Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03196:Ncoa7'

412836

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ncoa7

Ensembl Gene

ENSMUSG00000039697

Gene Name

nuclear receptor coactivator 7

Synonyms

9030406N13Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03196

Quality Score

Status

Chromosome

Chromosomal Location

30521578-30683401 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

T to A at 30523510 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150671 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068567] [ENSMUST00000092610] [ENSMUST00000213836] [ENSMUST00000213897] [ENSMUST00000215740] [ENSMUST00000215926] [ENSMUST00000216172] [ENSMUST00000217138] [ENSMUST00000217644]

AlphaFold

Q6DFV7

Predicted Effect

probably benign
Transcript: ENSMUST00000068567

SMART Domains

Protein: ENSMUSP00000066741
Gene: ENSMUSG00000039697

Domain	Start	End	E-Value	Type
coiled coil region	1	32	N/A	INTRINSIC
LysM	118	161	2.24e-7	SMART
low complexity region	165	176	N/A	INTRINSIC
TLDc	781	943	2.86e-64	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000092610

SMART Domains

Protein: ENSMUSP00000090273
Gene: ENSMUSG00000039697

Domain	Start	End	E-Value	Type
TLDc	59	221	2.86e-64	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000213836

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213889

Predicted Effect

probably benign
Transcript: ENSMUST00000213897

Predicted Effect

probably benign
Transcript: ENSMUST00000215740

Predicted Effect

probably benign
Transcript: ENSMUST00000215926

Predicted Effect

probably benign
Transcript: ENSMUST00000216172

Predicted Effect

probably benign
Transcript: ENSMUST00000217138

Predicted Effect

probably benign
Transcript: ENSMUST00000217644

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(108) : Gene trapped(108)

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700003E16Rik	T	C	6: 83,138,045 (GRCm39)	V57A	probably damaging	Het
Adck1	T	C	12: 88,397,885 (GRCm39)	V173A	probably damaging	Het
Adgrv1	C	A	13: 81,594,597 (GRCm39)	R4139L	probably benign	Het
Aqp4	T	G	18: 15,526,566 (GRCm39)	D305A	probably benign	Het
Cadm1	T	C	9: 47,710,675 (GRCm39)	S193P	possibly damaging	Het
Ccdc88a	T	C	11: 29,432,340 (GRCm39)	S377P	possibly damaging	Het
Clic5	C	A	17: 44,552,960 (GRCm39)	H71Q	possibly damaging	Het
Col20a1	G	A	2: 180,649,671 (GRCm39)		probably null	Het
Col5a1	A	G	2: 27,865,610 (GRCm39)	D759G	unknown	Het
Cplane1	A	T	15: 8,230,826 (GRCm39)	K1034N	probably damaging	Het
Cpt1b	A	G	15: 89,308,598 (GRCm39)	V110A	probably benign	Het
Cts8	C	T	13: 61,401,272 (GRCm39)	G85S	probably benign	Het
Cul5	T	A	9: 53,537,180 (GRCm39)	M551L	probably damaging	Het
Eno1b	T	A	18: 48,180,558 (GRCm39)	D245E	probably damaging	Het
Fgf1	A	T	18: 38,975,028 (GRCm39)	Y140*	probably null	Het
Flt1	A	G	5: 147,551,937 (GRCm39)		probably null	Het
Fndc7	A	G	3: 108,790,760 (GRCm39)	Y89H	probably damaging	Het
Gm3127	A	T	14: 15,432,259 (GRCm39)	M254L	probably benign	Het
Gm5849	T	C	3: 90,685,089 (GRCm39)	E32G	probably damaging	Het
Gys1	T	C	7: 45,104,241 (GRCm39)		probably benign	Het
H2ap	A	G	X: 9,713,349 (GRCm39)	Q27R	possibly damaging	Het
Hdgfl2	T	C	17: 56,400,607 (GRCm39)	V125A	probably benign	Het
Igkv6-32	C	T	6: 70,051,042 (GRCm39)	V105I	probably benign	Het
Lmo3	T	C	6: 138,342,993 (GRCm39)	T140A	probably benign	Het
Marf1	A	G	16: 13,958,123 (GRCm39)	V793A	possibly damaging	Het
Mep1b	A	C	18: 21,228,121 (GRCm39)	I575L	probably benign	Het
Mtmr4	T	A	11: 87,491,609 (GRCm39)	I155N	possibly damaging	Het
Muc2	T	C	7: 141,301,367 (GRCm39)	F361L	probably damaging	Het
Nme6	C	T	9: 109,670,561 (GRCm39)	R71W	probably damaging	Het
Or56b1b	T	C	7: 108,164,061 (GRCm39)	S314G	probably benign	Het
Or9g4b	G	A	2: 85,616,365 (GRCm39)	G170D	possibly damaging	Het
Or9m2	A	T	2: 87,820,826 (GRCm39)	I124F	possibly damaging	Het
Osbpl9	C	T	4: 108,930,061 (GRCm39)	V357I	probably damaging	Het
Ppp4r3a	A	G	12: 101,015,913 (GRCm39)		probably benign	Het
Rnf216	T	C	5: 143,066,766 (GRCm39)	R474G	probably damaging	Het
Rpp25l	A	G	4: 41,712,541 (GRCm39)	V78A	possibly damaging	Het
Sh3bp2	C	A	5: 34,714,687 (GRCm39)	P245Q	probably damaging	Het
Slc33a1	A	G	3: 63,871,151 (GRCm39)	F154S	possibly damaging	Het
Wasf2	T	A	4: 132,921,732 (GRCm39)	S284T	unknown	Het
Wdtc1	T	C	4: 133,022,648 (GRCm39)	E566G	probably damaging	Het
Zcchc14	C	T	8: 122,335,877 (GRCm39)		probably benign	Het

