Incidental Mutation 'R4974:Kif21a'
| ID |
382530 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
042569-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4974 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 90833213 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Asparagine
at position 1317
(H1317N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097877
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
[ENSMUST00000229801]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067205
AA Change: H1268N
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: H1268N
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088614
AA Change: H1317N
PolyPhen 2
Score 0.108 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: H1317N
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100304
AA Change: H1317N
PolyPhen 2
Score 0.159 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: H1317N
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109287
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109288
AA Change: H1218N
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: H1218N
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229801
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000230487
|
| Meta Mutation Damage Score |
0.0849 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
97% (94/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A730061H03Rik |
C |
T |
14: 55,797,574 (GRCm39) |
|
probably benign |
Het |
| Acsf2 |
A |
C |
11: 94,460,155 (GRCm39) |
M399R |
possibly damaging |
Het |
| Adra2c |
C |
A |
5: 35,438,268 (GRCm39) |
R347S |
probably benign |
Het |
| Akap9 |
A |
G |
5: 4,011,466 (GRCm39) |
K723R |
possibly damaging |
Het |
| Anxa9 |
A |
C |
3: 95,215,324 (GRCm39) |
|
probably benign |
Het |
| Aqr |
T |
C |
2: 113,943,832 (GRCm39) |
H1102R |
probably damaging |
Het |
| Armh3 |
A |
T |
19: 45,808,726 (GRCm39) |
F655Y |
probably damaging |
Het |
| Arrdc2 |
A |
G |
8: 71,290,162 (GRCm39) |
V173A |
probably benign |
Het |
| Aspm |
T |
C |
1: 139,405,748 (GRCm39) |
V1545A |
probably benign |
Het |
| Bbs5 |
C |
T |
2: 69,477,578 (GRCm39) |
|
probably benign |
Het |
| Bnip2 |
A |
G |
9: 69,910,716 (GRCm39) |
T255A |
possibly damaging |
Het |
| Cacna1b |
T |
C |
2: 24,538,535 (GRCm39) |
T1531A |
probably damaging |
Het |
| Cast |
T |
C |
13: 74,955,942 (GRCm39) |
K9R |
probably benign |
Het |
| Cfap46 |
A |
T |
7: 139,187,104 (GRCm39) |
|
probably null |
Het |
| Cfap57 |
G |
T |
4: 118,450,251 (GRCm39) |
L624M |
probably damaging |
Het |
| Cyp2c39 |
A |
T |
19: 39,552,323 (GRCm39) |
M339L |
probably benign |
Het |
| Dcst1 |
T |
A |
3: 89,265,110 (GRCm39) |
T247S |
probably benign |
Het |
| Dnajc18 |
T |
A |
18: 35,816,372 (GRCm39) |
I189F |
possibly damaging |
Het |
| Eef2kmt |
T |
C |
16: 5,066,876 (GRCm39) |
T126A |
probably benign |
Het |
| Epha2 |
A |
G |
4: 141,049,016 (GRCm39) |
E624G |
probably damaging |
Het |
| Erbb3 |
