Incidental Mutation 'IGL03224:Troap'
| ID |
413741 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Troap
|
| Ensembl Gene |
ENSMUSG00000032783 |
| Gene Name |
trophinin associated protein |
| Synonyms |
tastin, E130301L11Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.077)
|
| Stock # |
IGL03224
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
98972854-98981290 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 98979758 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 365
(T365A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000155404
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039665]
[ENSMUST00000064462]
[ENSMUST00000230054]
|
| AlphaFold |
B7ZNG4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000039665
AA Change: T365A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000035389
Gene: ENSMUSG00000032783
AA Change: T365A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
232 |
246 |
N/A |
INTRINSIC |
|
low complexity region
|
390 |
407 |
N/A |
INTRINSIC |
|
low complexity region
|
468 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
499 |
511 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064462
|
| SMART Domains |
Protein: ENSMUSP00000068402
Gene: ENSMUSG00000001076
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
13 |
N/A |
INTRINSIC |
|
C1Q
|
103 |
238 |
2.34e-34 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183449
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229224
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229740
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000230054
AA Change: T365A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230311
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ash1l |
T |
C |
3: 88,942,575 (GRCm39) |
|
probably benign |
Het |
| Capn10 |
T |
G |
1: 92,867,046 (GRCm39) |
V92G |
probably damaging |
Het |
| Cntn2 |
A |
G |
1: 132,450,780 (GRCm39) |
C532R |
probably damaging |
Het |
| Csf1r |
T |
C |
18: 61,245,134 (GRCm39) |
F233L |
probably damaging |
Het |
| Cts6 |
T |
C |
13: 61,349,547 (GRCm39) |
D82G |
probably damaging |
Het |
| Cym |
T |
C |
3: 107,126,048 (GRCm39) |
S72G |
possibly damaging |
Het |
| Cyp4a29 |
T |
A |
4: 115,104,247 (GRCm39) |
M105K |
probably damaging |
Het |
| Dhx35 |
T |
C |
2: 158,699,052 (GRCm39) |
|
probably benign |
Het |
| Dnah5 |
C |
A |
15: 28,459,300 (GRCm39) |
D4506E |
probably damaging |
Het |
| Dok5 |
T |
C |
2: 170,674,807 (GRCm39) |
F139L |
possibly damaging |
Het |
| Dync2h1 |
T |
C |
9: 7,076,235 (GRCm39) |
D2974G |
probably benign |
Het |
| Frem3 |
C |
T |
8: 81,340,092 (GRCm39) |
T795I |
probably damaging |
Het |
| Ints6l |
A |
G |
X: 55,543,287 (GRCm39) |
T525A |
probably damaging |
Het |
| Lrp1b |
T |
C |
2: 41,361,043 (GRCm39) |
T587A |
possibly damaging |
Het |
| Meikin |
A |
G |
11: 54,289,286 (GRCm39) |
M220V |
probably benign |
Het |
| Mmp12 |
T |
A |
9: 7,350,002 (GRCm39) |
|
probably benign |
Het |
| Mpp7 |
T |
C |
18: 7,403,269 (GRCm39) |
D347G |
probably benign |
Het |
| Myo3b |
A |
G |
2: 70,180,283 (GRCm39) |
Y1190C |
probably benign |
Het |
| Myo5c |
A |
G |
9: 75,185,525 (GRCm39) |
K963E |
probably benign |
Het |
| Nipbl |
T |
C |
15: 8,322,569 (GRCm39) |
D2614G |
probably damaging |
Het |
| Ppp1r3f |
A |
G |
X: 7,426,821 (GRCm39) |
V480A |
probably benign |
Het |
| Prkcb |
A |
T |
7: 122,116,147 (GRCm39) |
K209* |
probably null |
Het |
| Rasgef1a |
A |
G |
6: 118,066,767 (GRCm39) |
|
probably benign |
Het |
| Ryr3 |
A |
T |
2: 112,784,681 (GRCm39) |
C233* |
probably null |
Het |
| Scn8a |
A |
G |
15: 100,933,520 (GRCm39) |
R1534G |
probably damaging |
Het |
| Slitrk3 |
A |
T |
3: 72,957,263 (GRCm39) |
L503H |
possibly damaging |
Het |
| Spag17 |
A |
G |
3: 99,918,156 (GRCm39) |
K380E |
possibly damaging |
Het |
| Spata31d1a |
A |
G |
13: 59,848,840 (GRCm39) |
V1096A |
possibly damaging |
Het |
| Synrg |
C |
T |
11: 83,930,492 (GRCm39) |
T1278M |
possibly damaging |
Het |
| Teddm1a |
G |
T |
1: 153,767,763 (GRCm39) |
V76F |
possibly damaging |
Het |
| Vps35l |
A |
G |
7: 118,391,776 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Troap |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01140:Troap
|
APN |
15 |
98,980,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01949:Troap
|
APN |
15 |
98,979,102 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL02468:Troap
|
APN |
15 |
98,973,242 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02804:Troap
|
APN |
15 |
98,975,552 (GRCm39) |
splice site |
probably null |
|
|
R0617:Troap
|
UTSW |
15 |
98,980,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1085:Troap
|
UTSW |
15 |
98,980,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1872:Troap
|
UTSW |
15 |
98,973,233 (GRCm39) |
splice site |
probably benign |
|
|
R1884:Troap
|
UTSW |
15 |
98,975,779 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1937:Troap
|
UTSW |
15 |
98,975,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2063:Troap
|
UTSW |
15 |
98,980,344 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2065:Troap
|
UTSW |
15 |
98,980,344 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2066:Troap
|
UTSW |
15 |
98,980,344 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2068:Troap
|
UTSW |
15 |
98,980,344 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2087:Troap
|
UTSW |
15 |
98,976,698 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2159:Troap
|
UTSW |
15 |
98,975,467 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4282:Troap
|
UTSW |
15 |
98,976,713 (GRCm39) |
missense |
probably benign |
|
|
R5296:Troap
|
UTSW |
15 |
98,976,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5557:Troap
|
UTSW |
15 |
98,973,675 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5652:Troap
|
UTSW |
15 |
98,980,145 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5764:Troap
|
UTSW |
15 |
98,973,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Troap
|
UTSW |
15 |
98,980,569 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8008:Troap
|
UTSW |
15 |
98,973,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9319:Troap
|
UTSW |
15 |
98,975,444 (GRCm39) |
missense |
probably benign |
0.01 |
|
RF012:Troap
|
UTSW |
15 |
98,973,281 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Troap
|
UTSW |
15 |
98,975,458 (GRCm39) |
missense |
probably null |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation