Incidental Mutation 'R0101:Taar2'
ID |
33209 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Taar2
|
Ensembl Gene |
ENSMUSG00000059763 |
Gene Name |
trace amine-associated receptor 2 |
Synonyms |
Gpr58 |
MMRRC Submission |
038387-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0101 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
23814470-23817481 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 23817393 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Histidine
at position 311
(R311H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000078137
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079134]
|
AlphaFold |
Q5QD17 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000079134
AA Change: R311H
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000078137 Gene: ENSMUSG00000059763 AA Change: R311H
Domain | Start | End | E-Value | Type |
Pfam:7TM_GPCR_Srsx
|
42 |
318 |
2.4e-10 |
PFAM |
Pfam:7tm_1
|
48 |
303 |
2.9e-54 |
PFAM |
|
Meta Mutation Damage Score |
0.4819 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 94.0%
|
Validation Efficiency |
100% (50/50) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 47 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aatk |
C |
T |
11: 119,901,739 (GRCm39) |
D829N |
probably benign |
Het |
B3galnt1 |
A |
G |
3: 69,483,139 (GRCm39) |
Y41H |
probably benign |
Het |
Carmil3 |
A |
C |
14: 55,735,212 (GRCm39) |
|
probably benign |
Het |
Cdh17 |
A |
G |
4: 11,771,341 (GRCm39) |
Q41R |
probably benign |
Het |
Cep43 |
A |
T |
17: 8,388,374 (GRCm39) |
S76C |
possibly damaging |
Het |
Chrm2 |
G |
T |
6: 36,501,430 (GRCm39) |
C429F |
probably damaging |
Het |
Cplane1 |
T |
A |
15: 8,250,444 (GRCm39) |
C1844S |
probably benign |
Het |
Cyld |
T |
A |
8: 89,444,928 (GRCm39) |
|
probably null |
Het |
Cyp2d11 |
C |
A |
15: 82,274,395 (GRCm39) |
|
probably benign |
Het |
Dnah1 |
A |
G |
14: 31,005,856 (GRCm39) |
Y2308H |
probably damaging |
Het |
Dnajc27 |
T |
C |
12: 4,139,142 (GRCm39) |
V60A |
probably benign |
Het |
Dnmbp |
A |
G |
19: 43,862,599 (GRCm39) |
V850A |
possibly damaging |
Het |
Emcn |
A |
T |
3: 137,047,001 (GRCm39) |
M1L |
possibly damaging |
Het |
Epc1 |
A |
T |
18: 6,462,998 (GRCm39) |
|
probably benign |
Het |
Fbxo21 |
T |
C |
5: 118,133,521 (GRCm39) |
L310P |
probably damaging |
Het |
Filip1 |
A |
G |
9: 79,726,810 (GRCm39) |
I603T |
probably benign |
Het |
Fndc3b |
A |
G |
3: 27,512,957 (GRCm39) |
V723A |
probably damaging |
Het |
Gemin5 |
G |
A |
11: 58,036,322 (GRCm39) |
P674S |
probably damaging |
Het |
Gsk3a |
T |
C |
7: 24,928,328 (GRCm39) |
D471G |
probably benign |
Het |
Igbp1b |
G |
A |
6: 138,634,658 (GRCm39) |
P262L |
probably damaging |
Het |
Itga11 |
T |
C |
9: 62,651,768 (GRCm39) |
L300S |
probably damaging |
Het |
Itsn2 |
T |
C |
12: 4,683,058 (GRCm39) |
|
probably benign |
Het |
Lhcgr |
A |
G |
17: 89,072,598 (GRCm39) |
S150P |
probably damaging |
Het |
Man1a |
T |
C |
10: 53,951,120 (GRCm39) |
M1V |
probably null |
Het |
Mical2 |
C |
T |
7: 111,936,074 (GRCm39) |
R892C |
possibly damaging |
Het |
Mtus2 |
T |
C |
5: 148,019,845 (GRCm39) |
S747P |
probably damaging |
Het |
Mug1 |
A |
G |
6: 121,861,206 (GRCm39) |
K1276E |
possibly damaging |
Het |
Or1n1b |
A |
G |
2: 36,780,138 (GRCm39) |
S241P |
probably damaging |
Het |
Pfkfb4 |
C |
G |
9: 108,839,711 (GRCm39) |
P260R |
probably benign |
Het |
Prkca |
A |
T |
11: 107,948,626 (GRCm39) |
L121Q |
probably damaging |
Het |
Prpf40b |
T |
C |
15: 99,204,681 (GRCm39) |
|
probably benign |
Het |
Ripor2 |
T |
C |
13: 24,864,615 (GRCm39) |
M215T |
probably damaging |
Het |
Rpn1 |
A |
G |
6: 88,070,769 (GRCm39) |
D213G |
possibly damaging |
Het |
Rreb1 |
C |
A |
13: 38,115,518 (GRCm39) |
P959Q |
probably benign |
Het |
Sema5b |
T |
C |
16: 35,483,472 (GRCm39) |
|
probably benign |
Het |
Slc38a10 |
A |
G |
11: 120,041,903 (GRCm39) |
M1T |
probably null |
Het |
Slco1c1 |
G |
T |
6: 141,477,236 (GRCm39) |
L11F |
probably damaging |
Het |
Spef2 |
T |
C |
15: 9,713,194 (GRCm39) |
T393A |
probably damaging |
Het |
Srp54b |
A |
G |
12: 55,302,405 (GRCm39) |
|
probably benign |
Het |
St14 |
G |
T |
9: 31,008,403 (GRCm39) |
N512K |
probably benign |
Het |
Syce1l |
T |
A |
8: 114,382,061 (GRCm39) |
S237T |
probably benign |
Het |
Tamm41 |
A |
T |
6: 115,009,207 (GRCm39) |
Y129N |
probably damaging |
Het |
Tctn2 |
T |
C |
5: 124,753,357 (GRCm39) |
|
noncoding transcript |
Het |
Tpr |
T |
C |
1: 150,285,053 (GRCm39) |
|
probably benign |
Het |
Vsig10 |
T |
A |
5: 117,473,134 (GRCm39) |
|
probably null |
Het |
Zfp335 |
T |
C |
2: 164,741,910 (GRCm39) |
K635R |
probably damaging |
Het |
Zfp541 |
A |
G |
7: 15,811,968 (GRCm39) |
Y207C |
probably damaging |
Het |
|
Other mutations in Taar2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00229:Taar2
|
APN |
10 |
23,817,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL00807:Taar2
|
APN |
10 |
23,816,573 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01346:Taar2
|
APN |
10 |
23,816,997 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01433:Taar2
|
APN |
10 |
23,816,657 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01782:Taar2
|
APN |
10 |
23,817,042 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03106:Taar2
|
APN |
10 |
23,817,195 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03372:Taar2
|
APN |
10 |
23,817,069 (GRCm39) |
missense |
probably benign |
0.03 |
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0090:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0103:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0157:Taar2
|
UTSW |
10 |
23,817,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R0189:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0190:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0226:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0226:Taar2
|
UTSW |
10 |
23,816,961 (GRCm39) |
missense |
probably damaging |
1.00 |
R0265:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0267:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0349:Taar2
|
UTSW |
10 |
23,817,407 (GRCm39) |
missense |
probably benign |
0.01 |
R0349:Taar2
|
UTSW |
10 |
23,817,327 (GRCm39) |
missense |
possibly damaging |
0.79 |
R0426:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0556:Taar2
|
UTSW |
10 |
23,816,793 (GRCm39) |
missense |
probably damaging |
1.00 |
R0698:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R1191:Taar2
|
UTSW |
10 |
23,816,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R2919:Taar2
|
UTSW |
10 |
23,817,454 (GRCm39) |
missense |
probably benign |
0.00 |
R4615:Taar2
|
UTSW |
10 |
23,817,263 (GRCm39) |
missense |
probably benign |
0.43 |
R4658:Taar2
|
UTSW |
10 |
23,817,401 (GRCm39) |
missense |
probably benign |
0.04 |
R4766:Taar2
|
UTSW |
10 |
23,816,669 (GRCm39) |
missense |
probably damaging |
0.98 |
R4872:Taar2
|
UTSW |
10 |
23,816,591 (GRCm39) |
missense |
probably benign |
0.02 |
R5205:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
0.42 |
R5271:Taar2
|
UTSW |
10 |
23,816,930 (GRCm39) |
missense |
probably damaging |
0.97 |
R5517:Taar2
|
UTSW |
10 |
23,816,627 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
R6325:Taar2
|
UTSW |
10 |
23,816,615 (GRCm39) |
missense |
probably benign |
0.05 |
R6398:Taar2
|
UTSW |
10 |
23,817,177 (GRCm39) |
missense |
probably benign |
0.00 |
R6762:Taar2
|
UTSW |
10 |
23,817,300 (GRCm39) |
missense |
probably damaging |
0.98 |
R7121:Taar2
|
UTSW |
10 |
23,816,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R7209:Taar2
|
UTSW |
10 |
23,816,597 (GRCm39) |
missense |
possibly damaging |
0.57 |
R7709:Taar2
|
UTSW |
10 |
23,816,621 (GRCm39) |
missense |
probably benign |
0.00 |
R8045:Taar2
|
UTSW |
10 |
23,817,386 (GRCm39) |
missense |
probably damaging |
1.00 |
R8223:Taar2
|
UTSW |
10 |
23,817,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R8743:Taar2
|
UTSW |
10 |
23,817,369 (GRCm39) |
missense |
probably damaging |
1.00 |
R9307:Taar2
|
UTSW |
10 |
23,817,237 (GRCm39) |
missense |
probably damaging |
1.00 |
R9350:Taar2
|
UTSW |
10 |
23,817,345 (GRCm39) |
missense |
probably damaging |
1.00 |
R9351:Taar2
|
UTSW |
10 |
23,816,900 (GRCm39) |
missense |
probably benign |
0.14 |
R9755:Taar2
|
UTSW |
10 |
23,817,038 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Taar2
|
UTSW |
10 |
23,817,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Predicted Primers |
PCR Primer
(F):5'- GCTCGCGTAATTGACAACTTGCC -3'
(R):5'- TCAGTCTCCTAAGCCCCTTGAAGC -3'
Sequencing Primer
(F):5'- CAGCCAAAACTTTAGGGATAGTG -3'
(R):5'- GCAAATTCATTCTTTGAGTGCCAG -3'
|
Posted On |
2013-05-09 |