Incidental Mutation 'R0530:Or10v5'
ID 49128
Institutional Source Beutler Lab
Gene Symbol Or10v5
Ensembl Gene ENSMUSG00000048292
Gene Name olfactory receptor family 10 subfamily V member 5
Synonyms MOR266-2, GA_x6K02T2RE5P-2172809-2171862, Olfr1417
MMRRC Submission 038722-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R0530 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 11805441-11806388 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11805556 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 278 (V278A)
Ref Sequence ENSEMBL: ENSMUSP00000149141 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061235] [ENSMUST00000214887]
AlphaFold Q8VGJ6
Predicted Effect probably benign
Transcript: ENSMUST00000061235
AA Change: V278A

PolyPhen 2 Score 0.258 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000062542
Gene: ENSMUSG00000048292
AA Change: V278A

DomainStartEndE-ValueType
Pfam:7tm_4 31 309 3.3e-53 PFAM
Pfam:7tm_1 41 291 3.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213141
Predicted Effect probably benign
Transcript: ENSMUST00000214887
AA Change: V278A

PolyPhen 2 Score 0.258 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.7%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 A G 5: 105,083,920 (GRCm39) W617R probably damaging Het
Adam34l A T 8: 44,079,568 (GRCm39) C219S probably benign Het
Cep83 A T 10: 94,555,450 (GRCm39) probably benign Het
Ces1e G A 8: 93,946,149 (GRCm39) probably benign Het
Ckap2 A G 8: 22,665,988 (GRCm39) probably benign Het
Clip1 C A 5: 123,778,594 (GRCm39) R443L probably damaging Het
Clmp A G 9: 40,672,302 (GRCm39) D44G probably benign Het
Cntnap2 G A 6: 46,506,839 (GRCm39) Q304* probably null Het
Cst7 A T 2: 150,412,435 (GRCm39) probably benign Het
Dclk3 A T 9: 111,311,789 (GRCm39) Y677F probably damaging Het
Dlat G T 9: 50,548,869 (GRCm39) N562K probably damaging Het
Elmod1 A T 9: 53,833,260 (GRCm39) Y182N probably damaging Het
Fzd10 T C 5: 128,679,077 (GRCm39) F266L probably damaging Het
Gm8258 A G 5: 104,923,952 (GRCm39) noncoding transcript Het
Gm9742 T A 13: 8,080,041 (GRCm39) noncoding transcript Het
Hdlbp T C 1: 93,358,039 (GRCm39) probably benign Het
Itga8 A G 2: 12,196,627 (GRCm39) S597P probably damaging Het
Kndc1 A T 7: 139,481,153 (GRCm39) I80F probably damaging Het
Ktn1 A G 14: 47,970,700 (GRCm39) N1192S probably benign Het
Ldha G A 7: 46,503,417 (GRCm39) V270M probably damaging Het
Lyst T C 13: 13,931,891 (GRCm39) probably benign Het
Map3k9 A T 12: 81,769,256 (GRCm39) F954I probably benign Het
Mroh2b A G 15: 4,963,877 (GRCm39) N823S probably damaging Het
Mycbp2 A T 14: 103,419,895 (GRCm39) N2480K probably damaging Het
Nat1 A G 8: 67,943,977 (GRCm39) K121E probably benign Het
Neurl1b T A 17: 26,660,519 (GRCm39) probably null Het
Nnt C A 13: 119,531,257 (GRCm39) L163F probably damaging Het
Otog A G 7: 45,947,668 (GRCm39) T2274A probably damaging Het
Pde4b G A 4: 102,459,848 (GRCm39) R561Q probably damaging Het
Pitpnm2 A G 5: 124,269,264 (GRCm39) F453L probably damaging Het
Pms1 T C 1: 53,235,972 (GRCm39) probably null Het
Pot1a A G 6: 25,771,540 (GRCm39) V227A possibly damaging Het
Prdx6b A G 2: 80,123,659 (GRCm39) N156S probably damaging Het
Ptpn9 A G 9: 56,968,417 (GRCm39) S586G probably benign Het
Serpina6 A T 12: 103,618,053 (GRCm39) N253K probably damaging Het
Slc12a2 T A 18: 58,052,608 (GRCm39) V809D possibly damaging Het
Slc2a8 C T 2: 32,863,696 (GRCm39) A449T probably benign Het
Slc6a6 A G 6: 91,701,939 (GRCm39) I116V probably null Het
Synj2 T A 17: 6,058,380 (GRCm39) S58R possibly damaging Het
Tafa3 T C 3: 104,679,487 (GRCm39) probably benign Het
Tktl2 T C 8: 66,965,831 (GRCm39) V463A probably damaging Het
Uchl5 T C 1: 143,670,082 (GRCm39) V105A possibly damaging Het
Usp9y T C Y: 1,333,600 (GRCm39) probably benign Het
Vmn1r200 T C 13: 22,579,667 (GRCm39) S148P probably damaging Het
Vmn2r50 A T 7: 9,781,644 (GRCm39) M367K possibly damaging Het
Vps13a T C 19: 16,632,570 (GRCm39) probably benign Het
Wdr26 A T 1: 181,013,635 (GRCm39) probably null Het
Wdr87-ps A G 7: 29,229,545 (GRCm39) noncoding transcript Het
Ythdc2 T A 18: 44,983,465 (GRCm39) M544K probably damaging Het
Zpld2 A G 4: 133,930,221 (GRCm39) I28T probably benign Het
Other mutations in Or10v5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1532:Or10v5 UTSW 19 11,805,983 (GRCm39) missense probably benign 0.00
R1730:Or10v5 UTSW 19 11,805,445 (GRCm39) missense probably benign 0.06
R2032:Or10v5 UTSW 19 11,805,664 (GRCm39) missense probably damaging 1.00
R2237:Or10v5 UTSW 19 11,805,814 (GRCm39) missense probably damaging 1.00
R2238:Or10v5 UTSW 19 11,805,814 (GRCm39) missense probably damaging 1.00
R2239:Or10v5 UTSW 19 11,805,814 (GRCm39) missense probably damaging 1.00
R4959:Or10v5 UTSW 19 11,806,300 (GRCm39) missense probably benign
R4973:Or10v5 UTSW 19 11,806,300 (GRCm39) missense probably benign
R5015:Or10v5 UTSW 19 11,805,482 (GRCm39) missense probably benign 0.00
R6799:Or10v5 UTSW 19 11,806,178 (GRCm39) missense possibly damaging 0.91
R6984:Or10v5 UTSW 19 11,805,668 (GRCm39) missense probably damaging 1.00
R7063:Or10v5 UTSW 19 11,805,548 (GRCm39) missense probably damaging 1.00
R7222:Or10v5 UTSW 19 11,806,021 (GRCm39) missense probably damaging 0.99
R8021:Or10v5 UTSW 19 11,806,256 (GRCm39) missense probably benign 0.39
R8748:Or10v5 UTSW 19 11,805,596 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGGGAGAGCAAAGCTATGTTCAC -3'
(R):5'- TGTGCAGACACCCATGTCCATGAG -3'

Sequencing Primer
(F):5'- TCCCCATGTTGAAGAATGAGTACC -3'
(R):5'- ATGTCCATGAGGCCACTCTG -3'
Posted On 2013-06-12