Mutagenetix > Incidental Mutation

Incidental Mutation 'R5740:Vmn2r118'

444764

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

Vmn2r119, EG668547, EG383258

MMRRC Submission

043196-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.128) question?

Stock #

R5740 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

55899341-55931672 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 55900103 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 600 (M600I)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably benign
Transcript: ENSMUST00000168440
AA Change: M600I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: M600I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921513I03Rik	G	A	10: 120,614,413 (GRCm39)		probably benign	Het
Arrdc5	T	A	17: 56,604,838 (GRCm39)	N150Y	probably benign	Het
Bag1	T	C	4: 40,941,526 (GRCm39)	Q269R	probably null	Het
C7	T	C	15: 5,086,522 (GRCm39)	N40D	probably benign	Het
Ccnt1	T	C	15: 98,442,381 (GRCm39)	I296V	probably benign	Het
Col19a1	C	T	1: 24,376,996 (GRCm39)	G450S	probably damaging	Het
F13a1	T	C	13: 37,082,178 (GRCm39)	T509A	probably benign	Het
Fgg	A	T	3: 82,918,832 (GRCm39)	T282S	probably benign	Het
Fzd7	A	G	1: 59,522,839 (GRCm39)	M241V	probably benign	Het
Gja1	G	A	10: 56,264,285 (GRCm39)	V215M	probably damaging	Het
Golgb1	T	C	16: 36,739,362 (GRCm39)	L2567P	probably damaging	Het
Grik2	T	C	10: 48,989,573 (GRCm39)	N819D	probably damaging	Het
Grik4	C	T	9: 42,719,863 (GRCm39)	R3H	possibly damaging	Het
Hecw2	T	C	1: 53,926,762 (GRCm39)	Y1079C	probably benign	Het
Hivep3	A	G	4: 119,953,220 (GRCm39)	E512G	possibly damaging	Het
Ino80	T	C	2: 119,261,510 (GRCm39)	D718G	probably damaging	Het
Ints10	G	A	8: 69,257,574 (GRCm39)	R258K	probably damaging	Het
Jak2	A	G	19: 29,239,824 (GRCm39)	K73E	possibly damaging	Het
Lrba	A	G	3: 86,235,649 (GRCm39)	I918V	probably damaging	Het
M1ap	T	C	6: 82,958,903 (GRCm39)	V178A	probably damaging	Het
Mcub	A	T	3: 129,712,374 (GRCm39)	M167K	probably benign	Het
Mgat4c	A	T	10: 102,225,182 (GRCm39)	K465N	possibly damaging	Het
Naip1	T	A	13: 100,569,009 (GRCm39)		probably null	Het
Ncbp3	T	A	11: 72,944,323 (GRCm39)	N108K	possibly damaging	Het
Npepps	A	T	11: 97,126,894 (GRCm39)	D455E	possibly damaging	Het
Or5b101	T	C	19: 13,004,926 (GRCm39)	M256V	probably benign	Het
Pan2	G	A	10: 128,144,033 (GRCm39)	G128S	probably damaging	Het
Ppp3cb	A	T	14: 20,551,664 (GRCm39)	I489N	possibly damaging	Het
Sdccag8	A	G	1: 176,658,716 (GRCm39)	T134A	probably benign	Het
Sh3tc1	T	C	5: 35,864,399 (GRCm39)	E596G	probably benign	Het
Shank1	T	C	7: 44,003,164 (GRCm39)	S1619P	possibly damaging	Het
Slc46a3	A	T	5: 147,816,643 (GRCm39)	C387*	probably null	Het
Slc5a5	G	T	8: 71,341,561 (GRCm39)		probably null	Het
Ttn	T	C	2: 76,721,718 (GRCm39)		probably benign	Het
Vangl1	T	C	3: 102,091,450 (GRCm39)	D212G	probably damaging	Het
Vmn1r52	T	A	6: 90,156,176 (GRCm39)	I160N	probably benign	Het
Vmn2r7	T	C	3: 64,614,654 (GRCm39)	I387V	probably benign	Het
Zfp369	A	G	13: 65,444,581 (GRCm39)	R575G	probably benign	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55,899,708 (GRCm39)	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55,900,204 (GRCm39)	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55,900,000 (GRCm39)	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55,915,585 (GRCm39)	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55,899,990 (GRCm39)	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55,899,619 (GRCm39)	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55,917,517 (GRCm39)	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55,931,598 (GRCm39)	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55,917,870 (GRCm39)	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55,899,655 (GRCm39)	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55,914,996 (GRCm39)	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55,915,616 (GRCm39)	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55,917,717 (GRCm39)	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55,917,717 (GRCm39)	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55,915,643 (GRCm39)	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55,918,021 (GRCm39)	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55,917,970 (GRCm39)	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55,917,772 (GRCm39)	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55,915,466 (GRCm39)	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55,915,620 (GRCm39)	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55,900,237 (GRCm39)	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55,917,935 (GRCm39)	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55,917,935 (GRCm39)	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55,915,496 (GRCm39)	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55,917,643 (GRCm39)	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55,915,083 (GRCm39)	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55,918,530 (GRCm39)	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55,899,456 (GRCm39)	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55,917,406 (GRCm39)	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55,918,556 (GRCm39)	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55,899,882 (GRCm39)	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55,899,925 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55,931,650 (GRCm39)	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55,915,421 (GRCm39)	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55,917,347 (GRCm39)	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55,917,665 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55,917,860 (GRCm39)	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55,899,581 (GRCm39)	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55,899,894 (GRCm39)	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55,918,565 (GRCm39)	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55,918,565 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55,899,765 (GRCm39)	missense	possibly damaging	0.46
R5927:Vmn2r118	UTSW	17	55,931,494 (GRCm39)	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55,899,871 (GRCm39)	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55,915,093 (GRCm39)	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55,899,996 (GRCm39)	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55,899,714 (GRCm39)	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55,899,348 (GRCm39)	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55,917,440 (GRCm39)	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55,915,496 (GRCm39)	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55,899,853 (GRCm39)	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55,900,242 (GRCm39)	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55,915,484 (GRCm39)	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55,917,936 (GRCm39)	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55,917,423 (GRCm39)	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55,915,057 (GRCm39)	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55,915,642 (GRCm39)	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55,917,216 (GRCm39)	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55,917,835 (GRCm39)	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55,918,649 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55,917,207 (GRCm39)	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55,899,837 (GRCm39)	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55,918,009 (GRCm39)	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55,915,415 (GRCm39)	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55,900,218 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55,917,655 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GATCTGCTGCAGGAGACATC -3'
(R):5'- CCATTGATTTGCTGTGCATCAG -3'

Sequencing Primer
(F):5'- CAGGAGACATCTGGCTGTGCTAG -3'
(R):5'- CCAGATGGTCAATATGCC -3'

Posted On

2016-11-21