Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01734:Lrrc41'

105642

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc41

Ensembl Gene

ENSMUSG00000028703

Gene Name

leucine rich repeat containing 41

Synonyms

D730026A16Rik, MUF1, D630045E04Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.373) question?

Stock #

IGL01734

Quality Score

Status

Chromosome

Chromosomal Location

116075269-116097043 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 116093134 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000030471 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030471] [ENSMUST00000102704] [ENSMUST00000102705]

AlphaFold

Q8K1C9

Predicted Effect

probably null
Transcript: ENSMUST00000030471

SMART Domains

Protein: ENSMUSP00000030471
Gene: ENSMUSG00000028703

Domain	Start	End	E-Value	Type
low complexity region	30	45	N/A	INTRINSIC
low complexity region	280	291	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
low complexity region	352	382	N/A	INTRINSIC
low complexity region	417	429	N/A	INTRINSIC
SCOP:d1yrga_	449	742	4e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000102704

SMART Domains

Protein: ENSMUSP00000099765
Gene: ENSMUSG00000028702

Domain	Start	End	E-Value	Type
DEXDc	149	357	1.66e-41	SMART
Blast:DEXDc	391	427	5e-13	BLAST
low complexity region	441	456	N/A	INTRINSIC
HELICc	527	611	1.39e-20	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000102705

SMART Domains

Protein: ENSMUSP00000099766
Gene: ENSMUSG00000028702

Domain	Start	End	E-Value	Type
Pfam:Rad54_N	10	138	7.8e-9	PFAM
DEXDc	149	357	1.66e-41	SMART
Blast:DEXDc	391	427	5e-13	BLAST
low complexity region	441	456	N/A	INTRINSIC
HELICc	527	611	1.39e-20	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133799

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134983

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138952

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139147

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932442E05Rik	T	A	10: 118,861,466	W210R	possibly damaging	Het
Aknad1	T	C	3: 108,751,901	M77T	probably benign	Het
Aox2	A	T	1: 58,354,310	I1210F	possibly damaging	Het
Brd8	A	T	18: 34,614,805		probably benign	Het
Cdh23	T	C	10: 60,303,513	D3307G	probably benign	Het
Chsy1	T	C	7: 66,171,310	I431T	probably damaging	Het
Cobl	A	G	11: 12,254,980		probably benign	Het
Col28a1	T	C	6: 8,158,134	D308G	probably damaging	Het
Csmd3	A	G	15: 48,185,304	Y568H	probably damaging	Het
Dmrt3	T	C	19: 25,622,583	I264T	probably damaging	Het
Dusp22	G	T	13: 30,696,252	C52F	probably damaging	Het
Fbxw22	A	C	9: 109,383,925	M318R	probably damaging	Het
Ffar4	C	T	19: 38,113,847	T310M	probably damaging	Het
Fn1	A	G	1: 71,619,485	V1138A	probably damaging	Het
Glt6d1	T	A	2: 25,794,493	Y167F	probably benign	Het
Hydin	T	A	8: 110,490,789	Y1436*	probably null	Het
Il12a	G	A	3: 68,691,555	C2Y	possibly damaging	Het
Inpp5a	T	C	7: 139,454,090	Y38H	possibly damaging	Het
Jmy	A	C	13: 93,459,651	L490R	probably damaging	Het
Kif26a	T	A	12: 112,176,828	L1172H	probably benign	Het
Kmo	A	T	1: 175,655,102	M331L	probably benign	Het
Lonp1	G	A	17: 56,616,026	T627M	probably damaging	Het
Mast4	A	T	13: 102,737,615	S1556R	probably damaging	Het
Mmel1	A	G	4: 154,891,951	N490S	probably benign	Het
Mpped2	A	G	2: 106,783,813	D164G	probably damaging	Het
Nap1l1	A	G	10: 111,492,899	T230A	probably benign	Het
Nrap	C	A	19: 56,350,309	A913S	probably damaging	Het
Nudt16	G	T	9: 105,131,508	Q65K	probably benign	Het
Olfr1039	T	A	2: 86,131,668		probably benign	Het
Olfr199	T	G	16: 59,216,429	L61F	probably benign	Het
Olfr201	T	A	16: 59,268,850	K272N	probably benign	Het
Olfr382	C	A	11: 73,516,636	A188S	probably benign	Het
Olfr813	T	A	10: 129,856,802	C95S	probably benign	Het
Parp14	A	G	16: 35,858,600	F333L	probably benign	Het
Pi4ka	G	T	16: 17,297,260	Q1422K	probably benign	Het
Polr3c	T	C	3: 96,713,520	E494G	probably damaging	Het
Prss42	C	A	9: 110,798,343	P49Q	probably benign	Het
Ptpra	C	T	2: 130,544,077	T568I	probably damaging	Het
Ring1	T	C	17: 34,023,320	D71G	probably damaging	Het
Siae	T	A	9: 37,631,486	S193T	probably damaging	Het
Slf2	T	C	19: 44,973,267		probably null	Het
Spinkl	T	A	18: 44,174,572	K7N	possibly damaging	Het
Tbk1	G	A	10: 121,571,983	R82*	probably null	Het
Tcf12	T	C	9: 71,922,648		probably null	Het
Tcl1b5	G	A	12: 105,178,955	M59I	probably benign	Het
Thumpd3	C	A	6: 113,066,845	T407K	probably damaging	Het
Timm29	T	C	9: 21,593,735	V233A	probably damaging	Het
Tns3	A	G	11: 8,519,192		probably benign	Het
Ubash3b	T	C	9: 41,026,247		probably benign	Het
Ugdh	G	T	5: 65,422,688	T253K	probably benign	Het
Zfp143	T	A	7: 110,072,209		probably benign	Het
Zfp738	A	G	13: 67,683,444		probably benign	Het

Other mutations in Lrrc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01309:Lrrc41	APN	4	116096466	missense	probably damaging	0.97
IGL01358:Lrrc41	APN	4	116075587	missense	probably benign	0.16
IGL01986:Lrrc41	APN	4	116089322	missense	probably benign	0.27
IGL02159:Lrrc41	APN	4	116088486	missense	probably benign	0.03
IGL02892:Lrrc41	APN	4	116088835	missense	possibly damaging	0.68
IGL03135:Lrrc41	APN	4	116088531	missense	probably benign
R1478:Lrrc41	UTSW	4	116095208	nonsense	probably null
R1765:Lrrc41	UTSW	4	116089051	missense	possibly damaging	0.94
R2233:Lrrc41	UTSW	4	116096385	missense	possibly damaging	0.66
R4080:Lrrc41	UTSW	4	116080546	splice site	probably null
R4677:Lrrc41	UTSW	4	116095135	missense	probably benign
R4833:Lrrc41	UTSW	4	116093177	unclassified	probably benign
R4877:Lrrc41	UTSW	4	116079405	missense	probably damaging	0.99
R4926:Lrrc41	UTSW	4	116089324	missense	possibly damaging	0.46
R6459:Lrrc41	UTSW	4	116088780	missense	possibly damaging	0.95
R6817:Lrrc41	UTSW	4	116089305	missense	possibly damaging	0.66
R6834:Lrrc41	UTSW	4	116096529	missense	possibly damaging	0.46
R7479:Lrrc41	UTSW	4	116089041	missense	probably damaging	0.96
R7512:Lrrc41	UTSW	4	116092994	missense	possibly damaging	0.66
R7593:Lrrc41	UTSW	4	116092944	missense	possibly damaging	0.94
R8006:Lrrc41	UTSW	4	116094888	missense	possibly damaging	0.79
R8810:Lrrc41	UTSW	4	116075291	unclassified	probably benign
R9134:Lrrc41	UTSW	4	116088585	missense	possibly damaging	0.89
R9495:Lrrc41	UTSW	4	116075609	critical splice donor site	probably null

Posted On

2014-01-21