G |
A |
10: 128,408,317 (GRCm39) |
H866Y |
probably benign |
Het |
| F13a1 |
C |
T |
13: 37,100,837 (GRCm39) |
|
probably null |
Het |
| Fgd3 |
T |
A |
13: 49,432,078 (GRCm39) |
N392I |
probably damaging |
Het |
| Fgf7 |
A |
T |
2: 125,930,160 (GRCm39) |
M98L |
probably benign |
Het |
| G2e3 |
T |
A |
12: 51,415,922 (GRCm39) |
S553T |
probably benign |
Het |
| Glipr1 |
C |
A |
10: 111,829,411 (GRCm39) |
E117* |
probably null |
Het |
| Gm11060 |
A |
T |
2: 104,924,128 (GRCm39) |
|
probably benign |
Het |
| Gm4787 |
A |
G |
12: 81,424,403 (GRCm39) |
I585T |
probably damaging |
Het |
| Gm6055 |
A |
T |
14: 48,316,915 (GRCm39) |
|
noncoding transcript |
Het |
| Gpbar1 |
TACCAC |
TAC |
1: 74,318,704 (GRCm39) |
|
probably benign |
Het |
| Gpt2 |
T |
A |
8: 86,246,068 (GRCm39) |
|
probably benign |
Het |
| Gtf2ird1 |
A |
T |
5: 134,386,685 (GRCm39) |
Y345* |
probably null |
Het |
| Hmcn1 |
T |
A |
1: 150,695,200 (GRCm39) |
T235S |
probably benign |
Het |
| Igkv5-48 |
A |
G |
6: 69,703,738 (GRCm39) |
Y56H |
possibly damaging |
Het |
| Il17re |
C |
T |
6: 113,446,530 (GRCm39) |
T427I |
probably benign |
Het |
| Itpr3 |
A |
T |
17: 27,302,582 (GRCm39) |
D80V |
probably damaging |
Het |
| Kif28 |
T |
C |
1: 179,526,209 (GRCm39) |
K144E |
probably damaging |
Het |
| Kif4-ps |
A |
C |
12: 101,113,330 (GRCm39) |
|
noncoding transcript |
Het |
| Klk1b11 |
C |
T |
7: 43,427,160 (GRCm39) |
T148I |
probably damaging |
Het |
| Klkb1 |
T |
A |
8: 45,739,995 (GRCm39) |
H99L |
probably damaging |
Het |
| Kpna6 |
A |
C |
4: 129,550,198 (GRCm39) |
|
probably null |
Het |
| Lama3 |
G |
T |
18: 12,685,883 (GRCm39) |
K1132N |
probably damaging |
Het |
| Lcp1 |
T |
A |
14: 75,445,911 (GRCm39) |
L264* |
probably null |
Het |
| Map2 |
T |
C |
1: 66,452,664 (GRCm39) |
V360A |
probably benign |
Het |
| Med13 |
A |
T |
11: 86,189,673 (GRCm39) |
S1079T |
probably damaging |
Het |
| Mettl13 |
A |
G |
1: 162,364,789 (GRCm39) |
M162T |
probably damaging |
Het |
| Mppe1 |
T |
G |
18: 67,361,133 (GRCm39) |
E208A |
probably benign |
Het |
| Msantd2 |
A |
C |
9: 37,400,675 (GRCm39) |
K19T |
possibly damaging |
Het |
| Mylk3 |
A |
G |
8: 86,091,412 (GRCm39) |
V131A |
probably damaging |
Het |
| Myocd |
A |
T |
11: 65,074,299 (GRCm39) |
S609T |
possibly damaging |
Het |
| Ncbp3 |
G |
A |
11: 72,944,355 (GRCm39) |
|
probably null |
Het |
| Neb |
T |
A |
2: 52,136,871 (GRCm39) |
L3203F |
probably damaging |
Het |
| Notch2 |
C |
A |
3: 98,046,949 (GRCm39) |
T1756K |
probably benign |
Het |
| Nphp4 |
A |
T |
4: 152,622,250 (GRCm39) |
R544W |
probably damaging |
Het |
| Or3a1c |
A |
T |
11: 74,046,745 (GRCm39) |
Y255F |
probably benign |
Het |
| Or4p18 |
T |
G |
2: 88,232,756 (GRCm39) |
H174P |
probably damaging |
Het |
| Or5c1 |
A |
T |
2: 37,222,578 (GRCm39) |
D273V |
probably damaging |
Het |
| Parp4 |
T |
A |
14: 56,827,355 (GRCm39) |
V163E |
possibly damaging |
Het |
| Pcdhgb1 |
C |
A |
18: 37,815,425 (GRCm39) |
Q639K |
probably benign |
Het |
| Pcnx2 |
A |
G |
8: 126,577,869 (GRCm39) |
V936A |
probably benign |
Het |
| Pcsk7 |
T |
A |
9: 45,830,160 (GRCm39) |
M418K |
probably damaging |
Het |
| Pglyrp4 |
T |
C |
3: 90,640,314 (GRCm39) |
I188T |
probably benign |
Het |
| Pgs1 |
A |
G |
11: 117,896,345 (GRCm39) |
R339G |
probably benign |
Het |
| Pik3r3 |
A |
G |
4: 116,143,388 (GRCm39) |
I294V |
probably benign |
Het |
| Pik3r6 |
A |
G |
11: 68,430,771 (GRCm39) |
D520G |
probably damaging |
Het |
| Pkdrej |
A |
G |
15: 85,704,610 (GRCm39) |
V442A |
probably benign |
Het |
| Ppfibp1 |
T |
A |
6: 146,931,917 (GRCm39) |
|
probably benign |
Het |
| Ppp3ca |
C |
A |
3: 136,640,810 (GRCm39) |
Q454K |
possibly damaging |
Het |
| Ppp5c |
A |
T |
7: 16,743,861 (GRCm39) |
M191K |
probably damaging |
Het |
| Prl4a1 |
A |
T |
13: 28,207,308 (GRCm39) |
Y194F |
possibly damaging |
Het |
| Ptpn21 |
G |
T |
12: 98,646,362 (GRCm39) |
T1032K |
probably damaging |
Het |
| Ptprh |
A |
T |
7: 4,554,006 (GRCm39) |
|
probably null |
Het |
| Ptprm |
T |
A |
17: 66,985,062 (GRCm39) |
R1447S |
probably benign |
Het |
| Pxk |
T |
A |
14: 8,140,734 (GRCm38) |
D236E |
probably damaging |
Het |
| Qars1 |
T |
C |
9: 108,386,130 (GRCm39) |
F107S |
probably damaging |
Het |
| Rbbp6 |
A |
G |
7: 122,599,031 (GRCm39) |
|
probably benign |
Het |
| Rptor |
A |
T |
11: 119,712,466 (GRCm39) |
|
probably benign |
Het |
| Rtn4 |
T |
A |
11: 29,690,994 (GRCm39) |
M1095K |
probably damaging |
Het |
| Serpinb3b |
T |
A |
1: 107,082,445 (GRCm39) |
H273L |
probably benign |
Het |
| Sgce |
G |
A |
6: 4,689,630 (GRCm39) |
T401M |
probably benign |
Het |
| Slc12a6 |
C |
T |
2: 112,188,870 (GRCm39) |
R1083W |
probably damaging |
Het |
| Slc45a4 |
A |
T |
15: 73,456,299 (GRCm39) |
M635K |
probably damaging |
Het |
| Slc6a1 |
T |
A |
6: 114,284,662 (GRCm39) |
V240D |
probably damaging |
Het |
| Snx9 |
G |
A |
17: 5,952,794 (GRCm39) |
|
probably null |
Het |
| Spred3 |
A |
G |
7: 28,867,249 (GRCm39) |
V49A |
probably damaging |
Het |
| Tars1 |
A |
G |
15: 11,390,477 (GRCm39) |
F334S |
probably damaging |
Het |
| Tdpoz1 |
A |
G |
3: 93,578,454 (GRCm39) |
V110A |
probably benign |
Het |
| Tfrc |
T |
G |
16: 32,437,097 (GRCm39) |
V252G |
probably damaging |
Het |
| Tm6sf2 |
T |
C |
8: 70,528,128 (GRCm39) |
|
probably benign |
Het |
| Txlnb |
T |
C |
10: 17,714,717 (GRCm39) |
V383A |
probably damaging |
Het |
| Utp20 |
C |
A |
10: 88,652,811 (GRCm39) |
V368L |
probably benign |
Het |
| Vmn2r12 |
A |
T |
5: 109,239,372 (GRCm39) |
V397E |
probably damaging |
Het |
| Zdhhc12 |
G |
A |
2: 29,981,538 (GRCm39) |
R175W |
probably damaging |
Het |
| Zfyve9 |
A |
G |
4: 108,538,097 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTTGCCGCTACTTTACAAG -3'
(R):5'- CTGATTTCGGGTGCAAACAG -3'
Sequencing Primer
(F):5'- TGCCGCTACTTTACAAGATAAACTC -3'
(R):5'- TTTCGGGTGCAAACAGGAAAAC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation