Incidental Mutation 'R7290:Kif21a'
| ID |
566363 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
045362-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7290 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 90851432 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 995
(C995*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
[ENSMUST00000229801]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000067205
AA Change: C995*
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: C995*
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000088614
AA Change: C1008*
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: C1008*
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100304
AA Change: C1008*
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: C1008*
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109287
AA Change: C995*
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: C995*
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109288
AA Change: C995*
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: C995*
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229801
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
T |
A |
11: 109,921,714 (GRCm39) |
M1447L |
probably benign |
Het |
| Adam30 |
G |
A |
3: 98,070,257 (GRCm39) |
V697I |
probably benign |
Het |
| Adamts12 |
A |
G |
15: 11,277,452 (GRCm39) |
N689D |
probably benign |
Het |
| Adamts15 |
T |
C |
9: 30,813,906 (GRCm39) |
K753R |
probably benign |
Het |
| Adra2a |
T |
C |
19: 54,034,835 (GRCm39) |
F64L |
probably damaging |
Het |
| Ankub1 |
A |
G |
3: 57,580,345 (GRCm39) |
L104P |
probably damaging |
Het |
| Arel1 |
A |
G |
12: 84,988,719 (GRCm39) |
V10A |
probably benign |
Het |
| Atad2 |
A |
T |
15: 57,962,047 (GRCm39) |
N1165K |
probably benign |
Het |
| Atp6v0d2 |
T |
A |
4: 19,880,060 (GRCm39) |
D279V |
probably benign |
Het |
| Cadps |
A |
T |
14: 12,616,099 (GRCm38) |
D310E |
probably damaging |
Het |
| Caskin2 |
T |
C |
11: 115,695,615 (GRCm39) |
I249V |
possibly damaging |
Het |
| Cdh23 |
T |
C |
10: 60,212,620 (GRCm39) |
N1598S |
probably benign |
Het |
| Cep250 |
A |
T |
2: 155,834,682 (GRCm39) |
Q2202H |
probably benign |
Het |
| Ces5a |
T |
A |
8: 94,261,311 (GRCm39) |
T35S |
probably damaging |
Het |
| Cnot11 |
G |
A |
1: 39,579,020 (GRCm39) |
W295* |
probably null |
Het |
| Cntnap5a |
G |
T |
1: 116,149,619 (GRCm39) |
W565L |
probably damaging |
Het |
| Dgka |
T |
C |
10: 128,569,468 (GRCm39) |
E148G |
probably damaging |
Het |
| Dnah14 |
G |
A |
1: 181,455,739 (GRCm39) |
D955N |
probably benign |
Het |
| Erbin |
G |
A |
13: 103,998,834 (GRCm39) |
T184I |
probably damaging |
Het |
| Fam20c |
G |
T |
5: 138,793,309 (GRCm39) |
G477W |
probably damaging |
Het |
| Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
| Fgfr4 |
T |
C |
13: 55,309,262 (GRCm39) |
V433A |
probably benign |
Het |
| Gal3st1 |
A |
T |
11: 3,948,093 (GRCm39) |
Q100L |
possibly damaging |
Het |
| Gfra2 |
T |
C |
14: 71,163,380 (GRCm39) |
F221S |
probably damaging |
Het |
| Gm19965 |
G |
A |
1: 116,748,921 (GRCm39) |
V201M |
|
Het |
| Gnb1l |
A |
T |
16: 18,382,806 (GRCm39) |
T282S |
probably benign |
Het |
| Gpr171 |
A |
T |
3: 59,005,147 (GRCm39) |
N209K |
probably benign |
Het |
| Greb1 |
G |
A |
12: 16,761,739 (GRCm39) |
T547I |
probably damaging |
Het |
| Ifi214 |
A |
T |
1: 173,357,097 (GRCm39) |
V2E |
probably benign |
Het |
| Ighv1-71 |
T |
C |
12: 115,706,267 (GRCm39) |
M1V |
probably null |
Het |
| Itm2b |
C |
T |
14: 73,605,785 (GRCm39) |
G67D |
probably damaging |
Het |
| Kifc2 |
A |
T |
15: 76,544,904 (GRCm39) |
Y13F |
probably damaging |
Het |
| Lamb1 |
T |
A |
12: 31,315,595 (GRCm39) |
V59D |
probably benign |
Het |
| Lhx1 |
A |
T |
