Incidental Mutation 'R0698:Taar2'
ID |
62917 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Taar2
|
Ensembl Gene |
ENSMUSG00000059763 |
Gene Name |
trace amine-associated receptor 2 |
Synonyms |
Gpr58 |
MMRRC Submission |
038882-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0698 (G1)
|
Quality Score |
154 |
Status
|
Not validated
|
Chromosome |
10 |
Chromosomal Location |
23814470-23817481 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 23817393 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Histidine
at position 311
(R311H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000078137
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079134]
|
AlphaFold |
Q5QD17 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000079134
AA Change: R311H
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000078137 Gene: ENSMUSG00000059763 AA Change: R311H
Domain | Start | End | E-Value | Type |
Pfam:7TM_GPCR_Srsx
|
42 |
318 |
2.4e-10 |
PFAM |
Pfam:7tm_1
|
48 |
303 |
2.9e-54 |
PFAM |
|
Meta Mutation Damage Score |
0.4819 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 95.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adcy5 |
C |
T |
16: 35,110,452 (GRCm39) |
T873M |
possibly damaging |
Het |
Ap4e1 |
G |
A |
2: 126,905,283 (GRCm39) |
E985K |
probably benign |
Het |
Arhgap18 |
T |
C |
10: 26,788,625 (GRCm39) |
I579T |
probably damaging |
Het |
Arhgef11 |
G |
T |
3: 87,640,766 (GRCm39) |
A1308S |
probably benign |
Het |
Arhgef5 |
A |
G |
6: 43,250,275 (GRCm39) |
E342G |
probably damaging |
Het |
Atm |
T |
C |
9: 53,426,539 (GRCm39) |
E573G |
probably damaging |
Het |
Baz1b |
T |
C |
5: 135,227,075 (GRCm39) |
V92A |
probably damaging |
Het |
Cmya5 |
A |
G |
13: 93,232,065 (GRCm39) |
S1008P |
probably damaging |
Het |
Col6a1 |
A |
G |
10: 76,552,114 (GRCm39) |
V459A |
unknown |
Het |
Cpne4 |
T |
C |
9: 104,802,994 (GRCm39) |
S213P |
probably damaging |
Het |
Dock10 |
T |
A |
1: 80,507,895 (GRCm39) |
Q1672L |
probably damaging |
Het |
Grm8 |
C |
T |
6: 27,363,913 (GRCm39) |
C534Y |
probably damaging |
Het |
Ints7 |
A |
G |
1: 191,326,576 (GRCm39) |
M183V |
probably damaging |
Het |
Invs |
T |
G |
4: 48,396,364 (GRCm39) |
S346A |
probably benign |
Het |
Krtap9-3 |
C |
A |
11: 99,488,663 (GRCm39) |
C73F |
probably damaging |
Het |
Lrrtm4 |
T |
C |
6: 79,999,911 (GRCm39) |
L441P |
probably damaging |
Het |
Map4 |
C |
T |
9: 109,897,856 (GRCm39) |
R81* |
probably null |
Het |
Med1 |
A |
G |
11: 98,046,515 (GRCm39) |
|
probably benign |
Het |
Necab1 |
T |
C |
4: 15,005,041 (GRCm39) |
N141S |
probably benign |
Het |
Or1d2 |
A |
T |
11: 74,255,968 (GRCm39) |
I158F |
probably benign |
Het |
Pcdhb2 |
A |
T |
18: 37,430,419 (GRCm39) |
E797D |
probably benign |
Het |
Pclo |
T |
C |
5: 14,762,530 (GRCm39) |
Y3668H |
unknown |
Het |
Peg10 |
T |
A |
6: 4,756,835 (GRCm39) |
|
probably benign |
Het |
Psd2 |
A |
G |
18: 36,145,764 (GRCm39) |
I723V |
probably benign |
Het |
Ptprn2 |
C |
T |
12: 116,685,750 (GRCm39) |
R70* |
probably null |
Het |
R3hdm1 |
A |
G |
1: 128,109,476 (GRCm39) |
Y309C |
probably damaging |
Het |
Rab13 |
C |
T |
3: 90,132,043 (GRCm39) |
T69M |
probably damaging |
Het |
Rpl32 |
T |
C |
6: 115,782,551 (GRCm39) |
N126S |
probably benign |
Het |
Sis |
C |
A |
3: 72,817,831 (GRCm39) |
A1461S |
probably damaging |
Het |
Slc2a13 |
T |
C |
15: 91,205,870 (GRCm39) |
D439G |
probably benign |
Het |
Spta1 |
T |
C |
1: 174,008,670 (GRCm39) |
L258P |
probably damaging |
Het |
Synj1 |
T |
C |
16: 90,757,503 (GRCm39) |
T882A |
probably benign |
Het |
Tada3 |
A |
T |
6: 113,343,968 (GRCm39) |
L227Q |
probably damaging |
Het |
Tet2 |
A |
T |
3: 133,173,145 (GRCm39) |
S1706T |
probably benign |
Het |
Ttc6 |
G |
A |
12: 57,720,002 (GRCm39) |
V858I |
probably benign |
Het |
Tut4 |
T |
A |
4: 108,412,730 (GRCm39) |
M1477K |
probably benign |
Het |
Vps13c |
C |
A |
9: 67,797,005 (GRCm39) |
A464E |
probably benign |
Het |
Zbtb17 |
T |
C |
