map4k4
|
UTSW |
1 |
40,062,622 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4304:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4564:Map4k4
|
UTSW |
1 |
40,028,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4569:Map4k4
|
UTSW |
1 |
40,039,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4613:Map4k4
|
UTSW |
1 |
40,056,351 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4715:Map4k4
|
UTSW |
1 |
40,058,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Map4k4
|
UTSW |
1 |
40,043,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4926:Map4k4
|
UTSW |
1 |
40,056,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4943:Map4k4
|
UTSW |
1 |
40,058,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5177:Map4k4
|
UTSW |
1 |
40,025,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5297:Map4k4
|
UTSW |
1 |
40,001,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5844:Map4k4
|
UTSW |
1 |
40,039,036 (GRCm39) |
splice site |
probably benign |
|
|
R5952:Map4k4
|
UTSW |
1 |
40,039,082 (GRCm39) |
unclassified |
probably benign |
|
|
R6111:Map4k4
|
UTSW |
1 |
40,050,822 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6125:Map4k4
|
UTSW |
1 |
40,043,125 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6838:Map4k4
|
UTSW |
1 |
40,015,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6927:Map4k4
|
UTSW |
1 |
40,050,842 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7008:Map4k4
|
UTSW |
1 |
40,028,131 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7164:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7195:Map4k4
|
UTSW |
1 |
40,058,829 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7352:Map4k4
|
UTSW |
1 |
40,001,387 (GRCm39) |
missense |
unknown |
|
|
R7589:Map4k4
|
UTSW |
1 |
40,060,251 (GRCm39) |
nonsense |
probably null |
|
|
R7816:Map4k4
|
UTSW |
1 |
40,053,368 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7869:Map4k4
|
UTSW |
1 |
40,013,204 (GRCm39) |
missense |
unknown |
|
|
R8013:Map4k4
|
UTSW |
1 |
40,001,372 (GRCm39) |
missense |
unknown |
|
|
R8145:Map4k4
|
UTSW |
1 |
40,039,694 (GRCm39) |
missense |
|
|
|
R8154:Map4k4
|
UTSW |
1 |
40,060,302 (GRCm39) |
nonsense |
probably null |
|
|
R8254:Map4k4
|
UTSW |
1 |
40,045,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8266:Map4k4
|
UTSW |
1 |
40,050,813 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8375:Map4k4
|
UTSW |
1 |
40,063,801 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8487:Map4k4
|
UTSW |
1 |
40,028,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8699:Map4k4
|
UTSW |
1 |
40,015,910 (GRCm39) |
missense |
unknown |
|
|
R8726:Map4k4
|
UTSW |
1 |
40,043,142 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8907:Map4k4
|
UTSW |
1 |
40,058,770 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8956:Map4k4
|
UTSW |
1 |
40,039,840 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8963:Map4k4
|
UTSW |
1 |
40,039,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9234:Map4k4
|
UTSW |
1 |
40,029,261 (GRCm39) |
missense |
unknown |
|
|
R9270:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9438:Map4k4
|
UTSW |
1 |
40,045,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9689:Map4k4
|
UTSW |
1 |
40,058,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9771:Map4k4
|
UTSW |
1 |
40,025,877 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTCAGACCCTATGGAGAGG -3'
(R):5'- TTCTATTTCCCCACAGCAGG -3'
Sequencing Primer
(F):5'- CCTATGGAGAGGGGTCGACTG -3'
(R):5'- ACCACTGCAGGCCTCTC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation