Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01777:Aadacl2'

154124

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Aadacl2

Ensembl Gene

ENSMUSG00000091376

Gene Name

arylacetamide deacetylase like 2

Synonyms

EG639634

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL01777

Quality Score

Status

Chromosome

Chromosomal Location

60006743-60025420 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 60024784 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 240 (V240A)

Ref Sequence

ENSEMBL: ENSMUSP00000129444 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169794]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169794
AA Change: V240A

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000129444
Gene: ENSMUSG00000091376
AA Change: V240A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:COesterase	91	219	2.7e-7	PFAM
Pfam:Abhydrolase_3	107	272	8.2e-38	PFAM
Pfam:Abhydrolase_3	270	375	3.2e-13	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194896

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195422

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aftph	A	T	11: 20,726,554	C352S	possibly damaging	Het
Cand2	T	C	6: 115,792,857	V876A	probably damaging	Het
Ccar1	T	C	10: 62,780,577	I125V	possibly damaging	Het
Celsr3	A	T	9: 108,835,942	M1858L	probably benign	Het
Csmd3	A	T	15: 47,698,198	N2134K	probably benign	Het
Dhx29	A	G	13: 112,930,872	I96V	probably benign	Het
Dst	A	G	1: 34,199,397	T3727A	probably benign	Het
Elavl4	T	A	4: 110,206,661		probably null	Het
Eno2	C	T	6: 124,766,637	G113D	probably damaging	Het
Esf1	A	C	2: 140,157,172		probably null	Het
Frmd4b	T	C	6: 97,295,944	D783G	probably benign	Het
Gm13023	T	G	4: 143,795,118	C435G	possibly damaging	Het
Grin2a	C	T	16: 9,644,130	V713I	probably benign	Het
Impa1	C	T	3: 10,322,948	G138D	probably damaging	Het
Kcnt2	A	G	1: 140,595,998	T1079A	probably benign	Het
Kmt2a	A	G	9: 44,849,005	S549P	probably damaging	Het
Magoh	C	A	4: 107,883,176	Q86K	probably benign	Het
Moxd1	C	A	10: 24,252,596	T182K	probably benign	Het
Olfr476	A	G	7: 107,967,502	Y35C	probably damaging	Het
Rab3b	A	T	4: 108,929,410	Q119L	probably damaging	Het
Snap47	T	A	11: 59,421,651		probably null	Het
Taar3	A	G	10: 23,950,005	R150G	probably benign	Het
Tas2r102	C	T	6: 132,762,852	T241I	probably damaging	Het
Tas2r114	C	T	6: 131,689,701	W121*	probably null	Het
Trak1	G	A	9: 121,431,560		probably null	Het
Ubn1	T	C	16: 5,072,149	V426A	possibly damaging	Het
Vmn1r40	T	C	6: 89,714,222	L7P	probably benign	Het
Vmn2r43	T	C	7: 8,255,273	I314V	probably damaging	Het
Vrtn	T	G	12: 84,648,922	S149A	probably benign	Het

Other mutations in Aadacl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01543:Aadacl2	APN	3	60024676	missense	probably benign
IGL01626:Aadacl2	APN	3	60019174	missense	probably damaging	1.00
IGL02189:Aadacl2	APN	3	60025188	missense	probably damaging	0.99
IGL03238:Aadacl2	APN	3	60024918	missense	probably benign	0.31
R0369:Aadacl2	UTSW	3	60024722	nonsense	probably null
R0540:Aadacl2	UTSW	3	60019206	missense	possibly damaging	0.50
R1440:Aadacl2	UTSW	3	60024892	missense	probably damaging	0.99
R1589:Aadacl2	UTSW	3	60010576	missense	probably benign	0.00
R1778:Aadacl2	UTSW	3	60017450	splice site	probably null
R1781:Aadacl2	UTSW	3	60024696	missense	probably damaging	1.00
R1812:Aadacl2	UTSW	3	60025077	missense	probably damaging	1.00
R2411:Aadacl2	UTSW	3	60017423	missense	possibly damaging	0.94
R4622:Aadacl2	UTSW	3	60007053	missense	probably damaging	1.00
R4698:Aadacl2	UTSW	3	60025039	missense	probably benign	0.00
R5326:Aadacl2	UTSW	3	60025063	missense	probably damaging	1.00
R5542:Aadacl2	UTSW	3	60025063	missense	probably damaging	1.00
R6314:Aadacl2	UTSW	3	60017403	missense	probably damaging	1.00
R6469:Aadacl2	UTSW	3	60024789	missense	probably benign	0.24
R6953:Aadacl2	UTSW	3	60024760	missense	possibly damaging	0.78
R7082:Aadacl2	UTSW	3	60024885	missense	probably damaging	1.00
R7206:Aadacl2	UTSW	3	60025241	missense	probably benign	0.17

Posted On

2014-02-04