4: 141,193,407 (GRCm39) |
|
probably null |
Het |
Zcwpw1 |
G |
A |
5: 137,815,783 (GRCm39) |
E429K |
probably benign |
Het |
|
Other mutations in Taar2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00229:Taar2
|
APN |
10 |
23,817,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL00807:Taar2
|
APN |
10 |
23,816,573 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01346:Taar2
|
APN |
10 |
23,816,997 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01433:Taar2
|
APN |
10 |
23,816,657 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01782:Taar2
|
APN |
10 |
23,817,042 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03106:Taar2
|
APN |
10 |
23,817,195 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03372:Taar2
|
APN |
10 |
23,817,069 (GRCm39) |
missense |
probably benign |
0.03 |
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0090:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0103:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0157:Taar2
|
UTSW |
10 |
23,817,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R0189:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0190:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0226:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0226:Taar2
|
UTSW |
10 |
23,816,961 (GRCm39) |
missense |
probably damaging |
1.00 |
R0265:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0267:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0349:Taar2
|
UTSW |
10 |
23,817,407 (GRCm39) |
missense |
probably benign |
0.01 |
R0349:Taar2
|
UTSW |
10 |
23,817,327 (GRCm39) |
missense |
possibly damaging |
0.79 |
R0426:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0556:Taar2
|
UTSW |
10 |
23,816,793 (GRCm39) |
missense |
probably damaging |
1.00 |
R1191:Taar2
|
UTSW |
10 |
23,816,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R2919:Taar2
|
UTSW |
10 |
23,817,454 (GRCm39) |
missense |
probably benign |
0.00 |
R4615:Taar2
|
UTSW |
10 |
23,817,263 (GRCm39) |
missense |
probably benign |
0.43 |
R4658:Taar2
|
UTSW |
10 |
23,817,401 (GRCm39) |
missense |
probably benign |
0.04 |
R4766:Taar2
|
UTSW |
10 |
23,816,669 (GRCm39) |
missense |
probably damaging |
0.98 |
R4872:Taar2
|
UTSW |
10 |
23,816,591 (GRCm39) |
missense |
probably benign |
0.02 |
R5205:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
0.42 |
R5271:Taar2
|
UTSW |
10 |
23,816,930 (GRCm39) |
missense |
probably damaging |
0.97 |
R5517:Taar2
|
UTSW |
10 |
23,816,627 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
R6325:Taar2
|
UTSW |
10 |
23,816,615 (GRCm39) |
missense |
probably benign |
0.05 |
R6398:Taar2
|
UTSW |
10 |
23,817,177 (GRCm39) |
missense |
probably benign |
0.00 |
R6762:Taar2
|
UTSW |
10 |
23,817,300 (GRCm39) |
missense |
probably damaging |
0.98 |
R7121:Taar2
|
UTSW |
10 |
23,816,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R7209:Taar2
|
UTSW |
10 |
23,816,597 (GRCm39) |
missense |
possibly damaging |
0.57 |
R7709:Taar2
|
UTSW |
10 |
23,816,621 (GRCm39) |
missense |
probably benign |
0.00 |
R8045:Taar2
|
UTSW |
10 |
23,817,386 (GRCm39) |
missense |
probably damaging |
1.00 |
R8223:Taar2
|
UTSW |
10 |
23,817,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R8743:Taar2
|
UTSW |
10 |
23,817,369 (GRCm39) |
missense |
probably damaging |
1.00 |
R9307:Taar2
|
UTSW |
10 |
23,817,237 (GRCm39) |
missense |
probably damaging |
1.00 |
R9350:Taar2
|
UTSW |
10 |
23,817,345 (GRCm39) |
missense |
probably damaging |
1.00 |
R9351:Taar2
|
UTSW |
10 |
23,816,900 (GRCm39) |
missense |
probably benign |
0.14 |
R9755:Taar2
|
UTSW |
10 |
23,817,038 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Taar2
|
UTSW |
10 |
23,817,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Predicted Primers |
PCR Primer
(F):5'- GCTCGCGTAATTGACAACTTGCC -3'
(R):5'- TCAGTCTCCTAAGCCCCTTGAAGC -3'
Sequencing Primer
(F):5'- CAGCCAAAACTTTAGGGATAGTG -3'
(R):5'- GCAAATTCATTCTTTGAGTGCCAG -3'
|
Posted On |
2013-07-30 |