Incidental Mutation 'R6286:Slc22a13'
ID 508236
Institutional Source Beutler Lab
Gene Symbol Slc22a13
Ensembl Gene ENSMUSG00000074028
Gene Name solute carrier family 22 (organic cation transporter), member 13
Synonyms OCTL3, OCTL1, ORCTL3
MMRRC Submission 044456-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R6286 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 119022040-119038164 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 119037778 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 117 (E117*)
Ref Sequence ENSEMBL: ENSMUSP00000081855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084797] [ENSMUST00000170400]
AlphaFold Q6A4L0
Predicted Effect probably null
Transcript: ENSMUST00000084797
AA Change: E117*
SMART Domains Protein: ENSMUSP00000081855
Gene: ENSMUSG00000074028
AA Change: E117*

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:Sugar_tr 104 514 2.2e-41 PFAM
Pfam:MFS_1 133 468 2.6e-26 PFAM
Pfam:MFS_1 355 537 2.1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170400
SMART Domains Protein: ENSMUSP00000131982
Gene: ENSMUSG00000070280

DomainStartEndE-ValueType
transmembrane domain 68 90 N/A INTRINSIC
Pfam:Sugar_tr 150 555 1.2e-28 PFAM
Pfam:MFS_1 178 514 7.6e-28 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.7%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alk T A 17: 72,187,842 (GRCm39) M1300L probably damaging Het
C3 A T 17: 57,531,118 (GRCm39) I356N probably damaging Het
Cntnap5b T A 1: 100,182,798 (GRCm39) S276T possibly damaging Het
Cts7 C T 13: 61,500,584 (GRCm39) G321E probably damaging Het
Cyp11a1 G A 9: 57,924,701 (GRCm39) probably benign Het
Ddx4 T C 13: 112,750,269 (GRCm39) T421A probably damaging Het
Dnttip2 A G 3: 122,078,049 (GRCm39) T694A probably damaging Het
Eif3b G T 5: 140,405,566 (GRCm39) D151Y probably damaging Het
Fhad1 T A 4: 141,648,209 (GRCm39) E219V probably damaging Het
Gdf2 C T 14: 33,667,057 (GRCm39) R260C probably damaging Het
Gm14295 T C 2: 176,501,361 (GRCm39) Y284H possibly damaging Het
Gm45861 A G 8: 28,019,619 (GRCm39) T745A unknown Het
Grin2a G A 16: 9,579,639 (GRCm39) T208I possibly damaging Het
Ide T A 19: 37,255,409 (GRCm39) Y798F unknown Het
Llgl1 G A 11: 60,600,358 (GRCm39) G569D probably damaging Het
Mrpl9 G C 3: 94,351,097 (GRCm39) E92D probably benign Het
Muc16 T A 9: 18,555,685 (GRCm39) H3536L unknown Het
Nasp T C 4: 116,461,985 (GRCm39) Y526C probably damaging Het
Nfx1 A G 4: 40,986,728 (GRCm39) N404D probably damaging Het
Nsrp1 A G 11: 76,940,269 (GRCm39) I112T probably damaging Het
Or6c7 T C 10: 129,323,497 (GRCm39) L206P probably damaging Het
Or8b8 A T 9: 37,809,074 (GRCm39) I125F probably damaging Het
Oxsr1 A G 9: 119,093,948 (GRCm39) V235A probably damaging Het
Pamr1 C T 2: 102,471,293 (GRCm39) Q539* probably null Het
Pramel20 T A 4: 143,297,796 (GRCm39) V72D probably benign Het
Ptpn4 A G 1: 119,649,592 (GRCm39) probably null Het
Ranbp2 C T 10: 58,315,394 (GRCm39) A2038V probably benign Het
Rsf1 G GACGGCGGCA 7: 97,229,116 (GRCm39) probably benign Homo
Septin5 A G 16: 18,442,127 (GRCm39) V253A probably damaging Het
Skic3 T C 13: 76,291,359 (GRCm39) L993P probably damaging Het
Slc9c1 T C 16: 45,398,194 (GRCm39) I653T probably benign Het
Slco6c1 T A 1: 97,053,445 (GRCm39) H152L possibly damaging Het
Sp2 A C 11: 96,852,372 (GRCm39) V184G probably benign Het
Taok1 T A 11: 77,444,599 (GRCm39) H492L probably benign Het
Tas2r110 G A 6: 132,845,490 (GRCm39) D174N probably benign Het
Trim24 G A 6: 37,896,426 (GRCm39) probably null Het
Ttn G A 2: 76,581,321 (GRCm39) R21445* probably null Het
Ttn A G 2: 76,605,967 (GRCm39) Y16502H probably damaging Het
Vmn2r84 A C 10: 130,226,737 (GRCm39) M367R possibly damaging Het
Zfp46 T C 4: 136,018,320 (GRCm39) S385P probably damaging Het
Other mutations in Slc22a13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02828:Slc22a13 APN 9 119,024,773 (GRCm39) missense probably benign 0.25
IGL02871:Slc22a13 APN 9 119,025,077 (GRCm39) missense probably benign 0.01
R0764:Slc22a13 UTSW 9 119,037,746 (GRCm39) splice site probably null
R1469:Slc22a13 UTSW 9 119,022,361 (GRCm39) missense possibly damaging 0.67
R1469:Slc22a13 UTSW 9 119,022,361 (GRCm39) missense possibly damaging 0.67
R1545:Slc22a13 UTSW 9 119,038,113 (GRCm39) missense probably benign 0.00
R2154:Slc22a13 UTSW 9 119,037,753 (GRCm39) missense probably benign 0.00
R2321:Slc22a13 UTSW 9 119,024,694 (GRCm39) missense possibly damaging 0.61
R3808:Slc22a13 UTSW 9 119,025,143 (GRCm39) missense probably benign
R3840:Slc22a13 UTSW 9 119,037,855 (GRCm39) missense probably benign 0.18
R4736:Slc22a13 UTSW 9 119,022,698 (GRCm39) missense probably damaging 1.00
R6899:Slc22a13 UTSW 9 119,025,473 (GRCm39) missense probably damaging 1.00
R7579:Slc22a13 UTSW 9 119,024,226 (GRCm39) missense possibly damaging 0.62
R8755:Slc22a13 UTSW 9 119,038,126 (GRCm39) start codon destroyed probably damaging 0.98
Z1177:Slc22a13 UTSW 9 119,022,370 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGCTATGTACATGCATACAGGC -3'
(R):5'- TCTTCATGGTCCTTGATGAGGC -3'

Sequencing Primer
(F):5'- TACAGGCAACAGGTAGCTATATAC -3'
(R):5'- TGATGAGGCTCACCACTGTTCAG -3'
Posted On 2018-03-15