Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01140:Troap'

52858

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Troap

Ensembl Gene

ENSMUSG00000032783

Gene Name

trophinin associated protein

Synonyms

tastin, E130301L11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL01140

Quality Score

Status

Chromosome

Chromosomal Location

98972854-98981290 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 98980027 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Histidine at position 402 (Q402H)

Ref Sequence

ENSEMBL: ENSMUSP00000155404 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039665] [ENSMUST00000064462] [ENSMUST00000230054]

AlphaFold

B7ZNG4

Predicted Effect

probably damaging
Transcript: ENSMUST00000039665
AA Change: Q402H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000035389
Gene: ENSMUSG00000032783
AA Change: Q402H

Domain	Start	End	E-Value	Type
low complexity region	232	246	N/A	INTRINSIC
low complexity region	390	407	N/A	INTRINSIC
low complexity region	468	479	N/A	INTRINSIC
low complexity region	499	511	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000064462

SMART Domains

Protein: ENSMUSP00000068402
Gene: ENSMUSG00000001076

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
C1Q	103	238	2.34e-34	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183449

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229224

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229740

Predicted Effect

probably damaging
Transcript: ENSMUST00000230054
AA Change: Q402H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230311

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afm	A	G	5: 90,672,726 (GRCm39)	E187G	probably damaging	Het
Asap2	T	C	12: 21,256,317 (GRCm39)	V205A	probably damaging	Het
Atg16l1	A	G	1: 87,702,575 (GRCm39)	I279V	probably benign	Het
Atp2b2	C	T	6: 113,766,932 (GRCm39)	V436I	possibly damaging	Het
Cald1	T	A	6: 34,739,196 (GRCm39)	S640T	possibly damaging	Het
Cdc23	A	G	18: 34,769,385 (GRCm39)	Y460H	probably benign	Het
Cenpk	T	A	13: 104,372,742 (GRCm39)		probably benign	Het
Ctss	A	G	3: 95,446,036 (GRCm39)	E52G	probably damaging	Het
Cuzd1	A	T	7: 130,913,523 (GRCm39)	C365S	probably damaging	Het
Cyp2c55	T	C	19: 39,007,093 (GRCm39)	L163P	probably benign	Het
Cyp4f37	T	C	17: 32,848,027 (GRCm39)	S182P	probably benign	Het
Flt4	G	T	11: 49,525,770 (GRCm39)	E740*	probably null	Het
Galntl6	T	A	8: 58,411,356 (GRCm39)	R291S	probably damaging	Het
Hydin	G	A	8: 111,124,694 (GRCm39)	V568I	probably benign	Het
Ift70a1	A	G	2: 75,810,259 (GRCm39)	V608A	probably benign	Het
Kcnab3	A	G	11: 69,220,705 (GRCm39)	K145R	probably benign	Het
Lama1	T	C	17: 68,109,928 (GRCm39)	V2183A	probably benign	Het
Lrmda	C	T	14: 22,646,585 (GRCm39)	A75V	possibly damaging	Het
Mbtd1	A	G	11: 93,815,258 (GRCm39)	E282G	probably damaging	Het
Muc19	A	T	15: 91,783,593 (GRCm39)		noncoding transcript	Het
Mug1	A	G	6: 121,859,693 (GRCm39)	T1231A	probably benign	Het
Nkpd1	A	G	7: 19,257,387 (GRCm39)	T389A	possibly damaging	Het
Nudt19	A	G	7: 35,247,336 (GRCm39)	*358Q	probably null	Het
Nup160	G	T	2: 90,530,909 (GRCm39)	M522I	possibly damaging	Het
Obsl1	T	A	1: 75,466,400 (GRCm39)		probably benign	Het
Or4m1	T	A	14: 50,557,732 (GRCm39)	I187F	probably damaging	Het
Or5ak24	T	C	2: 85,260,484 (GRCm39)	T230A	probably benign	Het
Or5b119	G	A	19: 13,457,151 (GRCm39)	T137I	possibly damaging	Het
Osbpl10	C	T	9: 115,005,070 (GRCm39)	P341S	probably benign	Het
Papola	C	A	12: 105,775,856 (GRCm39)	C7*	probably null	Het
Pld1	C	A	3: 28,132,386 (GRCm39)	L525I	probably benign	Het
Prom2	T	C	2: 127,373,125 (GRCm39)		probably benign	Het
Psmb5	G	A	14: 54,855,264 (GRCm39)	T62I	possibly damaging	Het
Sag	A	G	1: 87,751,086 (GRCm39)	E184G	probably benign	Het
Slc16a10	T	C	10: 39,952,921 (GRCm39)	Y191C	probably damaging	Het
Slc22a22	T	C	15: 57,126,734 (GRCm39)	T93A	probably damaging	Het
Ssx2ip	A	G	3: 146,133,598 (GRCm39)	Y231C	probably benign	Het
Trib1	A	G	15: 59,523,476 (GRCm39)	Y170C	probably damaging	Het
Trmt10a	G	A	3: 137,862,459 (GRCm39)		probably benign	Het
Vmn2r70	G	A	7: 85,214,379 (GRCm39)	Q258*	probably null	Het
Zfp128	A	G	7: 12,624,949 (GRCm39)	Y439C	probably benign	Het
Zmym1	A	G	4: 126,943,435 (GRCm39)	F318L	probably damaging	Het
Zswim2	A	G	2: 83,745,672 (GRCm39)	S589P	probably benign	Het

