Incidental Mutation 'R6587:Lpar3'
ID 526379
Institutional Source Beutler Lab
Gene Symbol Lpar3
Ensembl Gene ENSMUSG00000036832
Gene Name lysophosphatidic acid receptor 3
Synonyms Edg7, LPA3
MMRRC Submission 044711-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6587 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 145926718-145991941 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145946918 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 199 (F199L)
Ref Sequence ENSEMBL: ENSMUSP00000037712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039164]
AlphaFold Q9EQ31
Predicted Effect probably damaging
Transcript: ENSMUST00000039164
AA Change: F199L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000037712
Gene: ENSMUSG00000036832
AA Change: F199L

DomainStartEndE-ValueType
Pfam:7tm_1 47 293 2.4e-37 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc2 TGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG TGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG 2: 25,162,550 (GRCm39) probably benign Het
Ank3 G T 10: 69,825,982 (GRCm39) probably benign Het
Ano3 C A 2: 110,628,249 (GRCm39) probably null Het
Arhgap39 A G 15: 76,621,699 (GRCm39) S301P probably damaging Het
Atad2 G T 15: 57,984,444 (GRCm39) Q295K probably benign Het
Camkmt T C 17: 85,421,243 (GRCm39) V115A possibly damaging Het
Cenpf T C 1: 189,390,571 (GRCm39) E1087G probably damaging Het
Cfhr2 T A 1: 139,738,596 (GRCm39) I322F probably benign Het
Chil6 T C 3: 106,312,197 (GRCm39) M35V probably benign Het
Cyp3a44 T C 5: 145,742,569 (GRCm39) T11A probably benign Het
Fiz1 C T 7: 5,011,400 (GRCm39) A373T possibly damaging Het
Ghitm A T 14: 36,847,146 (GRCm39) Y309* probably null Het
Klhl18 T C 9: 110,284,494 (GRCm39) H64R probably damaging Het
Krt78 T C 15: 101,860,704 (GRCm39) K201R probably benign Het
Mindy3 G A 2: 12,352,927 (GRCm39) Q425* probably null Het
Or5b114-ps1 A T 19: 13,352,977 (GRCm39) Y217F unknown Het
P2rx7 A C 5: 122,802,613 (GRCm39) N207T probably damaging Het
Pcdhb7 T G 18: 37,477,156 (GRCm39) L764R probably benign Het
Pgap6 G A 17: 26,340,538 (GRCm39) V641I probably benign Het
Sbf2 T C 7: 110,040,182 (GRCm39) Y378C probably damaging Het
Slc23a2 C T 2: 131,920,401 (GRCm39) S168N possibly damaging Het
Tmem260 A G 14: 48,733,913 (GRCm39) probably null Het
Tmprss15 T G 16: 78,868,317 (GRCm39) L198F probably benign Het
Tulp4 C T 17: 6,282,146 (GRCm39) T725I possibly damaging Het
Tut4 C A 4: 108,336,646 (GRCm39) N123K probably benign Het
Urb2 G T 8: 124,757,864 (GRCm39) E1190D probably damaging Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zp3 A G 5: 136,016,352 (GRCm39) D318G possibly damaging Het
Other mutations in Lpar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02444:Lpar3 APN 3 145,946,949 (GRCm39) missense probably damaging 1.00
R0656:Lpar3 UTSW 3 145,946,426 (GRCm39) missense possibly damaging 0.54
R0893:Lpar3 UTSW 3 145,946,348 (GRCm39) missense possibly damaging 0.82
R1809:Lpar3 UTSW 3 145,946,303 (GRCm39) splice site probably benign
R4937:Lpar3 UTSW 3 145,990,506 (GRCm39) missense probably damaging 0.98
R6116:Lpar3 UTSW 3 145,946,352 (GRCm39) missense possibly damaging 0.70
R7232:Lpar3 UTSW 3 145,947,061 (GRCm39) critical splice donor site probably null
R8029:Lpar3 UTSW 3 145,946,718 (GRCm39) missense probably benign 0.01
R8266:Lpar3 UTSW 3 145,946,385 (GRCm39) missense probably benign 0.02
R9676:Lpar3 UTSW 3 145,990,434 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTGGAAAGACACATGTCCATC -3'
(R):5'- TGGCTGCATACATGGGAAC -3'

Sequencing Primer
(F):5'- TGAGAGTCCACAGCAACTTG -3'
(R):5'- AACCATGGCTCACTTGGC -3'
Posted On 2018-06-25