Incidental Mutation 'IGL01475:Vmn1r6'
ID 88408
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r6
Ensembl Gene ENSMUSG00000115701
Gene Name vomeronasal 1 receptor 6
Synonyms V1rc20
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # IGL01475
Quality Score
Status
Chromosome 6
Chromosomal Location 56979340-56980251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 56979896 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 164 (F164S)
Ref Sequence ENSEMBL: ENSMUSP00000154199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079669] [ENSMUST00000226689] [ENSMUST00000227131] [ENSMUST00000227188] [ENSMUST00000227631] [ENSMUST00000227847] [ENSMUST00000228285]
AlphaFold Q8R2D4
Predicted Effect probably benign
Transcript: ENSMUST00000079669
AA Change: F186S

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: F186S

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.9e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226689
AA Change: F186S

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000227131
AA Change: F186S

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably damaging
Transcript: ENSMUST00000227188
AA Change: F164S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000227631
AA Change: F164S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000227847
AA Change: F186S

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000228285
AA Change: F186S

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik A T 14: 59,380,252 (GRCm39) N15K possibly damaging Het
Adam32 A T 8: 25,362,664 (GRCm39) I587K probably damaging Het
Adamtsl4 T C 3: 95,584,843 (GRCm39) S942G probably benign Het
Adamtsl5 A G 10: 80,180,750 (GRCm39) F104S probably damaging Het
Adgrf5 A G 17: 43,761,245 (GRCm39) D980G probably benign Het
Apba1 A T 19: 23,894,950 (GRCm39) D462V possibly damaging Het
Arhgef11 T C 3: 87,634,433 (GRCm39) probably benign Het
Cd74 T C 18: 60,943,393 (GRCm39) probably benign Het
Cdc16 T C 8: 13,831,542 (GRCm39) S592P probably benign Het
Cenpj A G 14: 56,802,502 (GRCm39) M21T possibly damaging Het
Col28a1 A G 6: 8,103,521 (GRCm39) L425S probably damaging Het
Dbt C T 3: 116,313,908 (GRCm39) T25I possibly damaging Het
Dguok C A 6: 83,467,552 (GRCm39) M98I possibly damaging Het
Dmxl1 T C 18: 50,004,781 (GRCm39) L943P probably damaging Het
Eloa G A 4: 135,738,231 (GRCm39) S243L probably benign Het
Enkur C A 2: 21,201,530 (GRCm39) A52S probably damaging Het
Ezh1 T C 11: 101,083,787 (GRCm39) E744G probably damaging Het
Fbxw11 T C 11: 32,672,101 (GRCm39) S190P possibly damaging Het
Foxb1 G A 9: 69,666,550 (GRCm39) probably benign Het
Gabra5 C T 7: 57,058,432 (GRCm39) G439S probably damaging Het
Gtf2h2 A T 13: 100,617,541 (GRCm39) V207D probably damaging Het
Hoatz A G 9: 51,011,358 (GRCm39) I93T probably benign Het
Krt76 A G 15: 101,796,948 (GRCm39) V317A probably benign Het
Lair1 C A 7: 4,012,683 (GRCm39) probably benign Het
Lrit2 T A 14: 36,791,051 (GRCm39) H243Q probably damaging Het
Mast3 C T 8: 71,232,174 (GRCm39) A1268T probably damaging Het
Matn2 G A 15: 34,316,671 (GRCm39) M4I possibly damaging Het
Mob1b T A 5: 88,897,502 (GRCm39) F137I probably damaging Het
Mreg T C 1: 72,203,325 (GRCm39) probably benign Het
Nom1 T C 5: 29,651,272 (GRCm39) V684A possibly damaging Het
Pate2 T A 9: 35,580,998 (GRCm39) L1Q probably null Het
Pla2r1 T C 2: 60,271,425 (GRCm39) probably benign Het
Plxna1 A G 6: 89,331,870 (GRCm39) F447L possibly damaging Het
Pno1 A T 11: 17,160,992 (GRCm39) I114N probably damaging Het
Ppp1r7 T G 1: 93,288,540 (GRCm39) probably benign Het
Pprc1 T A 19: 46,059,968 (GRCm39) Y1503N probably benign Het
Rab30 T C 7: 92,484,930 (GRCm39) V132A probably damaging Het
Slc15a4 T C 5: 127,679,024 (GRCm39) T439A probably benign Het
Slc29a3 A G 10: 60,559,596 (GRCm39) V186A possibly damaging Het
Stxbp5l G A 16: 37,165,454 (GRCm39) T88I possibly damaging Het
Tarbp1 A G 8: 127,160,701 (GRCm39) V1250A probably benign Het
Tcte2 A T 17: 13,937,824 (GRCm39) probably benign Het
Trp53bp1 A T 2: 121,100,800 (GRCm39) probably null Het
Trpc4 A T 3: 54,173,828 (GRCm39) L407F possibly damaging Het
Zfp579 C A 7: 4,997,743 (GRCm39) R56L probably benign Het
Other mutations in Vmn1r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Vmn1r6 APN 6 56,979,789 (GRCm39) missense probably damaging 1.00
IGL01011:Vmn1r6 APN 6 56,979,529 (GRCm39) missense probably benign 0.00
IGL01147:Vmn1r6 APN 6 56,979,626 (GRCm39) missense probably damaging 1.00
IGL01638:Vmn1r6 APN 6 56,980,177 (GRCm39) nonsense probably null
IGL01860:Vmn1r6 APN 6 56,979,674 (GRCm39) nonsense probably null
IGL01876:Vmn1r6 APN 6 56,979,446 (GRCm39) missense probably benign 0.12
IGL01988:Vmn1r6 APN 6 56,979,650 (GRCm39) missense probably damaging 0.99
R0531:Vmn1r6 UTSW 6 56,979,583 (GRCm39) missense probably benign 0.00
R1495:Vmn1r6 UTSW 6 56,980,058 (GRCm39) missense possibly damaging 0.58
R1733:Vmn1r6 UTSW 6 56,979,607 (GRCm39) missense probably damaging 1.00
R2037:Vmn1r6 UTSW 6 56,980,109 (GRCm39) missense probably damaging 1.00
R3625:Vmn1r6 UTSW 6 56,979,920 (GRCm39) missense probably damaging 0.96
R4353:Vmn1r6 UTSW 6 56,979,677 (GRCm39) missense possibly damaging 0.63
R4484:Vmn1r6 UTSW 6 56,980,174 (GRCm39) missense probably benign
R4854:Vmn1r6 UTSW 6 56,979,683 (GRCm39) missense probably benign 0.00
R5237:Vmn1r6 UTSW 6 56,980,179 (GRCm39) missense probably damaging 1.00
R5341:Vmn1r6 UTSW 6 56,979,789 (GRCm39) missense probably damaging 1.00
R5611:Vmn1r6 UTSW 6 56,979,362 (GRCm39) missense probably damaging 1.00
R6795:Vmn1r6 UTSW 6 56,979,422 (GRCm39) missense possibly damaging 0.85
R8423:Vmn1r6 UTSW 6 56,979,495 (GRCm39) missense probably benign 0.30
R9249:Vmn1r6 UTSW 6 56,979,760 (GRCm39) missense probably benign
R9582:Vmn1r6 UTSW 6 56,979,925 (GRCm39) missense probably benign
Posted On 2013-11-18