Other mutations in Troap

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01949:Troap	APN	15	98,979,102 (GRCm39)	missense	probably benign	0.08
IGL02468:Troap	APN	15	98,973,242 (GRCm39)	missense	possibly damaging	0.83
IGL02804:Troap	APN	15	98,975,552 (GRCm39)	splice site	probably null
IGL03224:Troap	APN	15	98,979,758 (GRCm39)	missense	probably benign
R0617:Troap	UTSW	15	98,980,541 (GRCm39)	missense	probably damaging	1.00
R1085:Troap	UTSW	15	98,980,044 (GRCm39)	missense	probably damaging	0.99
R1872:Troap	UTSW	15	98,973,233 (GRCm39)	splice site	probably benign
R1884:Troap	UTSW	15	98,975,779 (GRCm39)	missense	probably benign	0.00
R1937:Troap	UTSW	15	98,975,269 (GRCm39)	missense	probably damaging	1.00
R2063:Troap	UTSW	15	98,980,344 (GRCm39)	missense	probably benign	0.00
R2065:Troap	UTSW	15	98,980,344 (GRCm39)	missense	probably benign	0.00
R2066:Troap	UTSW	15	98,980,344 (GRCm39)	missense	probably benign	0.00
R2068:Troap	UTSW	15	98,980,344 (GRCm39)	missense	probably benign	0.00
R2087:Troap	UTSW	15	98,976,698 (GRCm39)	missense	possibly damaging	0.84
R2159:Troap	UTSW	15	98,975,467 (GRCm39)	missense	probably damaging	0.96
R4282:Troap	UTSW	15	98,976,713 (GRCm39)	missense	probably benign
R5296:Troap	UTSW	15	98,976,698 (GRCm39)	missense	probably damaging	0.99
R5557:Troap	UTSW	15	98,973,675 (GRCm39)	missense	possibly damaging	0.92
R5652:Troap	UTSW	15	98,980,145 (GRCm39)	missense	probably benign	0.00
R5764:Troap	UTSW	15	98,973,300 (GRCm39)	missense	probably damaging	1.00
R6891:Troap	UTSW	15	98,980,569 (GRCm39)	missense	possibly damaging	0.56
R8008:Troap	UTSW	15	98,973,511 (GRCm39)	missense	probably benign	0.00
R9319:Troap	UTSW	15	98,975,444 (GRCm39)	missense	probably benign	0.01
RF012:Troap	UTSW	15	98,973,281 (GRCm39)	missense	probably benign	0.10
Z1177:Troap	UTSW	15	98,975,458 (GRCm39)	missense	probably null

Posted On

2013-06-21