Other mutations in Ncoa7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01406:Ncoa7	APN	10	30,566,836 (GRCm39)	missense	probably damaging	1.00
IGL01716:Ncoa7	APN	10	30,538,330 (GRCm39)	missense	probably damaging	0.96
IGL02114:Ncoa7	APN	10	30,538,360 (GRCm39)	missense	probably damaging	1.00
IGL02170:Ncoa7	APN	10	30,565,849 (GRCm39)	missense	possibly damaging	0.94
IGL02436:Ncoa7	APN	10	30,570,143 (GRCm39)	missense	probably damaging	1.00
IGL02499:Ncoa7	APN	10	30,566,885 (GRCm39)	missense	probably benign	0.04
IGL02533:Ncoa7	APN	10	30,598,781 (GRCm39)	missense	probably damaging	1.00
IGL02533:Ncoa7	APN	10	30,566,895 (GRCm39)	missense	possibly damaging	0.87
IGL02590:Ncoa7	APN	10	30,570,159 (GRCm39)	missense	probably damaging	1.00
IGL02657:Ncoa7	APN	10	30,528,972 (GRCm39)	missense	probably damaging	1.00
IGL03065:Ncoa7	APN	10	30,523,993 (GRCm39)	missense	probably damaging	1.00
IGL03088:Ncoa7	APN	10	30,574,121 (GRCm39)	splice site	probably null
IGL03090:Ncoa7	APN	10	30,538,396 (GRCm39)	missense	probably damaging	0.96
D6062:Ncoa7	UTSW	10	30,598,651 (GRCm39)	missense	probably damaging	1.00
R0058:Ncoa7	UTSW	10	30,523,537 (GRCm39)	missense	probably damaging	1.00
R0058:Ncoa7	UTSW	10	30,523,537 (GRCm39)	missense	probably damaging	1.00
R0578:Ncoa7	UTSW	10	30,577,913 (GRCm39)	critical splice donor site	probably null
R0729:Ncoa7	UTSW	10	30,567,575 (GRCm39)	missense	probably benign	0.00
R1538:Ncoa7	UTSW	10	30,570,207 (GRCm39)	missense	probably damaging	0.99
R1539:Ncoa7	UTSW	10	30,647,725 (GRCm39)	missense	probably damaging	1.00
R1574:Ncoa7	UTSW	10	30,570,097 (GRCm39)	missense	probably damaging	1.00
R1574:Ncoa7	UTSW	10	30,570,097 (GRCm39)	missense	probably damaging	1.00
R1624:Ncoa7	UTSW	10	30,580,655 (GRCm39)	missense	possibly damaging	0.87
R1639:Ncoa7	UTSW	10	30,577,988 (GRCm39)	missense	probably damaging	1.00
R1655:Ncoa7	UTSW	10	30,574,241 (GRCm39)	critical splice acceptor site	probably null
R1876:Ncoa7	UTSW	10	30,574,122 (GRCm39)	intron	probably benign
R1885:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1886:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1887:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1909:Ncoa7	UTSW	10	30,565,796 (GRCm39)	missense	probably damaging	1.00
R1938:Ncoa7	UTSW	10	30,574,166 (GRCm39)	missense	probably benign	0.02
R1965:Ncoa7	UTSW	10	30,530,426 (GRCm39)	nonsense	probably null
R1978:Ncoa7	UTSW	10	30,567,295 (GRCm39)	missense	probably benign
R2303:Ncoa7	UTSW	10	30,530,431 (GRCm39)	missense	probably damaging	1.00