11: 84,412,703 (GRCm39) |
D163E |
probably damaging |
Het |
| Lrrc1 |
A |
T |
9: 77,365,121 (GRCm39) |
Y187N |
probably benign |
Het |
| Map3k1 |
C |
A |
13: 111,904,645 (GRCm39) |
V380F |
probably damaging |
Het |
| Mapk11 |
T |
C |
15: 89,028,511 (GRCm39) |
D283G |
probably damaging |
Het |
| Mccc2 |
G |
T |
13: 100,091,207 (GRCm39) |
A430D |
probably damaging |
Het |
| Mest |
A |
G |
6: 30,747,158 (GRCm39) |
N340S |
unknown |
Het |
| Mms22l |
T |
C |
4: 24,517,139 (GRCm39) |
L340P |
probably benign |
Het |
| Mrnip |
A |
G |
11: 50,087,808 (GRCm39) |
Y110C |
possibly damaging |
Het |
| Mtmr4 |
A |
G |
11: 87,502,063 (GRCm39) |
T706A |
probably benign |
Het |
| Muc21 |
G |
A |
17: 35,929,761 (GRCm39) |
A1475V |
unknown |
Het |
| Ncstn |
A |
G |
1: 171,900,373 (GRCm39) |
F234S |
probably benign |
Het |
| Nrp1 |
T |
C |
8: 129,202,777 (GRCm39) |
|
probably null |
Het |
| Nup37 |
T |
G |
10: 88,010,356 (GRCm39) |
C217G |
probably damaging |
Het |
| Or8g22 |
A |
G |
9: 38,958,694 (GRCm39) |
L7P |
unknown |
Het |
| Pdzrn3 |
T |
C |
6: 101,128,206 (GRCm39) |
N820S |
probably benign |
Het |
| Pgap1 |
A |
T |
1: 54,587,225 (GRCm39) |
F117Y |
possibly damaging |
Het |
| Phip |
A |
T |
9: 82,753,346 (GRCm39) |
F1799L |
possibly damaging |
Het |
| Ppm1f |
T |
A |
16: 16,728,819 (GRCm39) |
F74I |
probably benign |
Het |
| Prpf8 |
C |
A |
11: 75,384,783 (GRCm39) |
N775K |
possibly damaging |
Het |
| Ptdss2 |
T |
C |
7: 140,731,693 (GRCm39) |
I167T |
possibly damaging |
Het |
| Ptpn18 |
G |
A |
1: 34,501,892 (GRCm39) |
|
probably null |
Het |
| Rbl2 |
C |
A |
8: 91,841,669 (GRCm39) |
A955D |
probably benign |
Het |
| Rgl1 |
A |
G |
1: 152,420,146 (GRCm39) |
S366P |
possibly damaging |
Het |
| Rit2 |
A |
T |
18: 31,376,221 (GRCm39) |
M38K |
possibly damaging |
Het |
| Robo1 |
A |
G |
16: 72,801,408 (GRCm39) |
M1011V |
probably benign |
Het |
| Senp6 |
A |
T |
9: 80,043,797 (GRCm39) |
E809D |
probably benign |
Het |
| Stard3 |
G |
A |
11: 98,269,045 (GRCm39) |
|
probably null |
Het |
| Taar3 |
T |
G |
10: 23,826,298 (GRCm39) |
Y281* |
probably null |
Het |
| Tacc2 |
G |
T |
7: 130,331,103 (GRCm39) |
K352N |
probably benign |
Het |
| Tamalin |
G |
A |
15: 101,129,419 (GRCm39) |
S234N |
probably damaging |
Het |
| Tasor |
T |
A |
14: 27,160,610 (GRCm39) |
I124N |
probably damaging |
Het |
| Tdpoz4 |
G |
A |
3: 93,704,155 (GRCm39) |
V151I |
not run |
Het |
| Tenm2 |
A |
G |
11: 35,914,298 (GRCm39) |
L2413P |
probably damaging |
Het |
| Tgm6 |
T |
C |
2: 129,983,110 (GRCm39) |
V233A |
probably damaging |
Het |
| Tlx3 |
G |
A |
11: 33,153,514 (GRCm39) |
|
probably benign |
Het |
| Tmem94 |
G |
T |
11: 115,677,082 (GRCm39) |
R118L |
possibly damaging |
Het |
| Trim23 |
C |
A |
13: 104,323,941 (GRCm39) |
H133Q |
probably damaging |
Het |
| Unc80 |
A |
T |
1: 66,640,356 (GRCm39) |
D1421V |
probably damaging |
Het |
| Vmn1r172 |
A |
G |
7: 23,360,048 (GRCm39) |
N311S |
unknown |
Het |
| Vps25 |
T |
A |
11: 101,149,775 (GRCm39) |
L153Q |
probably damaging |
Het |
| Wbp1l |
G |
T |
19: 46,611,876 (GRCm39) |
|
probably benign |
Het |
| Ythdc2 |
A |
G |
18: 44,970,558 (GRCm39) |
I291V |
possibly damaging |
Het |
| Zfp2 |
A |
G |
11: 50,791,570 (GRCm39) |
C158R |
probably damaging |
Het |
| Zfp786 |
G |
A |
6: 47,796,929 (GRCm39) |
P670S |
probably damaging |
Het |
| Zfp827 |
G |
A |
8: 79,916,442 (GRCm39) |
R339H |
possibly damaging |
Het |
| Zmym6 |
C |
T |
4: 127,017,294 (GRCm39) |
A1025V |
possibly damaging |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TATCTTTAAGACCCTGAGCATCC -3'
(R):5'- CCATCATTCTGTCTCGAATGTACTG -3'
Sequencing Primer
(F):5'- ACCATACTTCTAGCATCTGGGAG -3'
(R):5'- TTTGTTTGTTTGTTTTATAGCAACGG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation