Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01310:Gpr19'

73655

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr19

Ensembl Gene

ENSMUSG00000032641

Gene Name

G protein-coupled receptor 19

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01310

Quality Score

Status

Chromosome

Chromosomal Location

134846055-134875157 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 134846705 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 289 (I289T)

Ref Sequence

ENSEMBL: ENSMUSP00000149995 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046255] [ENSMUST00000066107] [ENSMUST00000111932] [ENSMUST00000116515] [ENSMUST00000165392] [ENSMUST00000203409] [ENSMUST00000203762] [ENSMUST00000204880] [ENSMUST00000215088]

AlphaFold

Q61121

Predicted Effect

probably damaging
Transcript: ENSMUST00000046255
AA Change: I240T

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000047630
Gene: ENSMUSG00000032641
AA Change: I240T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	76	345	1.7e-12	PFAM
Pfam:7tm_1	82	330	1.8e-50	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000066107
AA Change: I326T

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000066287
Gene: ENSMUSG00000032641
AA Change: I326T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	76	345	1.7e-12	PFAM
Pfam:7tm_1	82	330	5.3e-45	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000111932
AA Change: I234T

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000107563
Gene: ENSMUSG00000032641
AA Change: I234T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000116515
AA Change: I234T

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000112214
Gene: ENSMUSG00000032641
AA Change: I234T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000165392
AA Change: I234T

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000127876
Gene: ENSMUSG00000032641
AA Change: I234T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203409

SMART Domains

Protein: ENSMUSP00000145128
Gene: ENSMUSG00000032641

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	132	9e-5	PFAM
Pfam:7tm_1	76	135	2.6e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203762

Predicted Effect

probably benign
Transcript: ENSMUST00000204880

SMART Domains

Protein: ENSMUSP00000144918
Gene: ENSMUSG00000032641

Domain	Start	End	E-Value	Type
transmembrane domain	59	76	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000215088
AA Change: I289T

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in increased anxiety-like behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930431F12Rik	A	T	5: 45,125,156 (GRCm39)		noncoding transcript	Het
Abca12	A	T	1: 71,323,315 (GRCm39)	I1589N	probably benign	Het
Abca8a	T	G	11: 109,950,801 (GRCm39)	D888A	probably benign	Het
Adam5	C	T	8: 25,232,150 (GRCm39)		probably benign	Het
Amer1	A	T	X: 94,470,716 (GRCm39)	N467K	probably benign	Het
Atp6v0a2	A	G	5: 124,783,968 (GRCm39)	D272G	probably damaging	Het
Cacna1b	A	T	2: 24,575,794 (GRCm39)	N751K	probably damaging	Het
Cfi	T	A	3: 129,652,080 (GRCm39)	N250K	probably damaging	Het
Cndp2	G	T	18: 84,689,002 (GRCm39)	P260Q	possibly damaging	Het
Cnnm3	A	G	1: 36,551,956 (GRCm39)	D322G	probably benign	Het
Crybg1	A	T	10: 43,851,054 (GRCm39)	S1606T	possibly damaging	Het
Crybg1	A	G	10: 43,879,596 (GRCm39)	S531P	probably damaging	Het
Espnl	A	T	1: 91,268,333 (GRCm39)	K320*	probably null	Het
Glt1d1	A	G	5: 127,709,384 (GRCm39)	T13A	possibly damaging	Het
Gpam	C	T	19: 55,066,764 (GRCm39)	A584T	possibly damaging	Het
Grm8	T	C	6: 27,363,800 (GRCm39)	I572V	probably damaging	Het
Gtpbp4	A	T	13: 9,027,308 (GRCm39)	N502K	probably benign	Het
Herpud2	T	C	9: 25,062,247 (GRCm39)	M6V	probably benign	Het
Igdcc3	T	C	9: 65,085,724 (GRCm39)	V263A	probably damaging	Het
Il33	G	A	19: 29,930,156 (GRCm39)	A65T	probably benign	Het
Itga9	T	A	9: 118,598,227 (GRCm39)	M1K	probably null	Het
Izumo3	T	C	4: 92,035,217 (GRCm39)		probably benign	Het
Kdr	G	A	5: 76,110,261 (GRCm39)	P909S	probably damaging	Het
Kirrel1	C	T	3: 86,997,182 (GRCm39)	E262K	probably benign	Het
Krt25	T	A	11: 99,208,996 (GRCm39)	Q278L	probably benign	Het
Lgi2	G	T	5: 52,711,807 (GRCm39)	P195Q	probably benign	Het
Lpcat3	T	C	6: 124,676,301 (GRCm39)	F120S	possibly damaging	Het
Nalcn	C	T	14: 123,554,661 (GRCm39)	R910Q	probably benign	Het
Nrxn1	A	G	17: 90,366,902 (GRCm39)		probably null	Het
Nuf2	A	T	1: 169,326,431 (GRCm39)	V440E	probably benign	Het
Or10ag60	T	A	2: 87,437,852 (GRCm39)	I40N	possibly damaging	Het
Or4f14	C	T	2: 111,742,652 (GRCm39)	V208M	probably benign	Het
Or51ah3	C	T	7: 103,210,008 (GRCm39)	S108F	probably benign	Het
Or6c205	T	C	10: 129,086,865 (GRCm39)	I154T	possibly damaging	Het
Pfpl	A	G	19: 12,405,974 (GRCm39)	D75G	probably damaging	Het
Pgm5	A	G	19: 24,812,130 (GRCm39)	V134A	possibly damaging	Het
Prkch	A	G	12: 73,805,787 (GRCm39)	I521V	possibly damaging	Het
Rps6kc1	T	A	1: 190,515,822 (GRCm39)	E968V	probably benign	Het
Slc25a30	T	C	14: 76,007,037 (GRCm39)	Y153C	probably damaging	Het
Smtnl2	T	A	11: 72,292,171 (GRCm39)		probably null	Het
Spmip4	C	A	6: 50,551,175 (GRCm39)	V425L	probably benign	Het
Tbc1d14	T	A	5: 36,700,544 (GRCm39)	K275*	probably null	Het
Tnc	T	C	4: 63,931,314 (GRCm39)	T799A	probably benign	Het
Trdn	A	T	10: 33,181,094 (GRCm39)		probably benign	Het
Ttn	T	C	2: 76,706,879 (GRCm39)		probably benign	Het
Uaca	T	C	9: 60,779,507 (GRCm39)	M1296T	probably benign	Het
Ubash3a	A	C	17: 31,434,116 (GRCm39)	I154L	probably benign	Het
Vmn2r4	T	A	3: 64,317,200 (GRCm39)		probably null	Het
Xpc	T	C	6: 91,467,089 (GRCm39)	K915E	probably benign	Het
Zfp318	T	C	17: 46,724,153 (GRCm39)	I2052T	possibly damaging	Het

Other mutations in Gpr19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01373:Gpr19	APN	6	134,847,284 (GRCm39)	missense	possibly damaging	0.81
IGL01988:Gpr19	APN	6	134,846,247 (GRCm39)	missense	probably damaging	1.00
R1530:Gpr19	UTSW	6	134,846,961 (GRCm39)	missense	probably damaging	0.97
R1548:Gpr19	UTSW	6	134,847,047 (GRCm39)	missense	possibly damaging	0.92
R1699:Gpr19	UTSW	6	134,847,192 (GRCm39)	missense	possibly damaging	0.93
R2131:Gpr19	UTSW	6	134,847,405 (GRCm39)	start codon destroyed	probably null	0.99
R5016:Gpr19	UTSW	6	134,846,880 (GRCm39)	nonsense	probably null
R6605:Gpr19	UTSW	6	134,847,398 (GRCm39)	missense	probably benign	0.02
R7080:Gpr19	UTSW	6	134,847,419 (GRCm39)	missense	probably damaging	0.99
R7746:Gpr19	UTSW	6	134,846,355 (GRCm39)	missense	probably damaging	1.00
R8014:Gpr19	UTSW	6	134,846,436 (GRCm39)	missense	probably damaging	1.00
R9176:Gpr19	UTSW	6	134,846,718 (GRCm39)	missense	probably damaging	0.99
R9408:Gpr19	UTSW	6	134,864,704 (GRCm39)	missense	unknown

Posted On

2013-10-07