R3777:Ncoa7	UTSW	10	30,565,752 (GRCm39)	missense	probably damaging	1.00
R3778:Ncoa7	UTSW	10	30,565,752 (GRCm39)	missense	probably damaging	1.00
R4026:Ncoa7	UTSW	10	30,598,720 (GRCm39)	missense	probably benign	0.02
R4230:Ncoa7	UTSW	10	30,574,253 (GRCm39)	splice site	probably null
R4667:Ncoa7	UTSW	10	30,566,786 (GRCm39)	missense	probably damaging	1.00
R4786:Ncoa7	UTSW	10	30,531,638 (GRCm39)	missense	probably benign	0.28
R4809:Ncoa7	UTSW	10	30,647,758 (GRCm39)	missense	possibly damaging	0.92
R4820:Ncoa7	UTSW	10	30,524,472 (GRCm39)	missense	probably damaging	1.00
R4839:Ncoa7	UTSW	10	30,598,655 (GRCm39)	missense	possibly damaging	0.93
R4861:Ncoa7	UTSW	10	30,580,608 (GRCm39)	missense	probably benign
R4861:Ncoa7	UTSW	10	30,580,608 (GRCm39)	missense	probably benign
R5271:Ncoa7	UTSW	10	30,598,725 (GRCm39)	missense	probably benign	0.02
R5384:Ncoa7	UTSW	10	30,598,813 (GRCm39)	missense	probably benign	0.00
R5418:Ncoa7	UTSW	10	30,524,035 (GRCm39)	missense	probably damaging	1.00
R5964:Ncoa7	UTSW	10	30,580,632 (GRCm39)	missense	probably damaging	1.00
R6257:Ncoa7	UTSW	10	30,570,173 (GRCm39)	missense	probably damaging	1.00
R6683:Ncoa7	UTSW	10	30,647,717 (GRCm39)	missense	probably damaging	0.99
R6813:Ncoa7	UTSW	10	30,572,188 (GRCm39)	missense	probably damaging	1.00
R6910:Ncoa7	UTSW	10	30,570,117 (GRCm39)	missense	possibly damaging	0.89
R7123:Ncoa7	UTSW	10	30,530,435 (GRCm39)	missense	probably benign	0.28
R7327:Ncoa7	UTSW	10	30,565,796 (GRCm39)	missense	probably damaging	1.00
R7412:Ncoa7	UTSW	10	30,598,847 (GRCm39)	missense	possibly damaging	0.94
R7638:Ncoa7	UTSW	10	30,598,794 (GRCm39)	missense	probably benign	0.35
R7653:Ncoa7	UTSW	10	30,570,239 (GRCm39)	missense	probably damaging	1.00
R7848:Ncoa7	UTSW	10	30,524,414 (GRCm39)	missense	possibly damaging	0.82
R7861:Ncoa7	UTSW	10	30,567,056 (GRCm39)	missense	probably benign	0.38
R8125:Ncoa7	UTSW	10	30,570,087 (GRCm39)	missense	possibly damaging	0.80
R8198:Ncoa7	UTSW	10	30,580,664 (GRCm39)	missense	probably benign	0.00
R8240:Ncoa7	UTSW	10	30,567,725 (GRCm39)	missense	probably benign	0.45
R8353:Ncoa7	UTSW	10	30,570,155 (GRCm39)	missense	probably damaging	1.00
R8509:Ncoa7	UTSW	10	30,572,048 (GRCm39)	missense	probably benign	0.00
R8861:Ncoa7	UTSW	10	30,567,364 (GRCm39)	missense	probably benign	0.02
R9040:Ncoa7	UTSW	10	30,530,389 (GRCm39)	missense	probably benign	0.00
R9136:Ncoa7	UTSW	10	30,567,628 (GRCm39)	missense	probably benign	0.00

Posted On

2016-08-02